dimethyl 2-(2-methoxy-2-oxo-1-phenylethyl)furan-3,4-dicarboxylate | 1316843-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: dimethyl 2-(2-methoxy-2-oxo-1-phenylethyl)furan-3,4-dicarboxylate
• CAS: 1316843-37-4
• 化学式: C₁₇H₁₆O₇
• 分子量: 332.31
• InChiKey: KJZYHGUPCPMJQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  92
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  苯甲酰甲酸甲酯 在 三乙烯二胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 dimethyl 2-(2-methoxy-2-oxo-1-phenylethyl)furan-3,4-dicarboxylate
  参考文献：
  名称：

  Microwave-Assisted Domino Access to C₂-Chain Functionalized Furans from Tertiary Propargyl Vinyl Ethers

  摘要：

  Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed Into trisubstituted C-2-chain functionalized furans. The metal-free domino transformation Involves a microwave-assisted tandem [3,3]propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed In a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols).

  DOI：

  10.1021/ol2017609

文献信息

• Microwave-Assisted Domino Access to C₂-Chain Functionalized Furans from Tertiary Propargyl Vinyl Ethers
  作者：David Tejedor、Leandro Cotos、Fernando García-Tellado

  DOI：10.1021/ol2017609

  日期：2011.8.19

  Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed Into trisubstituted C-2-chain functionalized furans. The metal-free domino transformation Involves a microwave-assisted tandem [3,3]propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed In a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols).