(2,4-dichloro-[1]naphthyl)-methyl ether | 67061-68-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2,4-dichloro-[1]naphthyl)-methyl ether
• 英文别名: (2,4-Dichlor-[1]naphthyl)-methyl-aether；2.4-Dichlor-naphthol-(1)-methylaether；2.4-Dichlor-1-methoxy-naphthalin；2,4-Dichlor-1-methoxynaphthalin；2,4-Dichloro-1-methoxynaphthalene
• CAS: 67061-68-1
• 化学式: C₁₁H₈Cl₂O
• 分子量: 227.09
• InChiKey: SMNLNHLWUBUPAT-UHFFFAOYSA-N

物化性质

• 沸点：
  334.3±22.0 °C(Predicted)
• 密度：
  1.324±0.06 g/cm3(Predicted)
• 保留指数：
  1670

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,4-二氯-1-萘醇 生成 (2,4-dichloro-[1]naphthyl)-methyl ether
  参考文献：
  名称：

  通过气相色谱质谱法鉴定羟基化的氯二苯并-对-二恶英，氯二苯并呋喃，氯二苯醚和氯萘为甲基醚。

  摘要：

  合成了代表所有不同羟基取代基的许多羟基化（聚）氯二苯并-对-二恶英，氯二苯并呋喃，氯二苯醚和氯萘的甲基醚，并对其质谱进行了研究。除了氯二苯并呋喃的甲氧基衍生物外，似乎每一类化合物的结构异构体的质量碎裂模式都是非常特异性的，并且可以明确分配分子中甲氧基的位置。可以根据导致稳定的电荷离域（oxonium）离子的合理机理来解释不同的碎裂模式。由于其诊断价值，该方法可用于阐明氯二苯并-对-二恶英的纯异构体的羟基化代谢物的结构，

  DOI：

  10.1002/bms.1200050311

文献信息

• Franzen; Staeuble, Journal fur praktische Chemie (Leipzig 1954), 1921, vol. <2> 103, p. 367
  作者：Franzen、Staeuble

  DOI：——

  日期：——
• HIGHLY EFFICIENT, PARA-SELECTIVE OXYCHLORINATION OF AROMATIC COMPOUNDS USING POTASSIUM CHLORIDE AND OXONE®*
  作者：N. Narender、P. Srinivasu、S. J. Kulkarni、K. V. Raghavan

  DOI：10.1081/scc-120002013

  日期：2002.1

  A highly efficient, regioselective method for oxychlorination of aromatic compounds is possible through electrophilic substitution of chlorine generated in situ from KCl as a chlorine source and Oxone(R) as an oxidant for the first time.
• MUTANT ANTIBODIES AND CONJUGATION THEREOF
  申请人：Pfizer Healthcare Ireland

  公开号：US20210147576A1

  公开（公告）日：2021-05-20

  The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X 1 -X 2 -X 3 -X 4 -K 5 H 6 (SEQ ID NO:98), and X 1 , X 3 and X 4 are each independently any amino acid residue, characterized in that X 2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof
• Identification of hydroxylated chlorodibenzo-p-dioxins, chlorodibenzofurans, chlorodiphenyl ethers and chloronaphthalenes as their methyl ethers by gas chromatography mass spectrometry
  作者：Martin Th. M. Tulp、Otto Hutzinger

  DOI：10.1002/bms.1200050311

  日期：1978.3

  The methyl ethers of a number of hydroxylated (poly)chlorodibenzo-p-dioxins, chlorodibenzofurans, chlorodiphenyl ethers and chloronaphthalenes, representing all different hydroxy substitutions, were synthesized and their mass spectra investigated. With the exception of the methoxy derivatives of the chlorodibenzofurans, it appeared that the mass fragmentation patterns of the structural isomers of each

  合成了代表所有不同羟基取代基的许多羟基化（聚）氯二苯并-对-二恶英，氯二苯并呋喃，氯二苯醚和氯萘的甲基醚，并对其质谱进行了研究。除了氯二苯并呋喃的甲氧基衍生物外，似乎每一类化合物的结构异构体的质量碎裂模式都是非常特异性的，并且可以明确分配分子中甲氧基的位置。可以根据导致稳定的电荷离域（oxonium）离子的合理机理来解释不同的碎裂模式。由于其诊断价值，该方法可用于阐明氯二苯并-对-二恶英的纯异构体的羟基化代谢物的结构，