dibenzyl ethylphosphonate | 4537-62-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: dibenzyl ethylphosphonate
• 英文别名: Ethylphosphonsaeure-dibenzylester；[ethyl(phenylmethoxy)phosphoryl]oxymethylbenzene
• CAS: 4537-62-6
• 化学式: C₁₆H₁₉O₃P
• 分子量: 290.299
• InChiKey: WXXUSGKCYJWZTP-UHFFFAOYSA-N

物化性质

• 沸点：
  168 °C(Press: 0.6 Torr)
• 密度：
  1.148±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dibenzyl ethylphosphonate 在 三乙烯二胺 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以1.87 g的产率得到dibenzyl ethylphosphonic acid
  参考文献：
  名称：

  A concise synthesis of α-D-ribofuranosyl alkylphosphonates — Putative substrate intermediates for the carbon–phosphorous lyase system

  摘要：

  碳磷裂解酶是一种存在于多种细菌中的多酶系统，其特点是能够水解多种未活化的烷基膦酸盐。α-D-Ribofuranosyl 烷基膦酸盐是碳磷裂解酶途径产生的潜在代谢中间产物。关键词：碳磷裂解酶；phn操作子；phnN；膦酸盐；三氯乙酰亚氨酸糖基供体；α-D-核呋喃糖基乙基膦酸盐。

  DOI：

  10.1139/v06-038
• 作为产物：
  描述：

  乙基磷酸 、 苯甲醇 在 p-TsOH-Celite 作用下， 以87%的产率得到dibenzyl ethylphosphonate
  参考文献：
  名称：

  对甲苯磺酸-硅藻土作为在无溶剂条件下合成烷基膦酸酯的试剂

  摘要：

  在温和且无溶剂的条件下，烷基膦酸和醇在对甲苯磺酸-硅藻土表面的偶联反应以优异的产率得到相应的膦酸酯。该方法提供了一种有用的膦酸盐快速合成方法，可用于明确鉴定化学战剂。

  DOI：

  10.3184/030823407x218066

文献信息

• [EN] STRAD-BINDING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE LIAISON À STRAD ET LEURS UTILISATIONS
  申请人：UNIV CALIFORNIA

  公开号：WO2021155004A1

  公开（公告）日：2021-08-05

  Disclosed herein, inter alia, are compounds for binding STRAD pseudokinase and uses thereof.

  披露的内容包括，但不限于，用于结合STRAD假激酶的化合物及其用途。
• PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES
  申请人：Blumberg Laura Cook

  公开号：US20110319422A1

  公开（公告）日：2011-12-29

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  该发明提供了一种持续释放内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药的方法，通过向患者施用该发明的一种前药化合物的有效量，在向患者施用后，从前药中释放母药是持续释放的。适用于该发明方法的前药化合物是母药的不稳定结合物，通过羰基连接的前药基团进行衍生化。该发明的前药化合物可用于治疗任何需要内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药作为治疗的情况。
• ANTIVIRAL PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20110288053A1

  公开（公告）日：2011-11-24

  The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及具有抗病毒活性的磷取代化合物，含有这种化合物的组合物，以及包括给予这种化合物的治疗方法，还涉及用于制备这种化合物的过程和中间体。
• Polyester film, use thereof and metal laminated sheet made of said film, and metal can and metal lid made of the sheet
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP1186633A2

  公开（公告）日：2002-03-13

  A polyester film made from two kinds of polyester resins and having a specific DSC (and a specific glass transition point) is protrided, (i) which is superior in mechanical property, capable of thermocompresaion bonding with a metal sheet, despite a high degree of crystallization of the film, reduces quality change of plastic film laminated on the metal sheet even if faced with variation of conditions of thermocompression bonding with the metal sheet, and which is capable of thermocompression bonding even at a relatively low temperature, (ii) which is superior in formability, (iii) which is superior in flavoring property and impact resistance, and which obliterates occurrence of whitening or delamination of the film, or microcracks on the film, even if the film in the metal laminated sheet obtained by thermocompression bonding of the film on the metal sheet or on the surface of a metal can obtained by subjecting the metal laminated sheet to various form processings is crystallized, and (iv) which satisfies productivity at an industrial scale.

  突出了一种由两种聚酯树脂制成的具有特定 DSC（和特定玻璃化转变点）的聚酯薄膜，(i) 其机械性能优越，尽管薄膜的结晶程度较高，但仍能与金属板热压接合，即使与金属板热压接合的条件发生变化，也能减少与金属板层压的塑料薄膜的质量变化，而且即使在相对较低的温度下也能热压接合、(ii) 具有优异的成形性；(iii) 具有优异的调味性和抗冲击性，即使将薄膜热压粘合在金属板上或将金属层压板经过各种成形加工在金属表面获得的金属层压板中的薄膜结晶，也不会出现薄膜发白或分层或薄膜上出现微裂纹的情况；以及 (iv) 满足工业规模的生产率。
• Anti-blush and chemical resistant polyester film
  申请人：TORAY PLASTICS (AMERICA), INC.

  公开号：US11110688B2

  公开（公告）日：2021-09-07

  Embodiments herein relate to a polymer film comprising an anti-blushing composition in a blend comprising polyethylene terephthalate (PET) and polybutylene terephthalate (PBT); wherein the blend has an intrinsic viscosity above 0.75 and contains at least 50 wt. % of PBT; wherein the anti-blushing composition comprises a phosphorus containing compound but excludes certain phosphorus compounds; and wherein the anti-blushing composition is configured to prevent blushing in the polymer film laminated directly to a metal sheet and exposed to steam at a temperature of 260° F. for 90 minutes.

  本发明的实施例涉及一种聚合物薄膜，该薄膜在由聚对苯二甲酸乙二醇酯（PET）和聚对苯二甲酸丁二醇酯（PBT）组成的共混物中包含防脸红组合物；其中共混物的固有粘度高于0.75，并包含至少50 wt.其中，防起泡组合物包含含磷化合物，但不包括某些磷化合物；防起泡组合物用于防止直接与金属板层压并暴露于温度为 260°F 的蒸汽中 90 分钟的聚合物薄膜起泡。