DMT-dU-Bn | 134958-69-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: DMT-dU-Bn
• 英文别名: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-phenylmethoxyoxolan-2-yl]pyrimidine-2,4-dione
• CAS: 134958-69-3
• 化学式: C₃₇H₃₆N₂O₇
• 分子量: 620.702
• InChiKey: ACXQUQYCVQOLIB-VUHKNJSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.44
• 重原子数：
  46.0
• 可旋转键数：
  12.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  101.01
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  DMT-dU-Bn 在 palladium on activated charcoal 氢气 、 sodium hydride 、 溶剂黄146 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 24.75h， 生成 dTp(CH3)dU
  参考文献：
  名称：

  Unraveling the origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites. A DNA synthesis building block for the cis-syn cyclobutane dimer of dTpdU.

  摘要：

  One possible origin of the major mutation induced by ultraviolet light, the C --> T transition at dTpdC sites, involves the replicative bypass of the cyclobutane dimer of dTpdC or its deamination product, the cis-syn dimer of dTpdU. In order to investigate the latter proposal, we have designed and synthesized a building block for the incorporation of the cis-syn dTpdU dimer into oligonucleotides by automated solid phase DNA synthesis technology.

  DOI：

  10.1016/s0040-4020(01)81791-9
• 作为产物：
  描述：

  保护-2'-脱氧尿苷 、 溴甲苯 在 sodium hydride 作用下， 生成 DMT-dU-Bn
  参考文献：
  名称：

  Unraveling the origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites. A DNA synthesis building block for the cis-syn cyclobutane dimer of dTpdU.

  摘要：

  One possible origin of the major mutation induced by ultraviolet light, the C --> T transition at dTpdC sites, involves the replicative bypass of the cyclobutane dimer of dTpdC or its deamination product, the cis-syn dimer of dTpdU. In order to investigate the latter proposal, we have designed and synthesized a building block for the incorporation of the cis-syn dTpdU dimer into oligonucleotides by automated solid phase DNA synthesis technology.

  DOI：

  10.1016/s0040-4020(01)81791-9