MEK抑制剂II | 623163-52-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: MEK抑制剂II
• 英文名称: MEK Inhibitor II
• 英文别名: IMDNQ 1；2-chloro-3-(N-succinimidyl)-1,4-naphthoquinone；1-(3-chloro-1,4-dioxonaphthalen-2-yl)pyrrolidine-2,5-dione
• CAS: 623163-52-0
• 化学式: C₁₄H₈ClNO₄
• 分子量: 289.675
• InChiKey: GYQSWJNGTWVFOL-UHFFFAOYSA-N

物化性质

• 沸点：
  415.6±55.0 °C(Predicted)
• 密度：
  1.58±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  71.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-3-氯-1,4-萘醌 、 丁二酰氯 生成 MEK抑制剂II
  参考文献：
  名称：

  Antitrypanosomal activities and cytotoxicity of some novel imidosubstituted 1,4-naphthoquinone derivatives

  摘要：

  研究了十一种亚氨基取代的 1,4-萘醌衍生物和硝呋噻菌胺的抗锥虫活性、细胞毒性和选择性指数。与硝呋太保（IC50 = 10.67 μM）相比，所有亚氨基萘醌类似物（IMDNQ1-IMDNQ11）对克鲁斯锥虫的作用更强，IC50 值从 0.7 μM 到 6.1 μM（p < 0.05）。对这些化合物在 Balb/C 3T3 小鼠成纤维细胞系上的细胞毒性活性的研究表明，其中四种化合物 IMDNQ1、IMDNQ2、IMDNQ3 和 IMDNQ10 的选择性指数分别为 60.25、53.97、31.83 和 275.3，使它们在抑制寄生虫生长方面的选择性显著高于硝呋太保（选择性指数 = 10.86）（p < 0.05）。

  DOI：

  10.1007/s12272-012-0103-1

文献信息

• [EN] METHOD FOR INHIBITING TRYPANSOMA CRUZI<br/>[FR] PROCÉDÉ D'INHIBITION DE TRYPANSOMA CRUZI
  申请人：UNIV HOWARD

  公开号：WO2013016661A1

  公开（公告）日：2013-01-31

  In its broadest aspect, a method for treating a mammalian patient at risk or suffering from a disease caused by a kinetoplastid parasite comprises administering to such subject an effective kinetoplasticidal amount of an imido-substituted 1,4- naphthoquinone to inhibit the kinetoplastid. In an important aspect, a method of inhibiting Trypanosoma cruzi comprises administering to a patient for prophylaxis or to a patient in need of treatment an antitrypanosomal effective amount of an imido-substituted 1 A-naphthoquinone.

  在其最广泛的方面，一种治疗受威胁或患有由原生质体寄生虫引起的疾病的哺乳动物患者的方法包括向该受试者施用有效的威力质体杀灭剂量的亚胺取代的1,4-萘醌以抑制威力体。在一个重要方面，一种抑制克氏锥虫的方法包括向需要预防或治疗的患者施用亚胺取代的1 A-萘醌的抗克氏锥虫有效量。
• Method for inhibiting Trypanosoma cruzi
  申请人：Bakare Oladapo

  公开号：US09422231B2

  公开（公告）日：2016-08-23

  Methods are provided to inhibit proliferation of Trypanosoma cruzi with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against Chagas disease.

  提供了一种通过使用含亚砜基取代的1,4-萘醌抑制克氏锥虫增殖的方法，包括新型化合物。给予含亚砜基取代的1,4-萘醌可以用于为需要治疗针对充斥病的患者提供预防或治疗。
• [EN] METHODS FOR TREATING LEISHMANIASIS<br/>[FR] MÉTHODES DE TRAITEMENT DE LA LEISHMANIOSE
  申请人：UNIV HOWARD

  公开号：WO2013074930A1

  公开（公告）日：2013-05-23

  Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leishmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.

  提供了一种方法来抑制利什曼原虫（Leishmania）的增殖，特别是对利什曼东非原虫（Leishmania donovani）使用带有亚胺取代的1,4-萘醌类化合物，包括新颖的化合物。给予亚胺取代的1,4-萘醌类化合物可以用于为需要治疗利什曼病的患者提供预防或治疗。
• METHODS FOR TREATING LEISHMANIASIS
  申请人：HOWARD UNIVERSITY

  公开号：US20140336187A1

  公开（公告）日：2014-11-13

  Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leshmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.

  提供了抑制利什曼原虫增殖的方法，特别是使用含亚胺基取代的1,4-萘醌类化合物抑制利什曼原虫的增殖，包括新型化合物。给予亚胺基取代的1,4-萘醌类化合物可以用于为需要治疗利什曼病的患者提供预防或治疗。
• Synthesis and MEK1 inhibitory activities of imido-Substituted 2-chloro-1,4-naphthoquinones
  作者：Oladapo Bakare、Curtis L. Ashendel、Hairuo Peng、Leon H. Zalkow、Edward M. Burgess

  DOI：10.1016/s0968-0896(03)00267-0

  日期：2003.7

  Mitogen activated protein kinases are of interest as research tools and as therapeutic target for certain physiological disorders. In this study, we found 2-chloro-3-(N-succinimidyl)-1,4-naphthoquinone 6 to be a selective inhibitor of MEK1 with an IC50 of 0.38 muM. An open-chain homologue, 10, showed selective cytotoxicity against renal cancer in the NCI in vitro tumor screeninQ. Structure-activity relationship study of eight compounds showed the cyclic imido-substituted chloro-1,4-naphthoquinone as more potent and selective MEK1 inhibitors than the open chain homologues. The imido-substituted chloro-1,4-naphthoquinones were synthesized in a straightforward fashion by refluxing 2-amino-3-chloro-1,4-naphthoquinone with the appropriate acid chloride or diacyl dichloride. (C) 2003 Elsevier Science Ltd. All rights reserved.