[(2R,3S,5R)-3-acetyloxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methoxy-sulfidophosphanium | 151852-35-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: [(2R,3S,5R)-3-acetyloxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methoxy-sulfidophosphanium
• CAS: 151852-35-6
• 化学式: C₄₄H₄₉N₄O₁₄PS
• 分子量: 920.931
• InChiKey: INRSWFVTSDLXOY-DFMHVPIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  64
• 可旋转键数：
  18
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  200
• 氢给体数：
  2
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  [(2R,3S,5R)-3-acetyloxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methoxy-sulfidophosphanium 在 四氮唑 、 、 水 、 氢气 、 sodium hydride 作用下， 生成
  参考文献：
  名称：

  Helinski, Jan; Dabkowski, Wojciech; Michalski, Jan, Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 76, # 1-4, p. 135 - 138

  摘要：

  DOI：
• 作为产物：
  描述：

  [(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methoxyphosphanyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 作用下， 以 四氢呋喃 、 二异丙胺 为溶剂， 反应 2.0h， 以90%的产率得到[(2R,3S,5R)-3-acetyloxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methoxy-sulfidophosphanium
  参考文献：
  名称：

  O-Methyl-bis-O-(4-nitrophenyl)phosphite: a novel chemoselective O-phosphitylating reagent

  摘要：

  A novel chemoselective O-phosphitylating reagent containing two aryloxy leaving groups at a P(III) center is developed for selective formation of P(Ill) esters from amino alcohols without the need to protect the amino group. The reagent proved to be highly convenient for the synthesis of dinucleotides, P(III)-F structures, and cyclic P(III) nucleotides. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.102

文献信息

• Efficient oxygenation of thiophosphoryl and selenophosphoryl groups using trifluoroacetic anhydride
  作者：Jan Heliński、Zbisniew Skrzypczyński、Jacek Wasiak、Jan Michalski

  DOI：10.1016/s0040-4039(00)94505-2

  日期：1990.1

  Trifluoroacetic anhydride reacts with organophosphorus compounds containing thiophosphoryl and selenophosphoryl groups converting them in high yield to the corresponding oxygenated systems.

  三氟乙酸酐与含有硫代磷酰基和硒代磷酰基的有机磷化合物反应，将它们高产率地转化为相应的氧化体系。
• Misiura, Konrad; Szymanowicz, Daria; Stec, Wojciech J., Collection of Czechoslovak Chemical Communications, 1996, vol. 61, p. S101 - S106
  作者：Misiura, Konrad、Szymanowicz, Daria、Stec, Wojciech J.

  DOI：——

  日期：——