guaiacyl glycerol | 1208-42-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: guaiacyl glycerol
• 英文别名: guaiacylglycerol；guaicylglycerol；α-Guajacylglycerin；1-(4-hydroxy-3-methoxyphenyl)propane-1,2,3-triol
• CAS: 1208-42-0
• 化学式: C₁₀H₁₄O₅
• 分子量: 214.218
• InChiKey: LSKFUSLVUZISST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  guaiacyl glycerol 在 水 、 sodium hydrogensulfite 作用下， 生成 2,3-dihydroxy-1-(4-hydroxy-3-methoxy-phenyl)-propane-1-sulfonic acid ; barium salt
  参考文献：
  名称：

  Stumpf; Rumpf, Justus Liebigs Annalen der Chemie, 1956, vol. 599, p. 51,56

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3- trihydroxypropyl)-2-methoxy]-phenoxy-1, 3-propandiol 生成 guaiacyl glycerol
  参考文献：
  名称：

  Nimz,H., Chemische Berichte, 1967, vol. 100, p. 181 - 186

  摘要：

  DOI：

文献信息

• ANTIHYPERTENSIVE POLYOL COMPOUND AND DERIVATIVE THEREOF
  申请人：East China University of Science and Technology

  公开号：EP3906969A1

  公开（公告）日：2021-11-10

  The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

  本发明提供了一种由式I代表的化合物，或其药用可接受的盐或酯，前药，光学异构体，立体异构体或其溶剂合物。本发明提供的化合物可用于制备用于预防或治疗高血压或与高血压相关疾病，或肺动脉高压或与肺动脉高压相关疾病的药物。本发明提供的化合物与现有用于治疗高血压和肺动脉高压的药物具有不同的机制，从而为开发用于治疗高血压和肺动脉高压的药物奠定了新的物质基础。
• New CuCl2-induced glucoside esters and other constituents from Portucala oleracea
  作者：Bin Wu、Liyan Yu、Xiaodan Wu、Jianbo Chen

  DOI：10.1016/j.carres.2012.01.012

  日期：2012.4

  Two new glucoside esters 1 and 2 were produced as stress metabolites in the fresh leaves of Portulaca oleracea, in response to abiotic stress elicitation by CuCl(2). A new sugar ester (3) and two known compounds (4 and 5) were also isolated. Their structures were established by spectroscopic means. The antioxidative activities of stress metabolites and the related isolates were evaluated by DPPH assay

  响应CuCl（2）引起的非生物胁迫，在马齿Port的新鲜叶片中产生了两种新的葡萄糖苷酯1和2作为胁迫代谢物。还分离出一种新的糖酯（3）和两种已知的化合物（4和5）。它们的结构是通过光谱学方法确定的。通过DPPH分析评估应激代谢产物和相关分离物的抗氧化活性。结果表明，新的应力驱动的单葡聚糖和单萜具有葡萄糖桥的加合物显示出比其他化合物强得多的抗氧化活性。
• The constituents of Eucommia ulmoides Oliv. III. Isolation and structure of a new lignan glycoside.
  作者：TAKESHI DEYAMA、TAKAKO IKAWA、SHIZUKA KITAGAWA、SANSEI NISHIBE

  DOI：10.1248/cpb.34.523

  日期：——

  A new lignan glycoside was isolated from the bark of Eucommia ulmoides OLIV. (Eucommiaceae) and its structure was established as (+)-1-hydroxypinoresinol 4"-O-β-D-glucopyranoside (1) on the basis of chemical evidence and spectroscopic studies. An isomer of 1, (+)-1-hydroxypinoresinol 4'-O-β-D-glucopyranoside (2), was also isolated, together with (±)-erythro-, and (±)-threo-guaiacylglycerol (3 and 4), (+)-cyclo-olivil (5) and (-)-olivil (6).

  从杜仲（Eucommia ulmoides OLIV.(根据化学证据和光谱研究，确定其结构为 (+)-1-hydroxypinoresinol 4"-O-β-D-glucopyranoside (1)。此外，还分离出了 1 的异构体 (+)-1-hydroxypinoresinol 4'-O-β-D-glucopyranoside (2)，以及 (±)-erythro- 和 (±)-threo-guaiacylglycerol (3 和 4)、(+)-cyclo-olivil (5) 和 (-)-olivil (6)。
• In vitro methods for processing lignin and other aromatic compounds
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US10829745B2

  公开（公告）日：2020-11-10

  Enzymes for depolymerizing lignin. The enzymes include dehydrogenases, β-etherases, and glutathione lyases. The dehydrogenases can comprise one or more or LigD, LigO, LigN, and LigL. The β-etherases can comprise one or more of LigE, LigF, LigP, and BaeA. The glutathione lyases can comprise any one or more of LigG and a number of non-stereospecific, optionally recombinant glutathione lyases derived from Sphingobium sp. SYK-6, Novosphingobium aromaticivorans, Escherichia coli, Streptococcus sanguinis, Phanerochaete chrysosporium, and other microorganisms. The enzymes can be combined in compositions and/or used in methods of processing lignin or other aromatic compounds in vitro.

  用于解聚木质素的酶。这些酶包括脱氢酶、β-乙醚酶和谷胱甘肽裂解酶。脱氢酶可包括一种或多种 LigD、LigO、LigN 和 LigL。β-乙醚酶可包括 LigE、LigF、LigP 和 BaeA 中的一种或多种。谷胱甘肽裂解酶可包括 LigG 和一些非立体特异性的、可选择重组的谷胱甘肽裂解酶中的一种或多种，这些谷胱甘肽裂解酶来源于 Sphingobium sp. SYK-6、Novosphingobium aromaticivorans、大肠杆菌、血链球菌、Phanerochaete chrysosporium 和其他微生物。这些酶可以组合成组合物和/或用于体外处理木质素或其他芳香族化合物的方法中。
• [EN] ANTIHYPERTENSIVE POLYOL COMPOUND AND DERIVATIVE THEREOF<br/>[FR] COMPOSÉ POLYOL ANTIHYPERTENSEUR ET DÉRIVÉ DE CELUI-CI<br/>[ZH] 抗高血压的多元醇化合物及其衍生物
  申请人：UNIV EAST CHINA SCIENCE & TECH

  公开号：WO2020249117A1

  公开（公告）日：2020-12-17

  本发明提供式I所示化合物、或其药学上可接受的盐或酯、前药、光学异构体、立体异构体或溶剂合物。本发明的化合物能够用于制备预防或治疗高血压或高血压相关疾病或肺动脉高压或肺动脉高压相关疾病的药物。本发明的化合物与现有的治疗高血压和肺动脉高压的药物具备不同的机理，从而为开发高血压和肺动脉高压治疗药物奠定了全新的物质基础。