trans-4-chlorocyclohexane carboxylic acid | 56447-20-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: trans-4-chlorocyclohexane carboxylic acid
• 英文别名: 4-chlorocyclohexanecarboxylic acid methyl ester；4-chloro-1-cyclohexanecarboxylic acid；4-Chlor-1-cyclohexancarbonsaeure；4-Chlorocyclohexane-1-carboxylic acid
• CAS: 56447-20-2
• 化学式: C₇H₁₁ClO₂
• 分子量: 162.616
• InChiKey: HCNHIDFPSXEDAV-UHFFFAOYSA-N

物化性质

• 熔点：
  109.5 °C(Solv: water (7732-18-5))
• 沸点：
  296.6±33.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-4-chlorocyclohexane carboxylic acid 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 4-氯环己烷羰基氯化物
  参考文献：
  名称：

  6-(Substituted-cycloalkylcarboxamide) penicillanic acids

  摘要：

  盐酸盐或药用可接受的非毒性盐的公式为##SPC1##的青霉素，其中R.sub.1和R.sub.2相同或不同，每个都是氢、氟、氯或溴；或者当R.sub.2是氢时，R.sub.1也可以是氰基、羟基、叠氮基、氨基或硝基；或者R.sub.1和R.sub.2连接到一个环碳原子并构成一个单氧原子；R.sub.3是氢、甲基、氯、溴、氰基、甲氧基或羧基；n为2到7；它们因其抗菌活性而有用。

  公开号：

  US03954730A1
• 作为产物：
  描述：

  3-环己烯-1-甲酸 、 盐酸 生成 trans-4-chlorocyclohexane carboxylic acid
  参考文献：
  名称：

  ISMAJLOV A. G.; GASHIMOV G. A.; PYCTAMOB M. A., AZEHRB. KIMJA ZH., AZERB. XIM. ZH., 1979, HO 6, 58-61

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCING ESTER COMPOUND
  申请人：Imazeki Shigeaki

  公开号：US20100324314A1

  公开（公告）日：2010-12-23

  PROBLEM To provide an environmentally-friendly method for producing industrially an ester compound. SOLUTION The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.

  问题提供一种生产工业酯化合物的环保方法。 解决方案是一种生产酯化合物的方法，包括将羧酸和醇经过脱水缩合反应，使用一种不挥发的酸催化剂，然后通过将弱碱性物质与残留的酸催化剂接触来去除残留的酸催化剂。
• Trifluoro-2-(trans-4-substituted cyclohexyl) ethylenes and process for
  申请人：Asahi Glass Company Ltd.

  公开号：US05621147A1

  公开（公告）日：1997-04-15

  A 1,1,2-trifluoro-2-(trans-4-substituted cyclohexyl)ethylene of the formula (1): R--(A).sub.m --Cy--CF=CF.sub.2 (1) wherein R is a C.sub.1-10 alkyl group, a halogen atom or a cyano group, provided that in the case of the alkyl group, an oxygen atom may be interposed in a carbon-carbon bond of the alkyl group or in a carbon-carbon bond between this alkyl group and A, some of carbon-carbon bonds in the alkyl group may be triple bonds or double bonds, one --CH.sub.2 -- group in the alkyl group may be substituted by a carbonyl group, and some or all of hydrogen atoms in the alkyl group may be substituted by fluorine atoms; Cy is an unsubstituted trans-1,4-cyclohexylene group; A is a trans-1,4-cyclohexylene group, a 1,4-phenylene group or a 1,4-cyclohexenylene group, wherein each of such cyclic groups is unsubstituted or substituted by one or more halogen atoms or cyano groups, one or more =CH-- groups constituting rings of such cyclic groups may be substituted by nitrogen atoms, and one or more --CH.sub.2 -- groups constituting rings of such cyclic groups may be substituted by oxygen atoms or sulfur atoms; and m is 0 or 1.

  该公式为：R--(A).sub.m --Cy--CF=CF.sub.2 (1)，其中R是一个C.sub.1-10烷基基团、一个卤素原子或一个氰基团，但是在烷基基团的情况下，氧原子可以插入烷基基团的碳-碳键或者在该烷基基团和A之间的碳-碳键中，烷基基团中的一些碳-碳键可以是三键或双键，烷基基团中的一个--CH.sub.2--基团可以被羰基取代，烷基基团中的一些或全部氢原子可以被氟原子取代；Cy是一个未取代的反式1,4-环己基基团；A是一个反式1,4-环己基基团、一个1,4-苯基基团或一个1,4-环己烯基基团，其中这些环状基团中的每一个未取代或被一个或多个卤素原子或氰基团取代，构成这些环状基团的一个或多个=CH--基团可以被氮原子取代，构成这些环状基团的一个或多个--CH.sub.2--基团可以被氧原子或硫原子取代；m为0或1。
• Heterocycle-bearing onium salts
  申请人：Ishihara Masami

