(5Z)-3-naphthalen-1-yl-5-(pyridin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one | 1336986-86-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (5Z)-3-naphthalen-1-yl-5-(pyridin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one
• CAS: 1336986-86-7
• 化学式: C₁₉H₁₃N₃OS
• 分子量: 331.398
• InChiKey: FAFABIJEEJNAGR-VBKFSLOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5Z)-3-naphthalen-1-yl-5-(pyridin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one 、 碘甲烷 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 以85%的产率得到(5Z)-2-methylsulfanyl-3-naphthalen-1-yl-5-(pyridin-2-ylmethylidene)imidazol-4-one
  参考文献：
  名称：

  Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies

  摘要：

  An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.118
• 作为产物：
  描述：

  吡啶-2-甲醛 、 3-(naphth-1-yl)-2-thioxoimidazolidin-4-one 在 potassium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以90%的产率得到(5Z)-3-naphthalen-1-yl-5-(pyridin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one
  参考文献：
  名称：

  Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies

  摘要：

  An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.118

文献信息

• TELOMERASE INHIBITORS AND A METHOD FOR THE PREPARATION THEREOF
  申请人：UCHREZHDENIE KHIMICHESKIJJ FAKUL'TET GOSUDARSTVENNOE UCHEBNO-NAUCHNOE

  公开号：US20130109861A1

  公开（公告）日：2013-05-02

  The invention relates to the field of organic and medicinal chemistry, and molecular biology, and concerns a method for the preparation of a new class of telomerase-inhibiting compounds, which can be utilized for studying telomerases and catalytic sub-units of telomerases, and reverse transcriptases, and foe studying and treating neoplastic and viral diseases. Telomerase-inhibiting coordination compounds of derivatives of imidazol-4-one are characterized by general formula

  本发明涉及有机化学、药物化学和分子生物学领域，涉及一种制备新型端粒酶抑制剂化合物的方法，可用于研究端粒酶和催化亚单位，以及反转录酶，用于研究和治疗肿瘤和病毒性疾病。咪唑-4-酮衍生物的端粒酶抑制配位化合物的一般式如下：
• Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies
  作者：Alexander G. Majouga、Anna V. Udina、Elena K. Beloglazkina、Dmitrii A. Skvortsov、Maria I. Zvereva、Olga A. Dontsova、Nikolay V. Zyk、Nikolay S. Zefirov

  DOI：10.1016/j.tetlet.2011.10.118

  日期：2012.1

  An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.