2-tert-butyl-1,3-oxathiolane | 17643-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧硫杂环戊烷
• 英文名称: 2-tert-butyl-1,3-oxathiolane
• 英文别名: 2-tert.-Butyl-1,3-oxathiolan；1,3-Oxathiolane, 2-(1,1-dimethylethyl)-
• CAS: 17643-69-5
• 化学式: C₇H₁₄OS
• 分子量: 146.254
• InChiKey: MWSYUUWTKSTCAI-UHFFFAOYSA-N

物化性质

• 沸点：
  197.0±33.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-tert-butyl-1,3-oxathiolane 在 氨 、 calcium 作用下， 生成 2-(2,2-dimethyl-propoxy)-ethanethiol
  参考文献：
  名称：

  Reductions with metal-ammonia combinations. II. Monothioacetals and monothioketals. Synthesis of alkoxymercaptans

  摘要：

  DOI：

  10.1021/jo00833a052

文献信息

• A ring expansion reaction of 1,3-oxathiolanes
  作者：Maria Ioannou、Michael J. Porter、Fabienne Saez

  DOI：10.1039/b110754b

  日期：2002.2.12

  1,3-Oxathiolanes are efficiently converted, via sulfur ylide intermediates, to 1,4-oxathianes by ring expansion with a silylated diazoacetate in the presence of a copper catalyst.

  在铜催化剂的作用下，1,3-氧硫杂环戊烷通过硫酰亚胺中间体与硅烷化重氮乙酸酯发生扩环反应，从而高效地转化为 1,4-氧硫杂环戊烷。
• Conversion of 1,3-oxathiolanes to 1,4-oxathianes using a silylated diazoester
  作者：Maria Ioannou、Michael J. Porter、Fabienne Saez

  DOI：10.1016/j.tet.2004.10.063

  日期：2005.1

  Treatment of substituted 1,3-oxathiolanes with ethyl (triethylsilyl)diazoacetate in the presence of a copper catalyst effects one-carbon ring expansion to the corresponding 3-triethylsilyl-1,4-oxathiane-3-carboxylates. Subsequent desilylation can be brought about by treatment with tetrabutyl ammonium fluoride. (C) 2004 Elsevier Ltd. All rights reserved.
• Topical Compositions Comprising Non-Proteogenic Amino Acids and Methods of Treating Skin
  申请人：Ptchelintsev Dmitri S.

  公开号：US20100261769A1

  公开（公告）日：2010-10-14

  Cosmetic compositions comprising non-natural, non-proteogenic amino acids and methods of using such compositions to impart antiaging benefits to the skin are disclosed. The non-natural, non-proteogenic amino acids are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging, and in particular, are enhancers of LOXL-1.
• Paxillin Stimulating Compositions and Cosmetic Uses Thereof
  申请人：ZHENG Qian

  公开号：US20110151029A1

  公开（公告）日：2011-06-23

  Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
• TYROSINASE INHIBITORS
  申请人：AVON PRODUCTS, INC.

  公开号：US20150164758A1

  公开（公告）日：2015-06-18

  The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.