(R)-安息香甲基醚 | 82572-28-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: (R)-安息香甲基醚
• 英文名称: (R)-benzoin methyl ether
• 英文别名: benzoin methyl ether；(R)-α-methoxy-deoxybenzoin；(R)-α-Methoxy-desoxybenzoin；Ethanone, 2-methoxy-1,2-diphenyl-, (2R)-；(2R)-2-methoxy-1,2-diphenylethanone
• CAS: 82572-28-9
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: BQZJOQXSCSZQPS-OAHLLOKOSA-N

物化性质

• 沸点：
  343.4±30.0 °C(Predicted)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  安息香甲基醚 在 (S)-CCOF-9 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到
  参考文献：
  名称：

  具有可调节手性的共价有机框架，用于手性诱导的自旋选择性

  摘要：

  手性共价有机框架（CCOF）因其在各种对映选择性过程中的潜在应用而引起了广泛的兴趣。然而，利用手性诱导自旋选择性 (CISS) 实现自旋极化电流注入新技术，而无需在 CCOF 内使用永磁层，这仍然是一个尚未开发的研究领域。在这里，我们首次证明，COF 可以成为开发具有高效 CISS 的旋转过滤材料的有吸引力的平台。这有助于通过手性 1,2-二氨基环己烷和三或四（水杨醛）衍生物的亚胺缩合来设计和合成基于 Zn(salen) 的新型二维 CCOF，即 CCOFs-9–12。 CCOF-9以其独特的C 2对称“扶手椅”四取代芘构象而著称，在这些材料中表现出最明显的手性，并作为固态主体，能够对映体选择性吸附外消旋药物，其对映体过量（ee）为高达97%。用抗磁性锌 (II) 离子替代顺磁性钴 (II) 后，所得的 CCOF-9-Co 不仅保留了其高结晶度、孔隙率和出色的手性，而且还表现出增强的电导率，这是有效观察

  DOI：

  10.1021/jacs.3c13032

文献信息

• HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase
  作者：Koichi Tanaka、Toshihide Muraoka、Yasuhiro Otubo、Hiroki Takahashi、Atsushi Ohnishi

  DOI：10.1039/c5ra26520g

  日期：——

  frontier in the development of chiral stationary phases for chromatographic enantioseparation involves homochiral metal–organic frameworks (MOFs). Using enantiopure (R)-2,2′-dihydroxy-1,1′-binaphthalene-6,6′-dicarboxylic acid as a starting material, we prepared three homochiral MOFs that were further used as chiral stationary phases for high-performance liquid chromatography to separate the enantiomers

  色谱对映体分离的手性固定相开发的最后一个领域涉及同手性金属-有机骨架（MOF）。以对映体（R）-2,2'-二羟基-1,1'-双萘-6,6'-二羧酸为起始原料，制备了三种均手性MOF，进一步用作高性能液体的手性固定相色谱分离各种消旋亚砜，仲醇，β-内酰胺，安息香，黄烷酮和环氧化物的对映异构体。实验结果表明，对映体分离具有出色的性能，并强调了在手性MOF色谱柱上进行对映体分离是可行的。
• [EN] NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY BASED ON AROMATIC ALLYL AMINES<br/>[FR] NOUVELLES PHASES STATIONNAIRES CHIRALES POUR CHROMATOGRAPHIE À BASE D'AMINES D'ALLYLE AROMATIQUES
  申请人：RUDJER BOSKOVIC INST

  公开号：WO2009109792A1

  公开（公告）日：2009-09-11

  New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.

