[Co(N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine(-2H))] | 76972-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [Co(N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine(-2H))]
• 英文别名: 4,4′-((1E,1′E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene))bis(benzene-1,3-diol)cobalt(II)；Co((OH)2saloph)
• CAS: 76972-01-5
• 化学式: C₂₀H₁₄CoN₂O₄
• 分子量: 405.335
• InChiKey: KAUZWFNXAIOZEY-XHPUXTPKSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  邻苯二胺 、 2,4-二羟基苯甲醛 以 甲醇 为溶剂， 反应 3.0h， 生成 [Co(N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine(-2H))]
  参考文献：
  名称：

  设计，合成和生物学评估钴（II）-席夫碱配合物作为ATP-非竞争性MEK1抑制剂。

  摘要：

  在本报告中，我们设计并合成了一系列具有有效MEK1（促分裂原活化蛋白激酶激酶-1）抑制活性的钴（II）-席夫碱复合物（CoSBC）。根据我们先前的报道，CoSBC与MEK1蛋白具有很高的结合亲和力。为了进一步探索作为MEK1抑制剂的金属配合物，采用了一系列过渡金属和配体来构建各种金属席夫碱配合物的文库。MEK抑制试验表明，只有CoSBC表现出明显的抑制活性，复合物2b在BRaf（B迅速加速的纤维肉瘤）/ MEK1和MEK1 / ERK2（细胞外信号调节激酶-2）级联反应中均表现出最好的抑制作用（IC 50分别为1.988±0.14μM和1.589±0.054μM）。此外，采用均相时间分辨荧光测试方法证明了CoSBC是ATP非竞争性MEK1抑制剂。MEK激酶选择性测定表明，CoSBC可以选择性抑制MEK1 / 2激酶，而不是其他MAPK（促分裂原激活的蛋白激酶）家族激酶。此外，计算机辅助药物

  DOI：

  10.1016/j.jinorgbio.2019.03.022

文献信息

• Activities of Co(II) Schiff base complexes in the redox carbonylation of aniline and nitrobenzene to methyl N-phenyl carbamate
  作者：Li-juan Chen、Fu-ming Mei、Guang-xing Li、Yu-jun Xiang

  DOI：10.1134/s0023158410050083

  日期：2010.10

  The series of cobalt(II) complexes with different Schiff base ligands was synthesized and used as catalyst for the redox carbonylation of aniline and nitrobenzene. Effects of reaction temperature, CO pressure, promoter, and catalyst additions on the conversion of substrate were studied. When Co[(OH)2saloph] — p-toluenesulfonic acid system was used as catalyst, the reaction was carried out at the next

  合成了具有不同席夫碱配体的一系列钴（II）配合物，并将其用作苯胺和硝基苯的氧化羰基化催化剂。研究了反应温度，CO压力，助催化剂和催化剂添加量对底物转化率的影响。当使用Co [（OH）2 saloph]-对甲苯磺酸体系作为催化剂时，反应在以下条件下进行：Co [（OH）2 saloph]和对甲苯磺酸-0.2 mmol，苯胺- 20 mmol，硝基苯-10 mmol，甲醇-30 ml，Co-5 MPa，温度170°C，反应时间7 h。硝基苯的最高转化率和N-苯基氨基甲酸甲酯的选择性分别为54.5％和92.2％。
• Cobalt(II) Schiff base complex on multi-wall carbon nanotubes (MWNTs) by covalently grafted method: Synthesis, characterization and liquid phase epoxidation of cyclohexene by air
  作者：Masoud Salavati-Niasari、Elahe Esmaeili、Hamideh Seyghalkar、Mehdi Bazarganipour

  DOI：10.1016/j.ica.2011.03.056

  日期：2011.9

  Cobalt [(OH)(2)-salophen] (N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine) complex was covalently grafted on the chemical modification of multi-wall carbon nanotubes (MWNTs); [Co((OH)(2)-salophen)]@MWNTs]. The as-products were characterized by spectroscopy (FT-IR, Raman, and UV-Vis), TGA, and TEM. The cobalt(II) Schiff-base complex covalently anchored on modified MWNTs was characterized by different techniques. The catalytic activity of the novel nanotubes based materials was tested in the epoxidation of cyclohexene in the iso-butyraldehyde/air system using acetonitrile as solvent and very high conversion was obtained. The experimental results indicated very good catalytic activity and selectivity in the epoxidation of cyclohexene. Repeated runs of the catalysts were carried out three times and the results indicated that the catalyst was stable for the epoxidation of cyclohexene. (C) 2011 Elsevier B.V. All rights reserved.
• Sailaja; Radhakrishna Reddy; Mohana Raju, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1999, vol. 38, # 2, p. 156 - 160
  作者：Sailaja、Radhakrishna Reddy、Mohana Raju、Hussain Reddy

  DOI：——

  日期：——