rhodamine B methyl ester | 47742-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: rhodamine B methyl ester
• 英文别名: Xanthylium, 3,6-bis(diethylamino)-9-(2-(methoxycarbonyl)phenyl)-；[6-(diethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-diethylazanium
• CAS: 47742-71-2
• 化学式: C₂₉H₃₃N₂O₃
• 分子量: 457.593
• InChiKey: CKMFJWCEQQYCLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  rhodamine B methyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 N-(rhodamine B)-deoxylactam-5-amino-1-pentanol
  参考文献：
  名称：

  A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant

  摘要：

  N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.077

文献信息

• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。
• NOVEL TEMPERATURE-SENSITIVE FLUORESCENT COMPOUND AND APPLICATION THEREOF
  申请人：SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES

  公开号：US20160376247A1

  公开（公告）日：2016-12-29

  Provided is a compound represented by formula I, wherein R 9 is a C1-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, R 5 , R 6 , R 7 , and R 8 are alkyl groups or H, and R 1 , R 2 , R 3 , and R 4 are H or a lower hydrocarbyl group. Or, R 9 is a C2-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, and R 5 is connected to R 1 , R 6 is connected to R 2 , R 7 is connected to R 3 , R 8 is connected to R 4 to form six-membered rings. The present compound is temperature-sensitive and can enter into cells. An intracellular temperature distribution image having high spatial and temporal resolution can thus be obtained. The present compound can also perform distribution calibration on a temperature-sensitive fluorescent compound. Also provided is a method for measuring temperature distribution within a living cell, and a corresponding detection kit. The method satisfies the requirements of small size measurement and rapid measurement, thereby achieving high resolution in terms of space and time.

  提供的化合物由式I表示，其中R9是一个C1-C22烃基团，或者是一个C2-C3酯基取代的C1-C3烷基基团，R5、R6、R7和R8是烷基基团或氢，而R1、R2、R3和R4是氢或较低烃基基团。或者，R9是一个C2-C22烃基团，或者是一个C2-C3酯基取代的C1-C3烷基基团，而R5连接到R1，R6连接到R2，R7连接到R3，R8连接到R4形成六元环。这种化合物对温度敏感，可以进入细胞。因此，可以获得具有高空间和时间分辨率的细胞内温度分布图像。这种化合物还可以对温度敏感的荧光化合物进行分布校准。还提供了一种测量活细胞内温度分布的方法和相应的检测工具包。该方法满足了小尺寸测量和快速测量的要求，从而在空间和时间上实现高分辨率。
• [EN] POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY<br/>[FR] DÉRIVÉS DE POLY(ÉTHYLÈNE GLYCOL) POUR LA CHIMIE CLICK
  申请人：INTEZYNE TECHNOLOGIES INC

  公开号：WO2013106097A1

  公开（公告）日：2013-07-18

  The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

  本发明提供了双功能聚合物，其制备方法和中间体。这些化合物在各种应用中都很有用，包括对生物活性分子进行聚乙二醇化。本发明还提供了使用这些化合物及其组成物的方法。
• HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS
  申请人：Intezyne Technologies, Inc.

  公开号：US20150232616A1

  公开（公告）日：2015-08-20

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

  本发明涉及聚合物化学领域，更具体地涉及多嵌段共聚物及包含其的胶束。
• LYSOPHOSPHATIDIC ACID DETECTION
  申请人：Portland State University

  公开号：EP2970325B1

  公开（公告）日：2017-09-27