R 1-(1,2,3,4-tetrahydronaphthyl)-homopiperazine | 228255-89-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: R 1-(1,2,3,4-tetrahydronaphthyl)-homopiperazine
• 英文别名: 1-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,4-diazepane
• CAS: 228255-89-8
• 化学式: C₁₅H₂₂N₂
• 分子量: 230.353
• InChiKey: VIZVUUXHGLJMQQ-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  R 1-(1,2,3,4-tetrahydronaphthyl)-homopiperazine 、 异丁酸 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 生成 1-(1,2,3,4-Tetrahydronaphthyl)-4-(2-methylpropyl)homopiperazine
  参考文献：
  名称：

  1,4-diazacycloheptane derivatives

  摘要：

  这项发明提供了在治疗神经系统疾病中有用的取代1,2,3,4-四氢萘[3H]-埃莫帕米结合位点抑制剂。这些抑制剂是具有以下式(I)的化合物，其中R、R1、m、R2和n如规范中定义的。该发明还提供含有这些化合物的药物组合物、使用这些化合物的方法以及制备这些化合物的方法。

  公开号：

  US06417183B1

文献信息

• 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：AstraZeneca AB

  公开号：EP1140863A1

  公开（公告）日：2001-10-10
• 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS
  申请人：AstraZeneca UK Limited

  公开号：EP1192141A1

  公开（公告）日：2002-04-03
• [EN] 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] DERIVES DE 1,4-DIAZACYCLOHEPTANE, UTILES DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000039105A1

  公开（公告）日：2000-07-06

  Tetrahydronaphthylhomopiperazines of formula (I), wherein p is 4 and R1 at each occurrence is independently selected from hydrogen, halo, hydroxy, C¿1-6?alkyl, C1-6alkoxy, haloC1-6alkyl, cyano, nitro and C2-6alkenyl; q is 7 and R?2¿ at each occurrence is independently selected from hydrogen and C¿1-6?alkyl and at least one R?2¿ group is hydrogen and R3 is selected from substituted or unsubstituted C¿1-8?alkyl, C2-8alkenyl and C2-8alkynyl, together with processes for their manufacture and compositions containing them. Compounds of formula (I) are pharmacologically useful.
• [EN] 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS<br/>[FR] DERIVES DE 1,4-DIAZACYCLOHEPTANE EN TANT QU'AGENTS NEUROPROTECTEURS
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000078736A1

  公开（公告）日：2000-12-28

  Methods for the use of compounds of formula (I) for treatment of neurological disorders, wherein p and q are as defined in the specification and R?1, R2 and R3¿ are various substituents, also as defined in the specification, such compounds and pharmaceutical compositions containing such compounds.
• 1,4-diazacycloheptane derivatives
  申请人：Astrazenela UK Limited

  公开号：US06417183B1

  公开（公告）日：2002-07-09

  This invention provides substituted 1,2,3,4-tetrahydronaphthalene [3H]-emopamil binding site inhibitors useful in the treatment of neurological disorders. Such inhibitors are compounds of formula (I) wherein R, R1, m, R2 and n are as defined in the specification. The invention also provides pharmaceutical compositions containing such compounds, methods of using such compounds and methods of making such compounds

  这项发明提供了在治疗神经系统疾病中有用的取代1,2,3,4-四氢萘[3H]-埃莫帕米结合位点抑制剂。这些抑制剂是具有以下式(I)的化合物，其中R、R1、m、R2和n如规范中定义的。该发明还提供含有这些化合物的药物组合物、使用这些化合物的方法以及制备这些化合物的方法。