1-[2-(2-naphthyl)-2-(2,4-dichlorobenzyloxy)ethyl]imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[2-(2-naphthyl)-2-(2,4-dichlorobenzyloxy)ethyl]imidazole
• 英文别名: 1-[2-[(2,4-Dichlorophenyl)methoxy]-2-(2-naphthyl)ethyl]imidazole；1-[2-[(2,4-dichlorophenyl)methoxy]-2-naphthalen-2-ylethyl]imidazole
• 化学式: C₂₂H₁₈Cl₂N₂O
• 分子量: 397.304
• InChiKey: YQLDCMVKSMQCAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴代-2-乙酰基萘 在 sodium tetrahydroborate 、 sodium hydride 、 三乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 8.0h， 生成 1-[2-(2-naphthyl)-2-(2,4-dichlorobenzyloxy)ethyl]imidazole
  参考文献：
  名称：

  Aromatic ethers of 1-aryl 2-(1H-azolyl)ethanol: study of antifungal activity

  摘要：

  Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida. We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring. Activity is more strongly dependent on the substituent in the 2 position of the ethyl chain than on the aromatic group linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.

  DOI：

  10.1016/0223-5234(96)88315-2

文献信息

• Imidazole derivatives, pharmaceutical compositions containing them and their preparation
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0013786B1

  公开（公告）日：1982-10-06
• US4172141A
  申请人：——

  公开号：US4172141A

  公开（公告）日：1979-10-23
• Aromatic ethers of 1-aryl 2-(1H-azolyl)ethanol: study of antifungal activity
  作者：Y Wahbi、R Caujolle、C Tournaire、M Payard、M.D. Linas、J.P. Seguela

  DOI：10.1016/0223-5234(96)88315-2

  日期：1995.1

  Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida. We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring. Activity is more strongly dependent on the substituent in the 2 position of the ethyl chain than on the aromatic group linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.