1,8-Diguanidino-octan | 19010-48-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,8-Diguanidino-octan
• 英文别名: 1,8-Diguanidinooctane；N,N'''-octanediyl-di-guanidine；N,N'''-Octandiyl-di-guanidin；2-[8-(Diaminomethylideneamino)octyl]guanidine
• CAS: 19010-48-1
• 化学式: C₁₀H₂₄N₆
• 分子量: 228.341
• InChiKey: VUUYNASTGNDRSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  2

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  1,8-Diguanidino-octan 、 以 甲醇 、 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Enhancing Binding Affinity by the Cooperativity between Host Conformation and Host–Guest Interactions

  摘要：

  Glutamate-functionalized oligocholate foldamers bound Zn(OAc)(2), guanidine, and even amine compounds with surprisingly high affinities. The conformational change of the hosts during binding was crucial to the enhanced binding affinity. The strongest cooperativity between the conformation and guest-binding occurred when the hosts were unfolded but near the folding-unfolding transition. These results suggest that high binding affinity in molecular recognition may be more easily obtained from large hosts capable of strong cooperative conformational changes instead of those with rigid, preorganized structures.

  DOI：

  10.1021/ja203117g
• 作为产物：
  描述：

  4-胍基丁醛 在 乙醇 、 硫酸 作用下， 生成 1,8-Diguanidino-octan
  参考文献：
  名称：

  DE698728

  摘要：

  公开号：

文献信息

• [EN] COMPOUNDS AND USES FOR THE TREATMENT AND PREVENTION OF DISEASES AND CONDITIONS ASSOCIATE WITH OR AGGRAVATED BY IMPARED MITOPHAGY<br/>[FR] COMPOSÉS ET UTILISATIONS POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES ET D'ÉTATS ASSOCIÉS À UNE MITOPHAGIE DÉFICIENTE OU AGGRAVÉS PAR CELLE-CI
  申请人：YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD

  公开号：WO2019175873A1

  公开（公告）日：2019-09-19

  The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.

  本发明提供了用于治疗和预防与受损线粒体自噬有关或由其恶化的疾病和病况的化合物和方法。
• Agricultural and horticultural guanidine-type fungicide and process for production thereof
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0155509A1

  公开（公告）日：1985-09-25

  @ An agricultural and horticultural fungicide of low phytotoxicity comprising as an active ingredient an addition salt between a fungicidal guanidine compound and an acid having an oleophilic group with at least 9 carbon atoms in total. The acid addition salt is produced by reacting a fungicidal guanidine compound or its acid addition salt with an acid having an oleophilic group with at least 9 carbon atoms in total or its salt.

  一种植物毒性低的农用和园艺杀菌剂，其有效成分包括杀菌胍化合物与具有总共至少 9 个碳原子的亲油基团的酸之间的加成盐。 酸加成盐是由杀菌胍化合物或其酸加成盐与具有总共至少 9 个碳原子的亲油基团的酸或其盐反应生成的。
• Tertiary amine compounds
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0253498A2

  公开（公告）日：1988-01-20

  Compound of formula: and stereoisomers thereof, wherein R¹, R², R³ and R⁴ each represent a hydrogen atom, a halogen atom or an alkyl group containing from l to 4 carbon atoms, R⁵ and R⁶ each represent a hydrogen atom or an alkyl group containing from l to 4 carbon atoms, R⁷ and R⁸ each represent an alkyl group containing from l to 4 carbon atoms or R⁷ and R⁸ together with the adjacent nitrogen atom form a heterocyclic ring which may optionally contain an additional hetero atom, X and Y each represent a hydrogen atom, a halogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy or haloalkyl group, or a group wherein R⁹, R¹⁰ and R¹¹ can be alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, or aryl have plant fungicidal activity.

  式化合物及其立体异构体 及其立体异构体，其中 R¹、R²、R³ 和 R⁴ 各自代表氢原子、卤素原子或含有 l 至 4 个碳原子的烷基，R⁵ 和 R⁶ 各自代表氢原子或含有 l 至 4 个碳原子的烷基、R⁷ 和 R⁸ 各自代表含有 l 至 4 个碳原子的烷基，或 R⁷ 和 R⁸ 与相邻的氮原子一起形成杂环，该杂环可选择性地含有一个额外的杂原子， X 和 Y 各自代表氢原子、卤素原子或烷基、环烷基、环烷基烷基、烯基、炔基、芳基、芳烷基、烷氧基、芳氧基、芳氧基或卤代烷基，或一个基团。 其中 R⁹、R¹⁰ 和 R¹¹ 可以是烷基、烯基、炔基、环烷基、环烷基烷基或芳基的基团具有植物杀真菌活性。
• Fungicides
  申请人：ZENECA LIMITED

  公开号：EP0381330A1

  公开（公告）日：1990-08-08

  Fungicidal compounds of the formula (I): in which A and B are independently H, fluoro, chloro, bromo, C₁₋₄ alkyl, C₁₋₄ alkoxy or halo(C₁₋₄)alkyl provided that both are not H; D and E are independently H or fluoro; R¹ is H, C₁₋₄ alkyl or C₁₋₄ alkoxy; R² is C₁₋₄ alkyl, C₁₋₄ alkoxy or optionally substituted phenyl, or R¹ and R² together with the nitrogen atom to which they are attached join to form a morpholine, piperidine, pyrrolidine or azetidine ring which is optionally substituted with C₁₋₄ alkyl; R³ is H; R⁴ is trichloromethyl, C₂₋₈ alkyl (optionally substituted with halogen, C₁₋₈ alkoxy or R′S(O)n in which R′ is C₁₋₄ alkyl, C₂₋₄ alkenyl or C₂₋₄ alkynyl and n is 0, 1 or 2), cyclopropyl (optionally substituted with halogen or C₁₋₄ alkyl), C₂₋₈ alkenyl, C₂₋₈ alkynyl, C₁₋₈ alkoxy, mono- or di(C₁₋₄)alkyl- amino or the group, R˝ON=C(CN) in which R˝ is C₁₋₄ alkyl, or R³ and R⁴ together with the group C(O)N to which they are attached join to form an azetidin-2-one ring which is optionally substituted with halogen or C₁₋₄ alkyl; and X and Y are independently oxygen or sulphur.

  式 (I) 的杀真菌化合物： 其中 A 和 B 独立地为 H、氟、氯、溴、C₁₋₄ 烷基、C₁₋₄ 烷氧基或卤代(C₁₋₄)烷基，但两者均非 H；D 和 E 独立地为 H 或氟； R¹ 为 H、C₁₋₄ 烷基或 C₁₋₄ 烷氧基；R² 是 C₁₋₄烷基、C₁₋₄烷氧基或任选取代的苯基，或 R¹ 和 R² 与它们连接的氮原子一起形成吗啉环、哌啶环、吡咯烷环或氮杂环丁烷环，该环任选被 C₁₋₄ 烷基取代；R³ 是 H；R⁴是三氯甲基、C₂₋₈烷基（可选择被卤素取代）、C₁₋₈烷氧基或 R′S(O)n，其中 R′是 C₁₋₄烷基、C₂₋₈炔基、C₁₋₈烷氧基、单-或双(C₁₋₄)烷基-氨基或基团 R˝ON=C(CN)，其中 R˝ 是 C₁₋₄ 烷基、或 R³ 和 R⁴ 连同它们所连接的基团 C(O)N 形成一个氮杂环丁-2-酮环，该环可选择被卤素或 C₁₋₄ 烷基取代；X 和 Y 独立地为氧或硫。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。