N,N-二甲基环己烯-1-胺 | 13815-46-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N-二甲基环己烯-1-胺
• 中文别名: N,N-二甲基环己-1-烯-1-胺
• 英文名称: (cyclohex-1-enyl)dimethylamine
• 英文别名: N,N-dimethylcyclohex-1-enylamine；N,N-Dimethyl-1-cyclohexan-1-amine；N,N-dimethylcyclohexen-1-amine
• CAS: 13815-46-8
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: YQMFWWIHWNGOEK-UHFFFAOYSA-N

物化性质

• 沸点：
  160.5-162.5 °C(Press: 725 Torr)
• 密度：
  0.88±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-二甲基环己烯-1-胺 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成 2-(methylthiomethyl)cyclohexan-1-one
  参考文献：
  名称：

  A Novel Method for the α-Phenylthiomethylation of Carbonyl Compounds

  摘要：

  DOI：

  10.1055/s-1981-29424
• 作为产物：
  描述：

  2-Oxo-2-(1-dimethylamino-cyclohexyl)-P(V)-1,3,2-dioxaphosphol 生成 N,N-二甲基环己烯-1-胺
  参考文献：
  名称：

  Burgada,R.; Roussel,J., Bulletin de la Societe Chimique de France, 1970, p. 192 - 200

  摘要：

  DOI：

文献信息

• [EN] METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS FLUOROALKYLE ARYLSULFINYLÉS ET COMPOSÉS FLUORÉS APPARENTÉS
  申请人：IM & T RES INC

  公开号：WO2010022001A1

  公开（公告）日：2010-02-25

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  揭示了用于制备氟烷基芳基磺酰基化合物的新型制备方法。公开了氟化合物作为有用的氟化合物、中间体或构建块。展示了氟烷基芳基磺酰基化合物的有用应用。
• Nucleophilic addition to styryl sulphones. part II. Regio- and stereochemistry of the addition of enamines from 4-substituted cyclohexanones
  作者：F. Benedetti、S. Fabrissin、A. Risaliti

  DOI：10.1016/s0040-4020(01)91234-7

  日期：1984.1

  Formation of β- and α-adducts in the reactions of styryl sulphones with enamines from 4-alkylcyclohexanones is reexamined. Steric effects, electrostatic interactions between the nitrogen atom of the enamine and the oxygen atoms of the sulphone group, and medium effects contribute to the regioselectivity of the reaction.

  重新检查苯乙烯基砜与4-烷基环己酮的烯胺反应中β-和α-加合物的形成。立体效应，烯胺的氮原子与砜基团的氧原子之间的静电相互作用以及介质效应有助于反应的区域选择性。
• 2-Aminocycloaliphatic amide compounds
  申请人：The Upjohn Company

  公开号：US04145435A1

  公开（公告）日：1979-03-20

  Cis- and trans-N-(2-aminocycloaliphatic)-2-arylacetamide derivative compounds of the formula ##STR1## e.g., N-\x9b2-(N', \n" N'-dimethylamino)cyclohexyl!-N-methyl-2-(4-bromophenyl)acetamide and trans-N-methyl-N-\x9b2-(1-pyrrolidinyl)cyclohexyl!acetamide, \n' 2-(3,4-dichlorophenyl) and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and the preferred compounds have in addition only low to moderate apparent physical dependence liability, compared to morphine and methadone. As analgesics they would be useful also as antitussives. Processes for preparation of these compounds are also disclosed. This invention also includes compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in humans and animals, as well as methods for alleviating pain in animals and humans with these compositions.

  式子为##STR1##的顺式和反式N-(2-氨基环脂肪基)-2-芳基乙酰胺衍生物化合物，例如N-\x9b2-(N'，\n" N'-二甲基氨基)环己基!-N-甲基-2-(4-溴苯基)乙酰胺和反式N-甲基-N-\x9b2-(1-吡咯烷基)环己基!乙酰胺，2-(3,4-二氯苯基)及其药物可接受的盐，已发现具有强效镇痛活性，并且与吗啡和美沙酮相比，优选化合物仅具有低至中度的明显身体依赖性。作为镇痛剂，它们也可以作为止咳剂使用。还公开了制备这些化合物的方法。本发明还包括含有这些化合物的组合物，其以制药剂量形式对于缓解人和动物的疼痛有用，以及使用这些组合物缓解动物和人的疼痛的方法。
• Methods For Preparing Fluoroalkyl Arylsulfinyl Compounds And Fluorinated Compounds Thereto
  申请人：Umemoto Teruo

  公开号：US20110190511A1

  公开（公告）日：2011-08-04

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  本发明揭示了一种用于制备氟烷基芳基亚磺酰化合物的新型制备方法。本发明还揭示了氟化合物作为有用的氟化合物、中间体或构建块。同时，本发明还展示了氟烷基芳基亚磺酰化合物的有用应用。
• Methods for Preparing Fluoroalkyl Arylsulfinyl Compounds and Fluorinated Compounds Thereto
  申请人：Umemoto Teruo

  公开号：US20100152463A1

  公开（公告）日：2010-06-17

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or building blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  本发明公开了用于制备氟烷基芳基磺酰基化合物的新型制备方法。本发明还公开了作为有用的氟化合物、中间体或构建块的氟化合物。本发明还展示了氟烷基芳基磺酰基化合物的有用应用。