C20 dihydrosphingosine | 24028-07-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: C20 dihydrosphingosine
• 英文别名: threo-1,3-Dihydroxy-2-amino-eikosan；2-Aminoicosane-1,3-diol
• CAS: 24028-07-7
• 化学式: C₂₀H₄₃NO₂
• 分子量: 329.567
• InChiKey: UFMHYBVQZSPWSS-UHFFFAOYSA-N

物化性质

• 熔点：
  89-91 °C(Solv: chloroform (67-66-3); ethyl ether (60-29-7))
• 沸点：
  471.9±25.0 °C(Predicted)
• 密度：
  0.920±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二氯乙酸甲酯 、 C20 dihydrosphingosine 生成 DL-erythro-N-Dichloracetyl-1,3-dihydroxy-2-amino-eikosan
  参考文献：
  名称：

  Zeonkova,E.N. et al., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, p. 199 - 201

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Amino-3-oxo-eikosansaeure-ethylester-hydrochlorid 在 lithium aluminium tetrahydride 作用下， 生成 C20 dihydrosphingosine
  参考文献：
  名称：

  Zeonkova,E.N. et al., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, p. 199 - 201

  摘要：

  DOI：

文献信息

• Compositions and methods for treating hyperproliferative disorders
  申请人：TEXAS TECH UNIVERSITY

  公开号：EP2669267A1

  公开（公告）日：2013-12-04

  A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.; A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred hyperproliferative disorder is brain cancers.

  一种治疗需要这种治疗的受试者的过度增殖性疾病的方法，包括向所述受试者联合施用治疗有效量的以下物质：(a) 神经酰胺增加型维甲酸，如芬瑞替尼或其药学上可接受的盐；(b) 至少一种（在某些实施方案中至少两种）选自以下组别的化合物：(i) 非 18 碳链长度的 L-苏-鞘氨醇或其药学上可接受的盐；(ii) 葡萄糖甘油酰胺或葡萄糖（二氢）神经酰胺合成抑制剂；(iii) 鞘磷脂或二氢鞘磷脂合成酶抑制剂。优选的 L-硫代鞘磷脂的碳链长度为 17 碳、19 碳和 20 碳。一种优选的葡糖基甘油酰胺或葡糖基（二氢）神经酰胺合成抑制剂是 D-苏-1-苯基-2-棕榈酰氨基-3-吗啉基-1-丙醇；一种优选的鞘磷脂或二氢鞘磷脂合成抑制剂是 D-苏-1-苯基-2-棕榈酰氨基-3-吗啉基-1-丙醇。一种优选的过度增殖性疾病是脑癌。
• COMPOSITION FOR SURFACE MODIFICATION
  申请人：LG Household & Health Care Ltd.

  公开号：EP3342395A2

  公开（公告）日：2018-07-04

  The present invention relates to a composition for surface modification. The composition for surface modification according to the present invention contains a particular carbodiimide-based compound, thus forms a covalent bond without damaging skin, hair, or fabric, and semipermanently provides desired skin or hair surface modification effects or fabric care effects.

  本发明涉及一种用于表面修饰的组合物。根据本发明，用于表面改性的组合物含有一种特定的碳化二亚胺基化合物，从而在不损伤皮肤、头发或织物的情况下形成共价键，并半永久性地提供所需的皮肤或头发表面改性效果或织物护理效果。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3604269A1

  公开（公告）日：2020-02-05

  The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a target cell using the extracted compounds or a plurality of combinations and promoting the nucleic acid to enter required target sites in vivo of an object.

  本申请涉及从中药中提取多种能够促使核酸递送的化合物或合成化合物，并利用提取的化合物或多种组合促进核酸（如 sRNA）吸收并进入靶细胞，并促进核酸进入物体体内所需的靶位点。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3778556A1

  公开（公告）日：2021-02-17

  The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and the entry thereof into a target cell by using the extracted compounds or multiple combinations, and promoting the entry of the nucleic acid into a target site in an object body having such a need. The traditional Chinese medicine is selected from traditional Chinese medicine decoction pieces derived from Rhodiola rosea, Herba Taraxaci, Herba andrographitis, and Flos Lonicerae. The nucleic acid is used for treating diseases, such as heart, spleen, kidney, stomach, lung and/or bowel diseases.

  本发明涉及从中药中提取能够促进核酸递送的多种化合物或合成化合物，利用提取的化合物或多种组合促进sRNA等核酸的吸收及其进入靶细胞，并促进核酸进入有此需要的物体体内的靶位点。所述中药选自红景天、蒲公英、穿心莲、忍冬藤等中药的煎煮片。核酸用于治疗疾病，如心、脾、肾、胃、肺和/或肠疾病。
• EXTRACTION OF PLANT SOURCE "MEDICINAL SOUP" AND MANUAL PREPARATION OF "HERBAL MEDICINE" AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3789043A1

  公开（公告）日：2021-03-10

  Provided is a preparation method for herbal medicine, comprising the following steps: mixing one or more lipid components and/or with any one or more of the following: nucleic acid, compounds, and macromolecules; and performing heat treatment on the obtained mixture. Also provided is a method for extracting medicinal soup from plants, comprising the following steps: using a solvent to prepare extract solution of a plant; performing differential centrifugation of the extract solution; and using an aqueous solution to re-suspend the precipitate to provide the medicinal soup.

  本发明提供了一种中草药的制备方法，包括以下步骤：将一种或多种脂质成分和/或与以下任一种或多种成分混合：核酸、化合物和大分子；对得到的混合物进行热处理。还提供了一种从植物中提取药汤的方法，包括以下步骤：使用溶剂制备植物提取液；对提取液进行差速离心；以及使用水溶液重新悬浮沉淀，以提供药汤。