[EN] MITOMYCIN C PRODRUG LIPOSOME FORMULATIONS AND USES THEREOF<br/>[FR] FORMULATIONS DE LIPOSOME DE PROMÉDICAMENT DE MITOMYCINE C ET LEURS UTILISATIONS
申请人:MALLINCKRODT LLC
公开号:WO2018089481A1
公开(公告)日:2018-05-17
The present invention provides MMC prodrug compounds and liposomal MMC prodrugs and compositions thereof for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid and a MMC prodrug. The present invention also provides liposomal compositions for the treatment of cancer comprising administering to a patient in need thereof a liposome, wherein the liposome comprises: a phosphatidylcholine lipid; a sterol; a PEG-lipid and a MMC prodrug or a pharmaceutically-acceptable salt thereof.
[EN] METHODS FOR THE SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS<br/>[FR] PROCÉDÉS POUR LA SYNTHÈSE D'ACIDES NUCLÉIQUES FONCTIONNALISÉS
申请人:ONTORII INC
公开号:WO2013012758A1
公开(公告)日:2013-01-24
Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H- phosphonates in a stereospecific fashion.
[EN] INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM<br/>[FR] DÉRIVÉS D'ISOQUINUCLIDÈNE RÉUNIS PAR FUSION À DE L'INDOLE ET DU BENZOFURANE ET LEURS PROCÉDÉS DE PRÉPARATION
申请人:DEMERX INC
公开号:WO2013112757A1
公开(公告)日:2013-08-01
Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (-) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms.
A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula:
in which R, R
3
and R
4
are as defined in the specification.
The present invention relates to a compound of the Formula (I)):
or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.