N-[3-(2-benzothiazolyl)-4,5,6,7-tetrahydro-6-methylthieno[2,3-c]pyridin-2-yl]-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanamide | 1006595-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-[3-(2-benzothiazolyl)-4,5,6,7-tetrahydro-6-methylthieno[2,3-c]pyridin-2-yl]-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanamide
• 英文别名: N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-3-(1,3-dioxoisoindol-2-yl)propanamide
• CAS: 1006595-98-7
• 化学式: C₂₆H₂₂N₄O₃S₂
• 分子量: 502.618
• InChiKey: PZHJLHHLSJILRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,3-二氢-1,3-二氧代-2H-异吲哚-2-丙酰氯 、 3-(1,3-苯并噻唑-2-基)-6-甲基-4,5,6,7-四氢噻吩并[2,3-C]吡啶-2-胺 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 以60%的产率得到N-[3-(2-benzothiazolyl)-4,5,6,7-tetrahydro-6-methylthieno[2,3-c]pyridin-2-yl]-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanamide
  参考文献：
  名称：

  BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF

  摘要：

  提供了新型苯并噻唑基噻吡啶化合物以及含有苯并噻唑基噻吡啶化合物的药物组合物。这些苯并噻唑基噻吡啶化合物能够抑制血管内皮生长因子（VEGF）与肝素硫酸甘露聚糖（HS-GAGs）之间的相互作用，可用于预防或治疗炎症、自身免疫疾病和癌症等疾病和疾病。

  公开号：

  US20100298370A1

文献信息

• [EN] COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY<br/>[FR] COMPOSÉS POUR LA MODULATION DE L'ACTIVITÉ DE MYC
  申请人：SYROS PHARMACEUTICALS INC

  公开号：WO2016197078A1

  公开（公告）日：2016-12-08

  The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

  本发明提供了式（I）和式（II）的新化合物以及药学上可接受的盐、溶剂合物、水合物、互变异构体、立体异构体、同位素标记衍生物及其组合物。还提供了涉及这些化合物或组合物用于治疗或预防增生性疾病的方法和试剂盒，例如癌症（如乳腺癌、前列腺癌、淋巴瘤、肺癌、胰腺癌、卵巢癌、神经母细胞瘤或结肠直肠癌）、良性肿瘤、血管生成、炎症性疾病、纤维化（如多囊肾病）、自身炎症性疾病和自身免疫疾病的方法。
• Compounds for the modulation of myc activity
  申请人：Syros Pharmaceuticals, Inc.

  公开号：US10787444B2

  公开（公告）日：2020-09-29

  The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

  本发明提供了式(I)和式(II)的新型化合物及其药学上可接受的盐、溶液剂、水合物、同系物、立体异构体、同位素标记的衍生物及其组合物。还提供了涉及这些化合物或组合物的方法和试剂盒，用于治疗或预防增殖性疾病，如癌症（如乳腺癌、前列腺癌、淋巴瘤、肺癌、胰腺癌、卵巢癌、神经母细胞瘤或结肠直肠癌）、良性肿瘤、血管生成、炎症性疾病、纤维化（如多囊肾）、自身炎症性疾病和自身免疫性疾病。
• COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY
  申请人：Roberts Christopher

  公开号：US20180162851A1

  公开（公告）日：2018-06-14

  The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
• [EN] BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE THIÉNOPYRIDINE DE TYPE BENZOTHIAZOLYLE ET LEURS APPLICATIONS
  申请人：RIMONYX PHARMACEUTICALS LTD

  公开号：WO2008020438A2

  公开（公告）日：2008-02-21

  [EN] Novel benzothiazolyl thienopyridine compounds are provided and pharmaceutical compositions comprising benzothiazolyl thienopyridine compounds. The benzothiazolyl thienopyridine compounds are capable of inhibiting the interactions between vascular endothelial growth factor (VEGF) and heparan sulfate glycosaminoglycans (HS-GAGs), and are useful for prevention or treatment of diseases and disorders such as inflammation, autoimmune diseases and cancer.
  [FR] La présente invention concerne de nouvelles benzothiazolylthiénopyridines ainsi que les compositions pharmaceutiques comprenant lesdites benzothiazolylthiénopyridines. Les benzothiazolylthiénopyridines sont susceptibles d'inhiber les interactions entre le facteur de croissance endothéliale vasculaire (VEGF) et les glycosaminoglycanes de type héparane-sulfate (HS-GAG), et peuvent être employées dans le traitement prophylactique ou thérapeutique de maladies et de troubles tels que l'inflammation, les maladies auto-immunes et les cancers.
• BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF
  申请人：Gregor Paul

  公开号：US20100298370A1

  公开（公告）日：2010-11-25

  Novel benzothiazolyl thienopyridine compounds are provided and pharmaceutical compositions comprising benzothiazolyl thienopyridine compounds. The benzothiazolyl thienopyridine compounds are capable of inhibiting the interactions between vascular endothelial growth factor (VEGF) and heparan sulfate glycosaminoglycans (HS-GAGs), and are useful for prevention or treatment of diseases and disorders such as inflammation, autoimmune diseases and cancer.

  提供了新型苯并噻唑基噻吡啶化合物以及含有苯并噻唑基噻吡啶化合物的药物组合物。这些苯并噻唑基噻吡啶化合物能够抑制血管内皮生长因子（VEGF）与肝素硫酸甘露聚糖（HS-GAGs）之间的相互作用，可用于预防或治疗炎症、自身免疫疾病和癌症等疾病和疾病。