  公开号：US20050233253A1

  公开（公告）日：2005-10-20

  The present invention relates to a heterocycle-containing onium salt useful as, for example, a cationic photopolymerization initiator and an acid generator for a chemically amplified resist, and provides “a heterocycle-containing onium salt shown by the general formula [1]: [wherein R is a group shown by the general formula [2]: (wherein R 3 and R 4 are each independently a halogen atom, an alkyl group which may have a halogen atom or an aryl group as a substituent, or an aryl group which may have a halogen atom or a lower alkyl group as a substituent; X 2 is an oxygen atom or a sulfur atom; i is an integer of 0 to 4; and j is an integer of 0 to 3), or a group shown by the general formula [3]: (wherein R 5 and R 6 are each independently a halogen atom, an alkyl group which may have a halogen atom or an aryl group as a substituent, or an aryl group which may have a halogen atom or a lower alkyl group as a substituent; X 3 and X 4 are each independently an oxygen atom or a sulfur atom; p is an integer of 0 to 2; and q is an integer of 0 to 3); R 1 and R 2 are each independently a halogen atom, an alkyl group which may have a halogen atom or an aryl group as a substituent, or an aryl group which may have a halogen atom or a lower alkyl group as a substituent; m and n are each independently an integer of 0 to 5; and A is a halogen atom or an anion derived from an inorganic strong acid, an organic acid or a compound shown by the general formula [4]: HM 1 (R 7 ) 4 [4] (wherein M 1 is a boron atom or a gallium atom; and R 7 is an aryl group which may have a substituent selected from a lower haloalkyl group, a halogen atom, a nitro group and a cyano group)]” or “a heterocycle-containing onium salt shown by the general formula [35]: [wherein R 26 and R 27 are each independently an aryl group which may have a halogen atom or a lower alkyl group as a substituent, a group shown by the above-mentioned general formula [2], or a group shown by the above-mentioned general formula [3]; and A 3 is a halogen atom or an anion derived from an inorganic strong acid, an organic acid or a compound shown by the general formula [4]; and provided that at least one of R 26 and R 27 is a group shown by the above-mentioned general formula [2] or [3], and when only one of R 26 and R 27 is a group shown by the above-mentioned general formula [2] or [3], A 3 is an anion derived from an inorganic strong acid shown by the general formula [36]; HM 3 F 6 [36] (wherein M 3 is a phosphorus atom, an arsenic atom or an antimony atom), an organic acid or a compound shown by the general formula [4]]”.

  本发明涉及一种含杂环离子盐，例如，用作阳离子光聚合引发剂和化学增感抗蚀剂的酸发生剂，并提供“一种由通式[1]所示的含杂环离子盐：[其中R是由通式[2]所示的基团：（其中R3和R4分别独立地是卤素原子，可能具有卤素原子或芳基取代基的烷基基团，或可能具有卤素原子或较低烷基基团的芳基基团；X2是氧原子或硫原子；i是0到4的整数；j是0到3的整数），或由通式[3]所示的基团：（其中R5和R6分别独立地是卤素原子，可能具有卤素原子或芳基取代基的烷基基团，或可能具有卤素原子或较低烷基基团的芳基基团；X3和X4分别独立地是氧原子或硫原子；p是0到2的整数；q是0到3的整数）；R1和R2分别独立地是卤素原子，可能具有卤素原子或芳基取代基的烷基基团，或可能具有卤素原子或较低烷基基团的芳基基团；m和n分别独立地是0到5的整数；A是从无机强酸，有机酸或由通式[4]所示的化合物得到的卤素离子或阴离子：HM1（R7）4[4]（其中M1是硼原子或镓原子；R7是可能选择自较低卤代烷基基团、卤素原子、硝基基团和氰基团的芳基基团）]”或“一种由通式[35]所示的含杂环离子盐：[其中R26和R27分别独立地是可能具有卤素原子或较低烷基基团的芳基基团，上述通式[2]所示的基团或上述通式[3]所示的基团；A3是从无机强酸，有机酸或由通式[4]所示的化合物得到的卤素离子或阴离子；并且至少其中之一的R26和R27是上述通式[2]或[3]所示的基团，当仅R26和R27中的一个是上述通式[2]或[3]所示的基团时，A3是从通式[36]所示的无机强酸得到的阴离子：HM3F6[36]（其中M3是磷原子、砷原子或锑原子），有机酸或由通式[4]所示的化合物]”。
• Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
  申请人：University of Illinois Foundation

  公开号：EP0048149A1

  公开（公告）日：1982-03-24

  Novel antibiotics named didenmins A, B and C and nordidemnins A, B and C have been obtained from a marine organism named Trididemnum sp. These antibiotics are active against a variety of DNA and RNA viruses.

  从一种名为 Trididemnum sp.的海洋生物中获得了名为 didenmins A、B 和 C 以及 nordidemnins A、B 和 C 的新型抗生素。
• Glycosides isolated from the Euphorbiaceae genus Phyllanthus and their anti-tumour use
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0087861A1

  公开（公告）日：1983-09-07

  New antineoplastic glycosides, phyllanthostatin 1,2 and 3, of formula: and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.

  从中美洲树种 Phyllanthus acuminatus Vahl 中分离出了新的抗肿瘤苷--式：的 phyllanthostatin 1、2 和 3，以及相关的苷--phyllanthoside。 这些化合物对美国国家癌症研究所的 P388 淋巴细胞白血病具有活性。 此外，还发现 phyllanthoside 对小鼠 B16 恶性肿瘤具有治疗活性。