1-(2-氯乙酰基)-3-乙基脲 | 4791-24-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: 1-(2-氯乙酰基)-3-乙基脲
• 英文名称: 1-chloroacetyl-3-ethyl-urea
• 英文别名: N-ethyl-N'-chloroacetyl-urea；ClCH2C(O)NHC(O)NHCH2CH3；N-Aethyl-N'-chloracetyl-harnstoff；N-(chloroacetyl)-N'-ethylurea；N-Chloracetyl-N'-ethyl-harnstoff；1-(2-Chloro-acetyl)-3-ethyl-urea；2-chloro-N-(ethylcarbamoyl)acetamide
• CAS: 4791-24-6
• 化学式: C₅H₉ClN₂O₂
• mdl: MFCD00795992
• 分子量: 164.592
• InChiKey: BPSCQIPXTHOTMA-UHFFFAOYSA-N

物化性质

• 熔点：
  141.5-142.5 °C(Solv: benzene (71-43-2))
• 密度：
  1.225±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924210090

反应信息

• 作为反应物：
  描述：

  1-(2-氯乙酰基)-3-乙基脲 在 potassium sulfite 、 乙醇 作用下， 生成 (4-ethyl-allophanoyl)-methanesulfonic acid
  参考文献：
  名称：

  Andreasch, Monatshefte fur Chemie, 1922, vol. 43, p. 487

  摘要：

  DOI：
• 作为产物：
  描述：

  Cytochrome鎐frompigeonbreastmuscle 、 氯乙酰氯 在 苯 作用下， 生成 1-(2-氯乙酰基)-3-乙基脲
  参考文献：
  名称：

  Jacobs; Heidelberger; Rolf, Journal of the American Chemical Society, 1919, vol. 41, p. 460

  摘要：

  DOI：

文献信息

• [EN] IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES D'IMIDAZOPYRIDINE ET D'IMIDAZOPYRIMIDINE EN TANT QU'AGENTS ANTIBACTERIENS
  申请人：WARNER LAMBERT CO

  公开号：WO2005089763A1

  公开（公告）日：2005-09-29

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  公开了式I的化合物及其制备方法。进一步公开了制备式I生物活性化合物的方法，以及包含式I化合物的药用可接受组合物的方法。本文公开的式I化合物可用于各种应用，包括用作抗菌剂。
• IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Sciotti Richard John

  公开号：US20090275577A1

  公开（公告）日：2009-11-05

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文披露了化学式I的化合物及其制备方法。还披露了制备具有生物活性的化学式I化合物的方法，以及包含化学式I化合物的药学可接受组合物的方法。本文所披露的化学式I的化合物可用于多种应用，包括用作抗菌剂。
• Antibacterial agents
  申请人：Sciotti Richard John

  公开号：US20070191394A1

  公开（公告）日：2007-08-16

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文公开了化学式I的化合物及其制备方法。此外，还公开了制备生物活性化合物的方法，这些生物活性化合物的化学式为I，并且公开了包含化学式I化合物的药学上可接受的组合物的制备方法。本文所公开的化学式I的化合物可以在多种应用中使用，包括用作抗菌剂。
• Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents
  申请人：Pfizer Inc.

  公开号：US07563788B2

  公开（公告）日：2009-07-21

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文披露了化学式I的化合物及其制备方法。此外，还披露了制备生物活性化合物I的方法，以及包含化合物I的药学上可接受的组合物的方法。本文所披露的化合物I可用于各种应用，包括用作抗菌剂。
• Dinuclear platinum complexes with designer thiolate ligands from the monoalkylation of [Pt2(μ-S)2(PPh3)4]
  作者：Oguejiofo T. Ujam、Sarah M. Devoy、William Henderson、Brian K. Nicholson、T.S. Andy Hor

  DOI：10.1016/j.ica.2010.07.011

  日期：2010.10

  Alkylation reactions of the nucleophilic platinum(II) sulfide complex [Pt-2(mu- S)(2)(PPh3)(4)] with functionalised alkylating agents have been investigated as a versatile synthetic route to dinuclear, cationic sulfide-thiolate complexes of the type [Pt-2(mu-S)(mu-SR)(PPh3)(4)](+), extending the range of thiolate complexes that can be prepared using this methodology. A wide range of functional groups can be incorporated, using appropriate alkylating agents, and include ketone, ester, amide, hydrazone, semicarbazone, thiosemicarbazone, oxime, guanidine, urea and thiourea groups. (C) 2010 Elsevier B.V. All rights reserved.