6-(N-phthalimidoylmethylthio)hexanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 6-(N-phthalimidoylmethylthio)hexanoic acid
• 英文别名: O-Phthalimide-C1-S-C5-acid；6-[(1,3-dioxoisoindol-2-yl)methylsulfanyl]hexanoic acid
• 化学式: C₁₅H₁₇NO₄S
• 分子量: 307.37
• InChiKey: LWRNKOWBHYCCAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-溴甲基邻苯二甲酰亚胺 、 6-巯基己酸 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以10%的产率得到6-(N-phthalimidoylmethylthio)hexanoic acid
  参考文献：
  名称：

  Development of Monoclonal ELISAs for Azinphos-methyl. 1. Hapten Synthesis and Antibody Production

  摘要：

  The development of monoclonal antibody-based enzyme-linked immunosorbent assays for azinphosmethyl is described. A panel of haptens was synthesized for immunoconjugate preparation, and a series of haptens for heterologous, coating or tracer, conjugates was also prepared. Hapten synthesis was based on a strategy in which only a fragment of the whole target molecule was present (fragmentary haptens). From immunized mice, a set of monoclonal antibodies was obtained and ELISA sensitivities were assayed in different formats. Affinities estimated as I-50 values in the low nanomolar range for azinphos-methyl and phosmet were observed for several monoclonal antibodies in the conjugate-coated format and in the antibody-coated format under nonoptimized assay conditions.

  DOI：

  10.1021/jf9808675

文献信息

• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.