  基于手性选择剂共价结合在固体支持上的新手性固定相（CSPs）已经制备。手性选择剂是从对映异构纯芳香胺和3,5-二硝基苯甲酸中获得的，然后通过烯丙基双键连接到支持表面。这样获得的材料可以用于拆分混合物或对映富集化合物的手性分离。这些手性固定相可以作为色谱柱中的填料，通过高效液相色谱在分析和制备尺度上对萘普生类药物和其他类似的非甾体类抗炎药物（NSAID）进行对映异构体分离。
• Nanocellulose Derivative/Silica Hybrid Core-Shell Chiral Stationary Phase: Preparation and Enantioseparation Performance
  作者：Xiaoli Zhang、Litao Wang、Shuqing Dong、Xia Zhang、Qi Wu、Liang Zhao、Yanping Shi

  DOI：10.3390/molecules21050561

  日期：——

  Core-shell silica microspheres with a nanocellulose derivative in the hybrid shell were successfully prepared as a chiral stationary phase by a layer-by-layer self-assembly method. The hybrid shell assembled on the silica core was formed using a surfactant as template by the copolymerization reaction of tetraethyl orthosilicate and the nanocellulose derivative bearing triethoxysilyl and 3,5-dimethylphenyl groups. The resulting nanocellulose hybrid core-shell chiral packing materials (CPMs) were characterized and packed into columns, and their enantioseparation performance was evaluated by high performance liquid chromatography. The results showed that CPMs exhibited uniform surface morphology and core-shell structures. Various types of chiral compounds were efficiently separated under normal and reversed phase mode. Moreover, chloroform and tetrahydrofuran as mobile phase additives could obviously improve the resolution during the chiral separation processes. CPMs still have good chiral separation property when eluted with solvent systems with a high content of tetrahydrofuran and chloroform, which proved the high solvent resistance of this new material.

  通过逐层自组装方法，成功制备了在混合壳中具有纳米纤维素衍生物的核壳硅微球作为手性固定相。在硅核上组装的混合壳是通过表面活性剂作为模板，通过正硅酸四乙酯与带有三乙氧基硅烷基和3,5-二甲基苯基的纳米纤维素衍生物的共聚反应形成的。对所得的纳米纤维素混合核壳手性填料（CPMs）进行了表征并装入色谱柱，通过高效液相色谱法评估了其手性分离性能。结果表明，CPMs具有均匀的表面形貌和核壳结构。在正相和反相模式下，各种类型的手性化合物均被有效地分离。此外，作为流动相添加剂的氯仿和四氢呋喃可以明显提高手性分离过程中的分辨率。当用四氢呋喃和氯仿含量高的溶剂体系洗脱时，CPMs仍然具有良好的手性分离性能，这证明了这种新材料具有很高的耐溶剂性。
• Flash chiral chromatography using carbohydrate carbamate-coated silica
  作者：Stephen A. Matlin、Sally J. Grieb、Ana M. Belenguer

  DOI：10.1039/c39950000301

  日期：——

  Enantiomers of many chiral compounds are resolved rapidly on a preparative scale by passage through a column packed with flash chromatography silica which has been physically coated with a carbohydrate carbamate.

  许多手性化合物的对映体都可以通过闪速色谱硅胶填料柱快速制备分离。
• LIQUID CRYSTAL DISPLAY DEVICE, METHOD FOR MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE, COMPOSITION FOR FORMING POLYMER LAYER, AND COMPOSITION FOR FORMING LIQUID CRYSTAL LAYER
  申请人：Sharp Kabushiki Kaisha

  公开号：EP2418536A1

  公开（公告）日：2012-02-15

  The present invention provides a liquid crystal display device capable of reducing the probability of image sticking. The liquid crystal display device comprises a pair of substrates, and a liquid crystal layer between the substrates, wherein at least one of the substrates comprises an alignment film and a polymer layer on the alignment film, and the polymer layer is formed by polymerization of a polymerizable monomer triggered by a polymerization initiator existing at a concentration of 1 mol% or lower relative to the polymerizable monomer.

  本发明提供了一种能够降低图像粘连概率的液晶显示装置。该液晶显示装置包括一对基板和基板之间的液晶层，其中至少一个基板包括对准膜和对准膜上的聚合物层，聚合物层是由相对于可聚合单体浓度为 1 摩尔%或更低的聚合引发剂引发的可聚合单体聚合形成的。