4-nitrophenyl 4-difluoromethoxy-8-morpholinosulfonyldibenzo[b,d]furan-1-carboxylate | 887333-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-nitrophenyl 4-difluoromethoxy-8-morpholinosulfonyldibenzo[b,d]furan-1-carboxylate
• 英文别名: (4-Nitrophenyl) 4-(difluoromethoxy)-8-morpholin-4-ylsulfonyldibenzofuran-1-carboxylate
• CAS: 887333-74-6
• 化学式: C₂₄H₁₈F₂N₂O₉S
• 分子量: 548.478
• InChiKey: PYFBSKSHOGIEDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  150
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  4-氨基-3,5-二氯吡啶 、 4-nitrophenyl 4-difluoromethoxy-8-morpholinosulfonyldibenzo[b,d]furan-1-carboxylate 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3,5-dichloro-4-(4-difluoromethoxy-8-morpholinosulfonyldibenzo[b,d]furan-1-ylcarboxamido)pyridine
  参考文献：
  名称：

  WO2006/51390

  摘要：

  公开号：
• 作为产物：
  描述：

  4-difluoromethoxy-8-morpholinosulfonyldibenzo[b,d]furan-1-carboxylic acid 、 对硝基苯酚 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 4-nitrophenyl 4-difluoromethoxy-8-morpholinosulfonyldibenzo[b,d]furan-1-carboxylate
  参考文献：
  名称：

  WO2006/51390

  摘要：

  公开号：

文献信息

• [EN] 4-CYCLOALKYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES<br/>[FR] DERIVES DE 4-CYCLOALKYL-PYRIMIDINE-2-CARBONITRILE
  申请人：AKZO NOBEL NV

  公开号：WO2006040300A1

  公开（公告）日：2006-04-20

  The invention relates to 4-cycloalkyl-pyrimidine-2-carbonitrile derivatives having the general formula (I) wherein n is 0, 1, 2 or 3; R1 is H or (C1-6)alkyl; R2 is (C2-6)alkyl, optionally substituted with one or more halogens, OH, (C1-4)alkyloxy or NR3R4; R3 and R4 are independently H, (C1-4)alkyl, (C3-8)cycloalkyl, (C3-8)cycloalkyl(C1-4)alkyl, (C6-10)aryl, (C6-10)aryl(C1-4)alkyl, (C2-9)heteroaryl, (C2-9)heteroaryl(C1-4)alkyl or (C1-4)alkyl substituted with a 4-8 membered saturated heterocyclic ring comprising 1-3 heteroatoms selected from O, S and NR5; or R3 and R4 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, which ring optionally comprises NR5, and which ring is optionally substituted with (C6-10)aryl, (C6-10)aryloxy, (C6-10)aryl(C1-4)alkyloxy, (C2-9)heteroaryl, NR6,R7, CONR6R7 or NR6COR7; R5 is H, (C1-4)alkyl, (C6-10)aryl, (C6-10)aryl(C1-4)alkyl, (C2-5) heteroaryl or (C2-5)heteroaryl(C1-4)alkyl; R6 and R7 are independently H or (C1-4)alkyl; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said compounds as well as to the use thereof in the treatment of osteoporosis, atherosclerosis and related disorders.

  该发明涉及具有通式（I）的4-环烷基-嘧啶-2-腈衍生物，其中n为0、1、2或3；R1为H或（C1-6）烷基；R2为（C2-6）烷基，可选地取代一个或多个卤素、OH、（C1-4）烷氧基或NR3R4；R3和R4独立地为H、（C1-4）烷基、（C3-8）环烷基、（C3-8）环烷基（C1-4）烷基、（C6-10）芳基、（C6-10）芳基（C1-4）烷基、（C2-9）杂环芳基、（C2-9）杂环芳基（C1-4）烷基或取代有一个由O、S和NR5选择的1-3个杂原子的4-8成员饱和杂环的（C1-4）烷基；或R3和R4与它们连接的氮一起形成一个4-8成员饱和杂环，该环可选地包括NR5，并且该环可选地取代有（C6-10）芳基、（C6-10）芳氧基、（C6-10）芳基（C1-4）烷氧基、（C2-9）杂环芳基、NR6，R7、CONR6R7或NR6COR7；R5为H、（C1-4）烷基、（C6-10）芳基、（C6-10）芳基（C1-4）烷基、（C2-5）杂环芳基或（C2-5）杂环芳基（C1-4）烷基；R6和R7独立地为H或（C1-4）烷基；或其药学上可接受的盐。该发明还涉及包含所述化合物的药物组合物以及其在治疗骨质疏松症、动脉粥样硬化及相关疾病中的用途。
• New pyrazole derivatives as CRAC channel modulators
  申请人：Almirall, S.A.

  公开号：EP2848615A1

  公开（公告）日：2015-03-18

  The present invention relates to compounds of formula (I) which are inhibitors of CRAC channel activity. This invention also relates to pharmaceutical compositions containing them, process for their preparation and their use in therapy.

  本发明涉及一种具有式(I)的化合物，它们是CRAC通道活性的抑制剂。本发明还涉及含有这些化合物的药物组合物、它们的制备过程以及它们在治疗中的应用。
• [EN] HETEROCYCLIC SUBSTITUTED PYRAZOLONES<br/>[FR] PYRAZOLONES HETEROCYCLIQUES SUBSTITUES
  申请人：CEPHALON INC

  公开号：WO2001032653A1

  公开（公告）日：2001-05-10

  The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.

  本发明涉及新型杂环取代吡唑酮化合物，包括制备这些化合物的中间体和方法，以及包含这些化合物的药物组合物、诊断试剂盒、检测标准或试剂，并将其用作治疗的方法。
• Heterocyclic substituted pyrazolones
  申请人：Cephalon, Inc.

  公开号：US20030162775A1

  公开（公告）日：2003-08-28

  The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.

  本发明涉及新型杂环取代吡唑酮，包括含有这些化合物的药物组合物、诊断试剂盒、检测标准或试剂，并将其用作治疗方法。本发明还涉及制备这些新型化合物的中间体和方法。
• ARYL-AND ARYLAMINO-SUBSTITUTED HETEROCYCLES AS CORTICOTROPIN RELEASING HORMONE ANTAGONISTS
  申请人：Du Pont Pharmaceuticals Company

  公开号：EP0994860A1

  公开（公告）日：2000-04-26