1-(1,2,2,6,6-pentamethylpiperidin-4-yl)methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1,2,2,6,6-pentamethylpiperidin-4-yl)methanamine
• 英文别名: (1,2,2,6,6-Pentamethylpiperidin-4-yl)methanamine
• 化学式: C₁₁H₂₄N₂
• 分子量: 184.325
• InChiKey: LHOVWNIWUIWYIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1,2,2,6,6-pentamethylpiperidin-4-yl)methanamine 在 盐酸 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙酸乙酯 、 异丙醇 为溶剂， 反应 17.0h， 生成 5-fluoro-N²-[3-methoxy-5-(5-methyl-1H-tetrazol-1-yl)phenyl]-N⁴-[(1,2,2,6,6-pentamethylpiperidin-4-yl)methyl]pyrimidine-2,4-diamine
  参考文献：
  名称：

  Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug–drug interactions and P-gp liability

  摘要：

  Protein kinase C theta (PKC theta) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis. Here, a series of 2,4-diamino-5-fluoropyrimidine derivatives were prepared and evaluated for their inhibition of PKC theta. Of these compounds, 14f was found to exhibit potent PKC theta inhibitory activity and significantly weak CYP3A4 time-dependent inhibition (TDI) and P-glycoprotein (P-gp) liability. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.050
• 作为产物：
  描述：

  1,2,2,6,6-五甲基-4-哌啶酮 在 lithium aluminium tetrahydride 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 叔丁醇 为溶剂， 反应 5.0h， 生成 1-(1,2,2,6,6-pentamethylpiperidin-4-yl)methanamine
  参考文献：
  名称：

  Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug–drug interactions and P-gp liability

  摘要：

  Protein kinase C theta (PKC theta) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis. Here, a series of 2,4-diamino-5-fluoropyrimidine derivatives were prepared and evaluated for their inhibition of PKC theta. Of these compounds, 14f was found to exhibit potent PKC theta inhibitory activity and significantly weak CYP3A4 time-dependent inhibition (TDI) and P-glycoprotein (P-gp) liability. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.050

文献信息

• ADHESIVE COMPOSITION, LAMINATE, AND OPTICAL ARTICLE INCLUDING SAID LAMINATE
  申请人：Tokuyama Corporation

  公开号：EP3495441A1

  公开（公告）日：2019-06-12

  To provide an adhesive composition capable of firmly bonding polymer sheets together, comprising: (I) 100 parts by mass of an end-unreactive urethane urea resin; and (III) 4.0 to 20 parts by mass of a polyisocyanate compound having at least two isocyanate groups in the molecule, wherein the polyisocyanate compound (III) contains (IIIA) a polyisocyanate compound having an isocyanate group bonded to secondary carbon and (IIIB) a polyisocyanate compound having 4 to 30 carbon atoms in the molecule other than the component (IIIA), and the amount of the component (IIIB) is 10 to 500 parts by mass based on 100 parts by mass of the component (IIIA).

  提供一种能够将聚合物片材牢固粘合在一起的粘合剂组合物，该组合物包括 (I) 100 份（按重量计）端非反应型聚氨酯脲树脂；和 (III) 4.0至20份（质量份）分子中至少有两个异氰酸酯基团的多异氰酸酯化合物，其中多异氰酸酯化合物（III）包含（IIIA）分子中具有与仲碳键合的异氰酸酯基团的多异氰酸酯化合物和（IIIB）分子中除组分（IIIA）外具有4至30个碳原子的多异氰酸酯化合物，组分（IIIB）的用量以100份（质量份）组分（IIIA）为基准，为10至500份（质量份）。
• Laminate and optical article comprising the same
  申请人：TOKUYAMA CORPORATION

  公开号：US10690943B2

  公开（公告）日：2020-06-23

  To provide a laminate comprising a pair of polycarbonate optical sheet or film which are laminated together through a polarizing film layer and an adhesive layer of a photochromic composition comprising (I) a polyurethane urea resin and (II) a photochromic compound and having excellent photochromic properties, adhesion, heat resistance, perspiration resistance and excellent adhesion to a lens substrate.

  提供一种层压件，它由一对聚碳酸酯光学片材或薄膜组成，通过偏光膜层和由 (I) 聚氨酯脲醛树脂和 (II) 光致变色化合物组成的光致变色组合物粘合层层压在一起，具有优异的光致变色性能、粘合性、耐热性、耐汗渍性以及与镜片基板的优异粘合性。
• PHOTOCHROMIC COMPOSITION
  申请人：Tokuyama Corporation

  公开号：EP2602300B1

  公开（公告）日：2019-06-12
• LAMINATE AND OPTICAL ARTICLE USING SAID LAMINATE
  申请人：Tokuyama Corporation

  公开号：EP3399368B1

  公开（公告）日：2021-02-24
• Photochromic Composition
  申请人：Hiraren Toshimitsu

  公开号：US20130215488A1

  公开（公告）日：2013-08-22

  A photochromic composition, which can function as an adhesive layer for bonding optical sheets made from a polycarbonate resin, may include a polyurethane-urea resin (A) obtained by reacting a polyol compound (A1), a polyisocyante compound (A2) that has two or more isocyanato groups in the molecule, and an amino-containing compound (A3) that contains two or more isocyanato-reactive groups in the molecule, with at least one of the isocyanato-reactive groups being an amino group; and a photochromic compound (B).