| 169515-33-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 169515-33-7
• 化学式: C₅₃H₅₆N₅O₁₈P
• 分子量: 1082.02
• InChiKey: HRKWZONHHKXLSU-YENZBTJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  77.0
• 可旋转键数：
  22.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  298.14
• 氢给体数：
  3.0
• 氢受体数：
  20.0

反应信息

• 作为反应物：
  描述：

  在 1H-1,2,4-三唑 、 一水合肼 作用下， 以 吡啶 、 溶剂黄146 、 乙腈 为溶剂， 反应 8.05h， 生成
  参考文献：
  名称：

  Synthesis of 3′,5′-Dithymidylyl-α-hydroxyphosphonate Dimer Building Blocks for Oligonucleotide Synthesis—A New Pro-oliguncleotide

  摘要：

  The synthesis of the dimer building blocks 1 and 2 and their introduction into (T)(15)-oligonucleotides is described. The stability against 3'-exonuclease digestion (SVP) as well as the hybridization properties (T-m values) were examined.

  DOI：

  10.1080/07328319708006159
• 作为产物：
  描述：

  3'-O-levulinoylthymidine 在 三甲基乙酰氯 、 三乙胺 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 8.13h， 生成
  参考文献：
  名称：

  Synthesis of 3′,5′-Dithymidylyl-α-hydroxyphosphonate Dimer Building Blocks for Oligonucleotide Synthesis—A New Pro-oliguncleotide

  摘要：

  The synthesis of the dimer building blocks 1 and 2 and their introduction into (T)(15)-oligonucleotides is described. The stability against 3'-exonuclease digestion (SVP) as well as the hybridization properties (T-m values) were examined.

  DOI：

  10.1080/07328319708006159

文献信息

• Synthesis of Protected 3',5'-Di-2'-Deoxythymidine-(α-hydroxy-2-nitrobenzyl)-phosphonate Diesters as Dimer Building Blocks for Oligonucleotides
  作者：Chris Meier、Ralf Mauritz

  DOI：10.1080/15257779508012475

  日期：1995.5.1

  The synthesis of 3'-succinyl-CPG bound 3',5'-di-2'-deoxythymidyl-(alpha-hydroxy-2-nitrobenzyl)-phosphonate diester 1 and the 3'-phosphoamidite derivative 2 is descibed. The hydroxyl-groups of the backbone modification were protected with trialkylsilyl groups: TES and TBS. Compounds 1, 2 are suitable blocks for oligonucleotide synthesis.