1-(2-methoxyphenyl)-6,7-dimethoxyisochroman | 92774-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-(2-methoxyphenyl)-6,7-dimethoxyisochroman
• 英文别名: 6,7-dimethoxy-1-(2-methoxyphenyl)-3,4-dihydro-1H-isochromene
• CAS: 92774-36-2
• 化学式: C₁₈H₂₀O₄
• 分子量: 300.354
• InChiKey: BMECFSNBXFMNBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  423.4±45.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-methoxyphenyl)-6,7-dimethoxyisochroman 在 chromium(VI) oxide 、 硫酸 作用下， 以 水 、 丙酮 为溶剂， 反应 5.0h， 生成 1-(2-methoxyphenyl)-7,8-dimethoxy-3-methyl-3,5-dihydro-4H-2,3-benzodiazepin-4-one
  参考文献：
  名称：

  Gatta; Piazza; Del Giudice, Farmaco, Edizione Scientifica, 1985, vol. 40, # 12, p. 942 - 955

  摘要：

  DOI：
• 作为产物：
  描述：

  邻甲氧基苯甲醛 、 3,4-二甲氧基苯乙醇 在 silica-supported policresulen 作用下， 反应 5.0h， 以90%的产率得到1-(2-methoxyphenyl)-6,7-dimethoxyisochroman
  参考文献：
  名称：

  Silica-supported policresulen as a solid acid catalyst for organic reactions

  摘要：

  A new type of solid catalyst was prepared by coating a thin layer of policresulen, an inexpensive polymer prepared via condensation of 2-hydroxy-4-methylbenzenesulfonic acid and formaldehyde that has been used as commercially available drug, onto the surface of silica. The policresulen component is insoluble in many organic solvents and can be adsorbed on silica with the aid of hydrogen bonding. The obtained silica/policresulen composite showed remarkable catalytic activity for various organic reactions. In model reactions, the catalyst can be recycled several times without significant loss of activity. The salient features of using this acid catalyst in organic reactions include cost-effectiveness, simple and time-efficient preparation, and the convenience of controlling the acid loading on the solid. (C) 2015, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s1872-2067(15)60910-x

文献信息

• Gatta, Franco; Settimj, Guido, Gazzetta Chimica Italiana, 1984, vol. 114, # 3/4, p. 103 - 106
  作者：Gatta, Franco、Settimj, Guido

  DOI：——

  日期：——
• GATTA, F.;PIAZZA, D.;DEL, GIUDICE, M. R.;MASSOTTI, M., FARMACO. ED. SCI., 1985, 40, N 12, 942-955
  作者：GATTA, F.、PIAZZA, D.、DEL, GIUDICE, M. R.、MASSOTTI, M.

  DOI：——

  日期：——