7-fluoranthenecarbaldehyde | 96403-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-fluoranthenecarbaldehyde
• 英文别名: fluoranthene-7-carbaldehyde
• CAS: 96403-40-6
• 化学式: C₁₇H₁₀O
• 分子量: 230.266
• InChiKey: XRQRQDCKWNKQNL-UHFFFAOYSA-N

物化性质

• 沸点：
  438.2±14.0 °C(Predicted)
• 密度：
  1.326±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-fluoranthenecarbaldehyde 、 2-氨基-2-甲基-1,3-丙二醇 在 sodium cyanoborohydride 、 对甲苯磺酸 作用下， 生成 2-((7-荧基甲基)氨基)-2-甲基-1,3-丙烷二醇
  参考文献：
  名称：

  2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding

  摘要：

  The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA binding in a series of carbocyclic 2-[(arylmethyl)amino]-2-methyl-1,3-propanediols (AMAPs) were examined. In general, the interaction of AMAPs with DNA increases as the intercalating ring system grows in area, with three distinct binding levels evident. Isomers from a specific ring system appear to bind DNA similarly. DNA binding is not the sole criterion for antitumor activity for the AMAPs studied; the magnitude of the DELTA-T(m) does not correlate with the antitumor activity observed. Significant in vivo P388 activity was seen for AMAP congeners from several tetracyclic ring systems. However, isomers from each of the specific ring systems produced a wide range of in vivo P388 activity. Thus, AMAP antitumor activity is not a function of the ring system per se, but rather appears to be related to the shape of the specific molecule. Three AMAP congeners (crisnatol (770U82, 773U82, and 502U83) are currently in clinical trials.

  DOI：

  10.1021/jm00111a010
• 作为产物：
  描述：

  荧蒽 生成 7-fluoranthenecarbaldehyde
  参考文献：
  名称：

  BAIR, K. W.

  摘要：

  DOI：

文献信息

• Fluoranthene derivatives
  申请人：Burroughs Wellcome Co.

  公开号：US04720587A1

  公开（公告）日：1988-01-19

  The present invention relates to compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fluoranthene or substituted fluoranthene ring system; R.sup.1 contains not more than eight carbon carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-3 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five- or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  本发明涉及化合物的公式(I) ArCH.sub.2R.sup.1(I)或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，在总共不超过30个碳原子的情况下）; 它们的醚，酯; 酸加成盐; 其中Ar是芴或取代芴环系; R.sup.1含有不超过八个碳原子，并且是一个群 ##STR1## 其中m为0或1; R.sup.5是氢; R.sup.6和R.sup.7相同或不同，每个都是氢或C.sub.1-3烷基，可以选择地被羟基取代; R.sup.8和R.sup.9相同或不同，每个都是氢或C.sub.1-3烷基; ##STR2## 是一个五元或六元饱和碳环; R.sup.10是氢，甲基或羟甲基; R.sup.11，R.sup.12和R.sup.13相同或不同，每个都是氢或甲基; R.sup.14是氢，甲基，羟基或羟甲基。
• Dearomative Intramolecular Diels–Alder/Sulfur Extrusion Reaction of Thiophenes with Alkynes Using <i>peri</i>‐Substituted Naphthalene as a Tether
  作者：Takashi Okitsu、Yoshiki Shinohara、Haoran Luo、Manabu Hatano、Takayuki Yakura

  DOI：10.1002/asia.202301031

  日期：2024.2.16

  The naphthalene-tethered system enabled dearomative Diels–Alder/sulfur extrusion reaction of thiophenes and alkynes. Tri(o-tolyl)phosphine [P(o-tol)3] worked effectively as a sulfur scavenger to suppress the side reactions, and a wide range of fluoranthenes were obtained in moderate to excellent yields.

  萘系链系统能够实现噻吩和炔烃的脱芳香狄尔斯-阿尔德/硫挤出反应。三(邻甲苯基)膦[P( o -tol) 3 ]作为硫清除剂有效地抑制了副反应，并以中等至优异的产率获得了各种荧蒽。
• Polycyclic aromatic compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0125702B1

  公开（公告）日：1987-08-12
• BAIR, K. W.
  作者：BAIR, K. W.

  DOI：——

  日期：——
• US4532344A
  申请人：——

  公开号：US4532344A

  公开（公告）日：1985-07-30