[6]-gingerdiol | 39886-85-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [6]-gingerdiol
• 英文别名: gingerdiol；1-(4-Hydroxy-3-methoxyphenyl)decane-3,5-diol
• CAS: 39886-85-6
• 化学式: C₁₇H₂₈O₄
• 分子量: 296.407
• InChiKey: QYXKQNMJTHPKBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-羟基-1-(4-羟基-3-甲氧基苯基)-3-癸酮 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以96%的产率得到[6]-gingerdiol
  参考文献：
  名称：

  [EN] A PERSONAL CARE COMPOSITION
  [FR] COMPOSITION DE SOINS PERSONNELS

  摘要：

  本发明涉及一种个人护理组合物，主要用于预防或减少局部细胞的炎症。它可以以口腔护理、头发/头皮护理或皮肤护理组合物的形式提供，并包括姜二醇与维生素B3化合物的组合。

  公开号：

  WO2018041544A1

文献信息

• Biotransformation of pungent constituents from ginger (<i>Zingiber officinale</i> Roscoe) by <i>Colletotrichum gloeosporioides</i> yields oxidative <i>ortho</i>–<i>ortho</i> coupling products
  作者：Roberta Marques Dias de Ávila、Leonardo Toffano、João Batista Fernandes、Maria Fátima das Graças Fernandes da Silva、Lorena Ramos Freitas de Sousa、Paulo Cezar Vieira

  DOI：10.1080/10242422.2021.1878159

  日期：2022.3.4

  biphenol formation was proposed based on the presence of the intermediate 4-(2-hydroxyethyl)-2-methoxyphenol, commonly identified from [6]-gingerol and [6]-shogaol biodegradation. This intermediate likely originates from a Baeyer–Villiger reaction followed by hydrolysis. The C–C coupling of molecules could result in phenolic oxidative ortho–ortho coupling, suggesting that biphenol dimers are products of

  摘要 这项工作研究了病原真菌胶孢炭疽菌对生姜成分（姜油酮、[6]-姜烯酚、[6]-姜酚和甲基-[6]-姜酚）的生物转化。. 在有和没有氘标记的化合物的情况下进行实验。产物代谢物通过液相色谱-串联质谱联用和液相色谱固相萃取-核磁共振进行分析。提供给真菌的底物主要通过氧化反应（包括芳香族碳-碳偶联）进入代谢途径。姜油酮和[6]-姜酚生物转化产物包括双酚二聚体。基于中间体 4-(2-羟乙基)-2-甲氧基苯酚的存在，提出了一种用于形成双酚的生物降解途径，通常从 [6]-姜酚和 [6]-姜烯酚生物降解中鉴定出来。该中间体可能源自拜尔-维利格反应，然后是水解。分子的 C-C 偶联可导致酚类氧化邻 - 邻偶联，表明双酚二聚体是C. gloeosporioides漆酶催化的产物。
• A PERSONAL CARE COMPOSITION
  申请人：Unilever N.V.

  公开号：EP3506874A1

  公开（公告）日：2019-07-10
• PROCESS FOR PRODUCING AN ORAL CARE COMPOSITION COMPRISING GINGERDIOL
  申请人：UNILEVER GLOBAL IP LIMITED

  公开号：EP3952829B1

  公开（公告）日：2022-11-02
• ORAL CARE COMPOSITION COMPRISING GINGERDIOL AND PROCESS FOR PRODUCING THE COMPOSITION
  申请人：UNILEVER GLOBAL IP LIMITED

  公开号：EP3952829A1

  公开（公告）日：2022-02-16
• Compositions and Methods Comprising Zingiber Species
  申请人：Li Dan

  公开号：US20080160116A1

  公开（公告）日：2008-07-03

  An aspect of the present invention relates to compositions comprising a gingerol, for example, compositions comprising gingerol in an amount greater than about 2% by weight. In some aspects of the invention, the composition comprises 6-gingerol, 8-gingerol, 10-gingerol, 6-shagaol, or combinations thereof. Another aspect of the invention relates to a method for extracting a ginger species comprising, sequentially extracting a ginger species plant material to yield an essential oil fraction, a gingerol fraction, a phenolic fraction, and a polysaccharide fraction, wherein the essential oil and gingerol fractions are derived by extracting plant feedstock material by supercritical carbon dioxide extraction, the phenolic fraction is extracted from the plant feedstock material or from the remainder of the essential oil and gingerol extractions by hydroalcoholic extraction, and the polysaccharide fraction is derived by water extraction of the remainder of the phenolic extraction.