5-carboxyrhodamine 110 azide | 1416872-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-carboxyrhodamine 110 azide
• 英文别名: 3',6'-diazido-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid；3',6'-Diazido-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid；3',6'-diazido-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
• CAS: 1416872-33-7
• 化学式: C₂₁H₁₀N₆O₅
• 分子量: 426.348
• InChiKey: OFARTPNVDBBQQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  5-carboxyrhodamine 110 azide 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 bis(acetoxymethyl)
  参考文献：
  名称：

  FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES

  摘要：

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。

  公开号：

  US20120329085A1
• 作为产物：
  描述：

  偏苯三酸酐 在 硫酸 、 三氟乙酸 、 sodium nitrite 作用下， 以 水 、 乙腈 为溶剂， 反应 6.9h， 生成 5-carboxyrhodamine 110 azide
  参考文献：
  名称：

  FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES

  摘要：

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。

  公开号：

  US20120329085A1

文献信息

• A highly sensitive fluorescent probe for imaging hydrogen sulfide in living cells
  作者：Huatang Zhang、Ping Wang、Ganchao Chen、Hon-Yeung Cheung、Hongyan Sun

  DOI：10.1016/j.tetlet.2013.06.058

  日期：2013.9

  We report herein a fluorescent probe for the detection of hydrogen sulfide (H2S) with high sensitivity and selectivity. The probe is installed with double azide groups and displays high sensitivity to H2S (around 120-fold turn-on response). It reacts with H2S with high selectivity over other reactive sulfur, nitrogen, and oxygen species. The probe was also applied to detect H2S in living cells. (C) 2013 Elsevier Ltd. All rights reserved.
• Oligonucleotide-Templated Photoreduction Fluorogenic Probe Pairs and Their Use in Quantitative Detection of Target RNA Sequences
  申请人：Jan Biotech, Inc.

  公开号：US20220127670A1

  公开（公告）日：2022-04-28

  This application describes a fluorogenic nucleic acid kit or composition for quantitative detection of a target ribonucleic acid (RNA) sequence in a test sample comprising at least one pair of oligonucleotide probes comprising a photocatalyst probe and a profluorophore probe, wherein one of the photocatalyst probe and the profluorophore probe is complementary to and capable of specifically binding an upstream portion of the target RNA sequence, and the other probe is complementary to and capable of specifically binding to a downstream portion of the target RNA sequence, the photocatalyst probe comprises a first oligonucleotide covalently bound to a photocatalyst, the profluorophore probe comprises a second oligonucleotide covalently bound to a profluorophore, and the photocatalyst is activatable by exposure to light and a reducing agent to form a reduced, activated photocatalyst that, when both probes of the pair are hybridized to the target RNA sequence, is capable of photoreducing the profluorophore to form a detectable fluorophore. The application also describes methods for quantitative detection of target RNA.
• US9212189B2
  申请人：——

  公开号：US9212189B2

  公开（公告）日：2015-12-15
• FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES
  申请人：CHANG Christopher J.

  公开号：US20120329085A1

  公开（公告）日：2012-12-27

  The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。