N-(3-methoxy-phenyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide | 3908-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(3-methoxy-phenyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide
• 英文别名: N-(3-methoxyphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
• CAS: 3908-96-1
• 化学式: C₂₃H₃₀N₂O₂
• 分子量: 366.503
• InChiKey: WROUPEFUZYYTIF-UHFFFAOYSA-N

物化性质

• 沸点：
  508.9±50.0 °C(Predicted)
• 密度：
  1.099±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-methoxy-phenyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide 在 盐酸小檗碱 作用下， 生成 N-(3-Hydroxy-phenyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide
  参考文献：
  名称：

  Lobbezoo; Soudijn; Van Wijngaarden, European Journal of Medicinal Chemistry, 1980, vol. 15, # 4, p. 357 - 361

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-苯乙基)-4-哌啶酮 在 sodium tetrahydroborate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-(3-methoxy-phenyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide
  参考文献：
  名称：

  PEGYLATED OPIOID WITH LOW ADDICTIVE EFFECT

  摘要：

  公开号：

  EP3409295B1

文献信息

• [EN] COMPOSITIONS, DOSAGE FORMS, AND COADMINISTRATION OF AN OPIOID AGONIST COMPOUND AND AN ANALGESIC COMPOUND<br/>[FR] COMPOSITIONS, FORMES GALÉNIQUES ET COADMINISTRATION D'UN COMPOSÉ AGONISTE OPIOÏDE ET D'UN COMPOSÉ ANALGÉSIQUE
  申请人：NEKTAR THERAPEUTICS

  公开号：WO2013070617A1

  公开（公告）日：2013-05-16

  The present invention relates generally to the co-administration of an opioid agonist compound and an analgesic compound. In addition, the invention relates to, among other things, dosage forms for co-administration of an opioid agonist compound and an analgesic compound, methods for administering an opioid agonist compound and an analgesic compound, compositions comprising an opioid agonist compound and an analgesic compound, dosage forms comprising an opioid agonist compound and an analgesic compound, and so on.

  本发明一般涉及阿片受体激动剂化合物和镇痛化合物的联合给药。此外，该发明涉及阿片受体激动剂化合物和镇痛化合物的联合给药的剂型，给药阿片受体激动剂化合物和镇痛化合物的方法，包含阿片受体激动剂化合物和镇痛化合物的组合物，包含阿片受体激动剂化合物和镇痛化合物的剂型等。
• Compositions, Dosage Forms, and Co-Administration of an Opioid Agonist Compound and an Analgesic Compound
  申请人：Nektar Therapeutics

  公开号：US20170079975A1

  公开（公告）日：2017-03-23

  The present invention relates generally to the co-administration of an opioid agonist compound and an analgesic compound. In addition, the invention relates to, among other things, dosage forms for co-administration of an opioid agonist compound and an analgesic compound, methods for administering an opioid agonist compound and an analgesic compound, compositions comprising an opioid agonist compound and an analgesic compound, dosage forms comprising an opioid agonist compound and an analgesic compound, and so on.

  本发明一般涉及阿片受体激动剂化合物和镇痛化合物的联合给药。此外，该发明涉及阿片受体激动剂化合物和镇痛化合物的联合给药剂型，给药阿片受体激动剂化合物和镇痛化合物的方法，包括阿片受体激动剂化合物和镇痛化合物的组合物，包括阿片受体激动剂化合物和镇痛化合物的剂型，等等。
• Oligomer-Opioid Agonist Conjugates
  申请人：Riggs-Sauthier Jennifer

  公开号：US20100048602A1

  公开（公告）日：2010-02-25

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。该发明的化合物在通过任何一种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• OLIGOMER-OPIOID AGONIST CONJUGATES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20150112069A1

  公开（公告）日：2015-04-23

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。该发明的化合物在通过多种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• Oligomer-opioid agonist conjugates
  申请人：Nektar Therapeuitcs

  公开号：US10307416B2

  公开（公告）日：2019-06-04

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  本发明提供了通过共价连接水溶性低聚物进行化学修饰的化合物。本发明的化合物在通过多种给药途径中的任何一种给药时，会表现出与未附着水溶性低聚物的化合物不同的特性。