8-methoxy-2-methyl-3,4-dihydro-1H-naphthalene-2-carboxylic acid | 113271-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-methoxy-2-methyl-3,4-dihydro-1H-naphthalene-2-carboxylic acid
• CAS: 113271-26-4
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: RHWNOGFRGNKGRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-methoxy-2-methyl-3,4-dihydro-1H-naphthalene-2-carboxylic acid 以35%的产率得到
  参考文献：
  名称：

  MELLIN, CHARLOTTA;YE, LIU;HACKSELL, ULI;BJORK, LENA;ANDEN, NILS-ERIK, ACTA PHARM. SUEC., 24,(1987) N 4, 153-160

  摘要：

  DOI：
• 作为产物：
  描述：

  8-甲氧基-1,2,3,4-四氢萘-2-羧酸甲酯 在 lithium hydroxide 、 lithium diisopropyl amide 作用下， 生成 8-methoxy-2-methyl-3,4-dihydro-1H-naphthalene-2-carboxylic acid
  参考文献：
  名称：

  Structure–activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists

  摘要：

  The structure-activity relationship studies on a series of tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists are discussed. It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.026

文献信息

• MELLIN, CHARLOTTA;YE, LIU;HACKSELL, ULI;BJORK, LENA;ANDEN, NILS-ERIK, ACTA PHARM. SUEC., 24,(1987) N 4, 153-160
  作者：MELLIN, CHARLOTTA、YE, LIU、HACKSELL, ULI、BJORK, LENA、ANDEN, NILS-ERIK

  DOI：——

  日期：——
• Structure–activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists
  作者：Hongyu Zhao、Zhili Xin、Jyoti R. Patel、Lissa T.J. Nelson、Bo Liu、Bruce G. Szczepankiewicz、Verlyn G. Schaefer、H. Douglas Falls、Wiweka Kaszubska、Christine A. Collins、Hing L. Sham、Gang Liu

  DOI：10.1016/j.bmcl.2005.02.026

  日期：2005.4

  The structure-activity relationship studies on a series of tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists are discussed. It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists. (c) 2005 Elsevier Ltd. All rights reserved.