4-bromo-1-pyrrolidinonaphthalene | 877242-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-bromo-1-pyrrolidinonaphthalene
• 英文别名: 1-(4-bromo-1-naphthyl)pyrrolidine；1-(4-bromonaphthalen-1-yl)pyrrolidine
• CAS: 877242-78-9
• 化学式: C₁₄H₁₄BrN
• 分子量: 276.176
• InChiKey: WBZQJFZPYFVQKO-UHFFFAOYSA-N

物化性质

• 沸点：
  407.5±28.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-bromo-1-pyrrolidinonaphthalene 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  Synthesis and spectral characterization of bisnaphthylmethyl and trinaphthylmethyl cations

  摘要：

  Cationic triarylmethane dyes containing one, two or three naphthalene moieties have been prepared. Their synthesis and preliminary spectral, nonlinear optical and theoretical characterization tire reported here. The major electronic and steric hindrance effects of the 1.4-linked naphthalene have been examined by comparison of the UV-vis absorption of the 1,4-linked and 2,6-linked series. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.05.138
• 作为产物：
  描述：

  1-(Alpha-萘基)-吡咯烷 在 四溴环己二烯-1-酮 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以72%的产率得到4-bromo-1-pyrrolidinonaphthalene
  参考文献：
  名称：

  Synthesis and spectral characterization of bisnaphthylmethyl and trinaphthylmethyl cations

  摘要：

  Cationic triarylmethane dyes containing one, two or three naphthalene moieties have been prepared. Their synthesis and preliminary spectral, nonlinear optical and theoretical characterization tire reported here. The major electronic and steric hindrance effects of the 1.4-linked naphthalene have been examined by comparison of the UV-vis absorption of the 1,4-linked and 2,6-linked series. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.05.138

文献信息

• Heteroaryl compounds useful as inhibitors of E1 activating enzymes
  申请人：Claiborne F. Christopher

  公开号：US20080051404A1

  公开（公告）日：2008-02-28

  This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

  这项发明涉及抑制E1激活酶的化合物，包括这些化合物的药物组合物，以及使用这些化合物的方法。这些化合物可用于治疗疾病，特别是细胞增殖性疾病，包括癌症、炎症和神经退行性疾病；以及与感染和虚弱相关的炎症。
• HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES
  申请人：Claiborne Christopher F.

  公开号：US20120071482A1

  公开（公告）日：2012-03-22

  This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

  本发明涉及抑制E1激活酶的化合物、包含该化合物的制药组合物以及使用该化合物的方法。该化合物可用于治疗疾病，特别是细胞增殖性疾病，包括癌症、炎症和神经退行性疾病；以及与感染和消瘦相关的炎症。
• US8008307B2
  申请人：——

  公开号：US8008307B2

  公开（公告）日：2011-08-30
• US8481550B2
  申请人：——

  公开号：US8481550B2

  公开（公告）日：2013-07-09
• US8901136B2
  申请人：——

  公开号：US8901136B2

  公开（公告）日：2014-12-02