4-溴-1,8-二(溴甲基)萘 | 556108-06-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-溴-1,8-二(溴甲基)萘
• 英文名称: 4-bromo-1,8-bis(bromomethyl)naphthalene
• 英文别名: 1-bromo-4,5-bis-bromomethyl-naphthalene；1-Brom-4,5-bis-brommethyl-naphthalin；1-Bromo-4,5-bis(bromomethyl)naphthalene；4-Brom-1,8-bis-(brommethyl)-naphthalin
• CAS: 556108-06-6
• 化学式: C₁₂H₉Br₃
• 分子量: 392.915
• InChiKey: SIASFBROAMEFRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-溴-1,8-二(溴甲基)萘 反应 2.0h， 生成 <6-T>-Perinaphthan
  参考文献：
  名称：

  Opie,M.C.A. et al., Australian Journal of Chemistry, 1971, vol. 24, p. 1205 - 1209

  摘要：

  DOI：
• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 在 lithium aluminium tetrahydride 、 乙醚 、 三溴化磷 、 苯 作用下， 生成 4-溴-1,8-二(溴甲基)萘
  参考文献：
  名称：

  A New Synthesis of Acenaphthene

  摘要：

  DOI：

  10.1021/ja01107a501

文献信息

• Pharmaceutical compounds
  申请人：——

  公开号：US20040122001A1

  公开（公告）日：2004-06-24

  This invention relates to compounds of formula (I) where R 1 to R 12 , —W—V—, —X—Y—, m and n have the values defined in claim 1, their preparation and use as pharmaceuticals. 1

  这项发明涉及到式(I)的化合物，其中R1至R12，—W—V—，—X—Y—，m和n的值如权利要求1中定义的，它们的制备和用作药物。
• Isochroman compounds for treatment of cns disorders
  申请人：Agejas-Chicharro Javier

  公开号：US20050014750A1

  公开（公告）日：2005-01-20

  This invention relates to compounds of formula (I) where R1 to R12, —W—V—, —X—Y—, p and n have the values defined in claim 1, their preparation and use as pharmaceuticals.

  本发明涉及公式（I）的化合物，其中R1到R12，-W-V-，-X-Y-，p和n具有权利要求1中定义的值，它们的制备和用作药物。
• Isochroman compounds for treatment of CNS disorders
  申请人：Eli Lilly and Company

  公开号：US07335660B2

  公开（公告）日：2008-02-26

  This invention relates to compounds of formula (I) where R1 to R12, —W—V—, —X—Y—, p and n have the values defined in claim 1, their preparation and use as pharmaceuticals for the treatment of central nervous system disorders, such as depression, bipolar disorder, and anxiety.

  本发明涉及公式（I）的化合物，其中R1至R12，-W-V-，-X-Y-，p和n具有声明1中定义的值，以及它们的制备和用作药物治疗中枢神经系统疾病，如抑郁症、双相情感障碍和焦虑症。
• Synthesis and Properties of Dicarboximide Derivatives of Perylene and Azaperylene
  作者：Yukinori Nagao、Tatsurou Yoshida、Koji Arimitsu、Kozo Kozawa

  DOI：10.3987/com-09-s(s)104

  日期：——

  The N-alkyl dicarboximide derivatives of naphthylisoquinoline and binaphthalene were prepared by the hetero coupling reaction of the corresponding N-alkyl dicarboximide derivatives of stannylnaphthalene with bromodimethyisoquinoline and bromodimethylnaphthalene, respectively. The ring closing of the N-hexyl derivatives of naphthylisoquinoline and binaphthalene produced the N-hexyldicarboximide derivatives of azaperylene and perylene having the same substituents, respectively. The absorption spectra and fluorescence spectra of the azaperylene and perylene derivatives were investigated.
• Ghilardi et al., Bulletin de la Societe Chimique de France, 1953, p. 407
  作者：Ghilardi et al.

  DOI：——

  日期：——