5-methoxy-2-[(2-methylaminoethylimino)methyl]phenol | 1403954-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-methoxy-2-[(2-methylaminoethylimino)methyl]phenol
• 英文别名: 5-methoxy-2-[2-(methylamino)ethyliminomethyl]phenol
• CAS: 1403954-00-6
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: WTPFGPGHPAQMJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  53.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-methoxy-2-[(2-methylaminoethylimino)methyl]phenol 、 zinc(II) iodide 以 甲醇 为溶剂， 反应 1.0h， 以67%的产率得到
  参考文献：
  名称：

  Synthesis, Crystal Structures, and Urease Inhibitory Properties of Two Isostructural Dinuclear Zinc(II) Complexes With Schiff Base 5-Methoxy-2-[(2-methylaminoethylimino)methyl]phenol

  摘要：

  Two new isostructural dinuclear zinc(II) complexes with Schiff base 5-methoxy-2-[(2-methylaminoethylimino)methyl] phenol were prepared and characterized by elemental analyses, infrared spectroscopy, and single-crystal X-ray diffraction. Both complexes are phenolate O-bridged dinuclear zinc(II) compounds with crystallographic twofold rotation axis symmetry. The Schiff base acts as a tridentate chelating ligand. The Zn atom is five-coordinated in a square pyramidal geometry. The preliminary urease inhibitory activity of both complexes was investigated.

  DOI：

  10.1080/15533174.2012.680151
• 作为产物：
  描述：

  2-羟基-4-甲氧基苯甲醛 、 N-甲基乙二胺 以 甲醇 为溶剂， 生成 5-methoxy-2-[(2-methylaminoethylimino)methyl]phenol
  参考文献：
  名称：

  HYDROGEN-BOND INDUCED SYNTHESIS, CHARACTERIZATION, AND CRYSTAL STRUCTURES OF END-TO-END AZIDO-BRIDGED POLYMERIC COPPER(II) COMPLEXES DERIVED FROM TRIDENTATE SCHIFF BASES

  摘要：

  DOI：

  10.4067/s0717-97072013000200030

文献信息

• Synthesis and crystal structures of dimeric schiff base oxovanadium(V) complexes with antimicrobial activity
  作者：G. X. He、L. W. Xue、G. Q. Zhao

  DOI：10.1134/s1070328413100023

  日期：2013.10

  Two new dimeric oxovanadium(V) complexes, [VO2L1](2) center dot 2H(2)O (I) and [VO2L2](2) (II), where L-1 and L-2 are the monoanionic form of 5-methoxy-2-[(2-methylaminoethylimino)methyl]phenol (HL1) and 5-diethylamino-2-[(2-methylaminoethylimino)methyl]phenol (HL2), respectively, have been synthesized and characterized by elemental analysis, FT-IR spectra, and single crystal X-ray determination. The crystal of I is monoclinic: space group P2(1), a = 6.858(2), b = 16.630(3), c = 12.306(2) , beta = 103.985(2)A degrees, V = 1361.9(5) (3), Z = 2. The crystal of II is triclinic: space group , a = 7.378(2), b = 8.838(2), c = 13.312(3) , alpha = 102.576(2)A degrees, beta = 92.044(2)A degrees, gamma = 113.017(2)A degrees, V = 772.7(3) (3), Z = 2. The V...V distances are 3.140(1) in I and 3.254(1) in II. The V atoms in the complexes are in octahedral coordination. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was studied.