N-(1-benzylpiperidin-4-yl)-5-chloro-1H-indazol-3-amine | 870766-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-benzylpiperidin-4-yl)-5-chloro-1H-indazol-3-amine
• CAS: 870766-01-1
• 化学式: C₁₉H₂₁ClN₄
• 分子量: 340.856
• InChiKey: FJMBKHDFFMUSOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基-5-氯-1H-吲唑 在 盐酸 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 12.0h， 生成 N-(1-benzylpiperidin-4-yl)-5-chloro-1H-indazol-3-amine
  参考文献：
  名称：

  Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists

  摘要：

  The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating hormone receptor-1 antagonists are reported, several of which demonstrated functional activity of less than 100 nM. Compounds 19 and 28, two of the more potent compounds identified in this study, were characterized by high exposure in the brain and demonstrated robust efficacy when dosed in diet-induced obese mice. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.08.049

文献信息

• Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists
  作者：Anil Vasudevan、Andrew J. Souers、Jennifer C. Freeman、Mary K. Verzal、Ju Gao、Mathew M. Mulhern、Derek Wodka、John K. Lynch、Kenneth M. Engstrom、Seble H. Wagaw、Sevan Brodjian、Brian Dayton、Doug H. Falls、Eugene Bush、Michael Brune、Robin D. Shapiro、Kennan C. Marsh、Lisa E. Hernandez、Christine A. Collins、Philip R. Kym

  DOI：10.1016/j.bmcl.2005.08.049

  日期：2005.12

  The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating hormone receptor-1 antagonists are reported, several of which demonstrated functional activity of less than 100 nM. Compounds 19 and 28, two of the more potent compounds identified in this study, were characterized by high exposure in the brain and demonstrated robust efficacy when dosed in diet-induced obese mice. (c) 2005 Published by Elsevier Ltd.