1-tetralone-2-carbothionic acid p-chloro-anilide | 125341-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-tetralone-2-carbothionic acid p-chloro-anilide
• 英文别名: N-(4-chlorophenyl)-1-oxo-3,4-dihydro-2H-naphthalene-2-carbothioamide
• CAS: 125341-78-8
• 化学式: C₁₇H₁₄ClNOS
• 分子量: 315.823
• InChiKey: OBZFZPLWNBJNNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-tetralone-2-carbothionic acid p-chloro-anilide 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 4.5h， 生成 (2S)-2-(4-chlorophenyl)-2-[(1R,9R)-11-(4-chlorophenyl)-8-oxo-10-sulfanylidene-11-azatricyclo[7.2.1.02,7]dodeca-2,4,6-trien-9-yl]acetonitrile
  参考文献：
  名称：

  通过多官能化的螺环化噻吩的立体选择性合成桥接的氮杂环庚烷衍生物。肟酯的新型重排。

  摘要：

  DOI：

  10.1021/jo010349k
• 作为产物：
  描述：

  4-氯异硫氰酸苯酯 、 3,4-二氢-1(2H)-萘酮 在 sodium hydride 作用下， 生成 1-tetralone-2-carbothionic acid p-chloro-anilide
  参考文献：
  名称：

  Bogdanowicz-Szwed, Krystyna; Kozicka, Michalina; Lipowska, Malgorzata, Journal fur praktische Chemie (Leipzig 1954), 1989, vol. 331, # 2, p. 231 - 242

  摘要：

  DOI：

文献信息

• Enantioselective Synthesis of Ring-Fused Spiroannulated 1,2,3-Thiadiazole Derivatives
  作者：Xue-Mei Zeng、Jian-Wu Xie

  DOI：10.1021/acs.joc.6b00127

  日期：2016.5.6

  An organocatalytic enantioselective domino α-amination/oxidative coupling/cyclization of thioamides to azodicarboxylates catalyzed by an easily available organic catalyst has been developed. The key step, oxidative coupling, is smoothly fulfilled in air. Optically active spiroannulated 1,2,3-thiadiazole derivatives are obtained with high yields and enantioselectivities for the first time.

  已经开发了由容易获得的有机催化剂催化的硫代酰胺的有机催化对映选择性多米诺骨牌α-氨基化/氧化偶联/环化成偶氮二羧酸酯。氧化偶联的关键步骤是在空气中平稳完成。首次以高收率和对映选择性获得旋光的螺环化的1,2,3-噻二唑衍生物。
• Simultaneous diversity-oriented synthesis of benzothiazoles and related diverse analogues by iodine-catalyzed intramolecular cyclization from identical substrates
  作者：Meng Cui、Xue-Lin Wang、Mengzhou Wang、Jian-Wu Xie

  DOI：10.1071/ch23144

  日期：——

  A facile oxidative cyclization of β-ketothioamides for the simultaneous formation of a compound library similar to natural product benzothiazole derivatives has been developed. The oxidative cyclization of β-ketothioamides resulted in the simultaneous formation of four classes of previously unknown benzothiazole derivatives. This chemistry’s versatility adds a valuable component to the methodology

  开发了一种易于氧化环化的β-酮硫酰胺，用于同时形成类似于天然产物苯并噻唑衍生物的化合物库。β-酮硫酰胺的氧化环化导致同时形成四类以前未知的苯并噻唑衍生物。这种化学的多功能性为获得苯并噻唑衍生物的方法增添了宝贵的组成部分。
• Participation of β-Ketothioamides in N-Heterocyclic Carbene-Catalyzed [3 + 3] Spiroannulation: Asymmetric Synthesis of Functionalized Spiro-piperidinone Derivatives
  作者：Hong Lu、Chang-Yin Tan、Huan-Xin Zhang、Jia-Lu Zhang、Jin-Yu Liu、Hong-Yu Li、Peng-Fei Xu

  DOI：10.1021/acs.joc.8b02520

  日期：2018.12.21

  An N-heterocyclic carbene-catalyzed asymmetric [3 + 3] spiroannulation of beta-ketothioamide was successfully developed. beta-Ketothioamides exhibit an unusual reactivity to undergo a previously challenging lactamization reaction, and the desired spiro-piperidinone derivatives containing two vicinal stereogenic centers were synthesized in good to high yields with high stereoselectivities, whose structure can be converted to the corresponding imide and delta-lactam derivatives smoothly.
• N-Substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides with anti-inflammatory and analgesic activities
  作者：Silvia Schenone、Olga Bruno、Angelo Ranise、Francesco Bondavalli、Giuseppe Falcone、Walter Filippelli、Barbara Rivaldi

  DOI：10.1016/s0014-827x(00)00055-0

  日期：2000.5

  A series of substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides was synthesized and tested in comparison with former analogues. The title compounds showed only weak antiarrhythmic properties but good anti-inflammatory and antinociceptive activity, particularly evident in the morpholino derivative. (C) 2000 Published by Elsevier Science S.A. All rights reserved.
• Synthesis of functionalized pyridines and thiophenes by Michael addition of some ?-keto carbothioic acid anilides to electrophilic olefins
  作者：Krystyna Bogdanowicz-Szwed、Ireneusz Nowak、Marcin Tyrka

  DOI：10.1002/prac.19953370117

  日期：——