tigogenin-3-O-α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-xylopyranoside

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: tigogenin-3-O-α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-xylopyranoside
• 英文别名: tigogenin-3-O-α-L-rhamnopyranosyl-(1-4)-β-D-glucopyranosyl-(1-3)-β-D-xylopyranosyl-(1-4)-β-D-glucopyranosyl-(1-4)-β-D-xylopyranoside；chloragin；(2S,3R,4S,5R)-2-[(2R,3S,4R,5R,6R)-6-[(3R,4R,5R,6S)-6-[(2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-methyl-6-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
• 化学式: C₅₅H₉₀O₂₅
• 分子量: 1151.3
• InChiKey: DJVPTSNYUANHAC-ADMFBXIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  80
• 可旋转键数：
  12
• 环数：
  11.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  374
• 氢给体数：
  13
• 氢受体数：
  25

反应信息

• 作为反应物：
  描述：

  tigogenin-3-O-α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-xylopyranoside 在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 剑麻皂素 、 D-木糖 、 6-脱氧-L-葡糖 、 葡萄糖
  参考文献：
  名称：

  Structure and activities of a steroidal saponin from Chlorophytum nimonii (Grah) Dalz

  摘要：

  A new steroidal saponin, chloragin (1), was isolated and characterised from the aerial part of Chlorophytum nimonii. The structure of chloragin (1) was established as tigogenin-3-O--L-rhamnopyranosyl-(1 4)--D-glucopyranosyl-(1 3)--D-xylopyranosyl-(1 4)--D-glucopyranosyl-(1 4)--D-xyloopyranoside on the basis of detailed chemical and spectral evidence. The saponin showed potent antihyperglycaemic and antidyslipidaemic activities in albino rats.

  DOI：

  10.1080/14786410902986597

文献信息

• Structure and activities of a steroidal saponin from <i>Chlorophytum nimonii</i> (Grah) Dalz
  作者：Vijai Lakshmi、Rajesh Kumar、Kartikey Pandey、Bhawani Shanker Joshi、Raja Roy、Kunnath Padamnabham Madhusudanan、Priti Tiwari、Arvind Kumar Srivastava

  DOI：10.1080/14786410902986597

  日期：2009.7.10

  A new steroidal saponin, chloragin (1), was isolated and characterised from the aerial part of Chlorophytum nimonii. The structure of chloragin (1) was established as tigogenin-3-O--L-rhamnopyranosyl-(1 4)--D-glucopyranosyl-(1 3)--D-xylopyranosyl-(1 4)--D-glucopyranosyl-(1 4)--D-xyloopyranoside on the basis of detailed chemical and spectral evidence. The saponin showed potent antihyperglycaemic and antidyslipidaemic activities in albino rats.