1,3-diamino-2-propanol hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,3-diamino-2-propanol hydrochloride
• 英文别名: 1,3-Diaminopropan-2-ol;hydrochloride
• 化学式: C₃H₁₀N₂O*ClH
• 分子量: 126.586
• InChiKey: FNTWCJCVTYFVBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.31
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72.3
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-diamino-2-propanol hydrochloride 生成 N-(3-amino-2-hydroxypropyl)-2-[2-(2,6-dichloroanilino)phenyl]acetamide
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 1,3-diamino-2-propanol hydrochloride
  参考文献：
  名称：

  Mann, Journal of the Chemical Society, 1927, p. 2912

  摘要：

  DOI：

文献信息

• A Simple Conversion of Alcohols into Amines
  作者：Emmanuel Fabiano、Bernard T. Golding、Majid M. Sadeghi

  DOI：10.1055/s-1987-27887

  日期：——

  In a convenient one-pot sequence, treatment of alcohols and α-hydroxyesters with hydrazoic acid, di-isopropyl azodicarboxylate and an excess of triphenylphosphine in tetrahydrofuran, followed by addition of water or aqueous acid, yields amines or amino-acid esters in moderate to good overall yields.

  在一种便捷的一锅法反应序列中，通过将醇和α-羟基酯与叠氮酸、二异丙基偶氮二羧酸酯以及过量的三苯基膦在四氢呋喃中反应，随后加入水或酸溶液，可以得到中等至良好产率的胺或氨基酸酯。
• Acylated sugar derivatives, processes for their manufacture, and their
  申请人：Ciba-Geigy Corporation

  公开号：US04640911A1

  公开（公告）日：1987-02-03

  There are described sugar derivatives of the formula I ##STR1## that have immuno-stimulating action and that contain as inventive element at least one radical A.sup.1 or A.sup.2. These radicals A.sup.1 and A.sup.2, which may be constituents of the radicals R.sup.1, R.sup.2, R.sup.4, R.sup.6, R.sup.9, R.sup.10 or R.sup.12 according to formula I, are defined as follows: A.sup.1 represents lower alkanoyl that is substituted by aryl, heteroaryl or heteroarylthio and that may be additionally substituted by an ethylene radical which, with the above-mentioned aryl or heteroaryl substituent, forms a five-membered ring or represents ortho- or ortho/meta-substituted aroyl. A.sup.2 represents lower alkoxy substituted by aryl heteroaryl or heteroarylthio. Also described are processes for the manufacture of the compounds of the formula I and novel intermediates.

  描述了具有免疫刺激作用的I式糖衍生物##STR1##，其中包含至少一个基团A.sup.1或A.sup.2作为创新元素。根据式I，这些基团A.sup.1和A.sup.2可能是基团R.sup.1、R.sup.2、R.sup.4、R.sup.6、R.sup.9、R.sup.10或R.sup.12的组分，并定义如下：A.sup.1代表被芳基、杂芳基或杂芳硫取代的低碳酰基，可以附加地被乙烯基取代，该乙烯基与上述芳基或杂芳基取代物形成五元环，或者代表邻位或邻位/间位取代的芳酰基。A.sup.2代表被芳基、杂芳基或杂芳硫取代的低烷氧基。还描述了制备式I化合物和新中间体的方法。
• Thermodynamic Study on Dioxygen Binding of Diiron(II) and Dicobalt(II) Complexes Containing Various Dinucleating Ligands
  作者：Hideki Sugimoto、Toshihiko Nagayama、Sachihito Maruyama、Shuhei Fujinami、Yuichi Yasuda、Masatatsu Suzuki、Akira Uehara

  DOI：10.1246/bcsj.71.2267

  日期：1998.10

  A new dinucleating ligand containing a sterically bulky imidazolyl group, Ph-Htidp (N,N,N′,N′-tetrakis[(1-methyl-4,5-diphenyl-2-imidazolyl)methyl]-1,3-diamino-2-propanol), and its μ-alkoxo-diiron(II) complexes [Fe2(Ph-tidp)(RCO2)](ClO4)2, (RCO2 = C6H5CO2 (1), C6F5CO2 (2), CF3CO2 (3), and C2H5CO2 (4)), were synthesized. The structure of complex 1 was determined by X-ray crystallography. Complex 1 crystallizes

  一种含有空间庞大的咪唑基的新型双核配体 Ph-Htidp (N,N,N',N'-tetrakis[(1-methyl-4,5-diphenyl-2-imidazolyl)methyl]-1,3-diamino -2-丙醇）及其μ-烷氧-二铁（II）配合物 [Fe2(Ph-tidp)(RCO2)](ClO4)2, (RCO2 = C6H5CO2 (1), C6F5CO2 (2), CF3CO2 (3)和 C2H5CO2 (4)) 合成。配合物 1 的结构由 X 射线晶体学确定。配合物 1 在单斜空间群 P21/c 中结晶，a = 13.464(2), b = 19.223(4), c = 31.358(4) A, β = 92.84(2)°，Z = 4。具有Ph-tidp和μ-苯甲酸酯的μ-烷氧基的双桥接结构；两个铁中心具有扭曲的五坐标结构，带有 N3O2 供体组。所有配合物在低于 -30 °C
• Dinuclear Cobalt(II) Complexes Containing 1,3-(or 1,5-)Bis[bis(2-pyridylmethyl)amino]-2-propanolato (or -3-pentanolato): Preparation and Reaction with Molecular Oxygen
  作者：Masatatsu Suzuki、Toshiharu Sugisawa、Akira Uehara

  DOI：10.1246/bcsj.63.1115

  日期：1990.4

  Two dinuclear cobalt(II,II) complexes, [Co2(tpdp)(CH3COO)](ClO4)2·0.5H2O (1) and [Co2(tmdp)(CH3COO)](ClO4)2·H2O (2), were prepared, where Htpdp and Htmdp are 1,3-bis[bis(2-pyridylmethyl)amino]-2-propanol and 1,5-bis[bis(2-pyridylmethyl)amino]-3-pentanol respectively. Their electronic spectral and magnetic data revealed that 1 and 2 are five-coordinate in the high-spin state, in the same manner as

  两种双核钴 (II,II) 配合物 [Co2(tpdp)(CH3COO)](ClO4)2·0.5H2O (1) 和 [Co2(tmdp)(CH3COO)](ClO4)2·H2O (2) 分别是制备，其中Htpdp和Htmdp分别是1,3-双[双(2-吡啶基甲基)氨基]-2-丙醇和1,5-双[双(2-吡啶基甲基)氨基]-3-戊醇。他们的电子光谱和磁数据显示，1和2在高自旋状态下是五坐标，与[Co2(bpmp)(CH3COO)]2+(3) (Hbpmp=2,6-bis[双(2-吡啶基甲基)氨基甲基]-4-甲基苯酚)。配合物与分子氧反应在二氯甲烷和乙腈中形成μ-过氧配合物。配合物的氧亲和力以3>2>1的顺序降低。氧亲和力与（1）双核配体的供体能力之间的关系，
• Bergmann; Radt; Brand, Chemische Berichte, 1921, vol. 54, p. 1649
  作者：Bergmann、Radt、Brand

  DOI：——

  日期：——