6H-indeno[2,1-b][1]benzofuran-6-one | 452962-67-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 6H-indeno[2,1-b][1]benzofuran-6-one
• 英文别名: benzo[b]indeno[1,2-d]furan-6-one；6H-indeno[2,1-b]benzofuran-6-one；Indeno[2,1-b][1]benzofuran-6-one
• CAS: 452962-67-3
• 化学式: C₁₅H₈O₂
• 分子量: 220.227
• InChiKey: BKSYVAQUPMXZFN-UHFFFAOYSA-N

物化性质

• 熔点：
  105-106 °C
• 沸点：
  388.9±11.0 °C(Predicted)
• 密度：
  1.361±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6H-indeno[2,1-b][1]benzofuran-6-one 在 氢氧化钾 、 一水合肼 作用下， 以 二乙二醇二甲醚 、 水 为溶剂， 以78%的产率得到6H-indeno[2,1-b][1]benzofuran
  参考文献：
  名称：

  Efficient Method for the Synthesis of Hetarenoindanones Based on 3-Arylhetarenes and Their Conversion into Hetarenoindenes

  摘要：

  A series of hetarenoindanones have been prepared by direct double metalation of the appropriate 3-phenylhetarene with butyllithium in the presence of TMEDA followed by treatment of the resulting dilithium compound with ethyl NiV-dimethylcarbamate. All hetarenoindanones were reduced according to Wolff-Kishner by hydrazine in the presence of KOH to the corresponding hetarenoindenes.

  DOI：

  10.1021/jo049504w
• 作为产物：
  描述：

  benzofuran-2-yl(2-bromophenyl)methanone 在 palladium diacetate 、 potassium carbonate 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到6H-indeno[2,1-b][1]benzofuran-6-one
  参考文献：
  名称：

  New method for the acylation of benzofurans toward the synthesis of 6H-indeno[2,1-b]benzofuran-6-ones and 2,2-bibenzofurans

  摘要：

  DOI：

  10.24820/ark.5550190.p011.624

文献信息

• PhI(OAc)₂–BF₃–OEt₂mediated domino imine activation, intramolecular C–C bond formation and β-elimination: new approach for the synthesis of fluorenones, xanthones and phenanthridines
  作者：Satinath Sarkar、Narender Tadigoppula

  DOI：10.1039/c4ra06159d

  日期：——

  PhI(OAc)2–BF3–OEt2 mediated domino synthesis of biologically important fluorenones, xanthones and phenanthridines has been developed. The reaction proceeds through imine activation, intramolecular C–C bond formation and β-elimination.

  已经开发出使用PhI(OAc)2–BF3–OEt2介导的生物重要的氟苯酮、黄酮和苯并吡啶的多重反应合成。该反应通过亚胺活化、分子内C–C键形成和β-消除进行。
• Synthesis of Fluoren-9-ones by the Palladium-Catalyzed Cyclocarbonylation of <i>o</i>-Halobiaryls
  作者：Marino A. Campo、Richard C. Larock

  DOI：10.1021/jo020140m

  日期：2002.8.1

  The synthesis of various substituted fluoren-9-ones has been accomplished by the palladium-catalyzed cyclocarbonylation of o-halobiaryls. The cyclocarbonylation of 4'-substituted 2-iodobiphenyls produces very high yields of 2-substituted fluoren-9-ones bearing either electron-donating or electron-withdrawing substituents. 3'-Substituted 2-iodobiphenyls afford 3-substituted fluoren-9-ones in excellent

  各种取代的芴-9-酮的合成已通过邻卤代联芳基的钯催化环羰基化完成。4′-取代的2-碘联苯的环羰基化产生非常高产率的带有给电子或吸电子取代基的2-取代的芴-9-。3'-取代的2-碘联苯以优异的产率和良好的区域选择性提供3-取代的芴-9-一。该化学方法已成功地扩展到多环芴酮和含有稠合异喹啉，吲哚，吡咯，噻吩，苯并噻吩和苯并呋喃环的芴酮。
• Efficient Method for the Synthesis of Hetarenoindanones Based on 3-Arylhetarenes and Their Conversion into Hetarenoindenes
  作者：Igor A. Kashulin、Ilya E. Nifant'ev

  DOI：10.1021/jo049504w

  日期：2004.8.1

  A series of hetarenoindanones have been prepared by direct double metalation of the appropriate 3-phenylhetarene with butyllithium in the presence of TMEDA followed by treatment of the resulting dilithium compound with ethyl NiV-dimethylcarbamate. All hetarenoindanones were reduced according to Wolff-Kishner by hydrazine in the presence of KOH to the corresponding hetarenoindenes.
• New method for the acylation of benzofurans toward the synthesis of 6H-indeno[2,1-b]benzofuran-6-ones and 2,2-bibenzofurans
  作者：Xuebing Zheng、Chuanjun Song、Yonggang Meng

  DOI：10.24820/ark.5550190.p011.624

  日期：——