N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
• 英文别名: N6-benzoyl-5'-O-(tert-bityldimethylsilyl)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine；N-[9-[(2R,4S,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]purin-6-yl]benzamide
• 化学式: C₄₄H₄₉N₅O₆Si
• 分子量: 771.988
• InChiKey: IFRXUMOICRTVSN-YXWIYCFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.78
• 重原子数：
  56
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以98%的产率得到N-苯甲酰基-3’-O-(4,4’-二甲氧基三苯甲基)-2’-脱氧腺苷
  参考文献：
  名称：

  Method for purifying 5'-protected 2'-deoxypurine nucleosides

  摘要：

  公开号：

  EP1253154B1
• 作为产物：
  描述：

  N-苯甲酰基-2’-脱氧腺苷 在 吡啶 作用下， 生成 N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
  参考文献：
  名称：

  Synthesis of 3′-Azido-3′-Deoxythymidine-Terminated Oligonucleotide

  摘要：

  A method of completely chemical synthesis of 3'-azido-3'-deoxythymidine-terminated oligonucleotides via 5'-H-phosphonate of AZT is described.

  DOI：

  10.1080/07328319808004703

文献信息

• Method for purifying 5' -protected 2' -deoxypurine nucleosides
  申请人：——

  公开号：US20030009028A1

  公开（公告）日：2003-01-09

  A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

  这是一种有效纯化5'保护的2'-去氧嘌呤核苷的方法，以前很难高效生产。通过获得5'保护的2'-去氧嘌呤核苷的包含晶体，包括具有腈结构的溶剂，可以分离杂质，以高纯度纯化5'保护的2'-去氧嘌呤核苷。这项发明使得以前只能通过柱层析法进行的大规模高纯度保护去氧嘌呤核苷的合成变得更加容易。
• Method for purifying 5′-protected 2′-deoxypurine nucleosides
  申请人：Komatsu Hironori

  公开号：US06958391B2

  公开（公告）日：2005-10-25

  A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

  一种高效纯化5'保护的2'-脱氧嘌呤核苷的方法，其高效生产先前曾经困难。通过获得包括具有腈结构的溶剂的包含晶体，可以分离杂质，以便高纯度地纯化5'保护的2'-脱氧嘌呤核苷。这项发明使得高纯度保护的脱氧嘌呤核苷易于大规模合成，这先前是通过柱层析法进行的。
• Method for purifying 5′ -protected 2′ -deoxypurine nucleosides
  申请人：Mitsui Chemicals, Inc.

  公开号：US07074917B2

  公开（公告）日：2006-07-11

  A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

  一种高效纯化5'保护的2'-去氧嘌呤核苷的方法，此前其高效生产一直很困难。可以通过得到包含有类似于腈的溶剂的包含晶体的5'保护的2'-去氧嘌呤核苷来分离杂质，以高纯度纯化5'保护的2'-去氧嘌呤核苷。这项发明使得高度纯化的保护去氧嘌呤核苷易于大规模合成，而此前一直采用柱层析法进行合成。
• Method for purifying 5'-protected 2'-deoxypurine nucleosides
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1253154B1

  公开（公告）日：2009-09-02
• Synthesis of 3′-Azido-3′-Deoxythymidine-Terminated Oligonucleotide
  作者：Dmitriy S. Esipov、Olga V. Esipova、Vyacheslav G. Korobko

  DOI：10.1080/07328319808004703

  日期：1998.9

  A method of completely chemical synthesis of 3'-azido-3'-deoxythymidine-terminated oligonucleotides via 5'-H-phosphonate of AZT is described.