hydroxyacetaldehyde oxime | 37110-02-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hydroxyacetaldehyde oxime
• 英文别名: glycolaldoxime；2-(Hydroxyimino)ethan-1-ol；2-hydroxyiminoethanol
• CAS: 37110-02-4
• 化学式: C₂H₅NO₂
• 分子量: 75.0672
• InChiKey: XDFCKHNPTCLLTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  hydroxyacetaldehyde oxime 在 亚膦酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以3.1 g的产率得到DL-1-amino-2-hydroxyethanephosphonous acid
  参考文献：
  名称：

  New synthesis and fungicidal activity of the phosphine analogues of serine and threonine

  摘要：

  The phosphine analogues of serine and threonine were prepared by the reaction of hydroxyaldehyde oximes with H3PO2, and the acid ester of sulfuric acid and the phosphine analogue of serine was synthesised; the high fungicidal activity of these substances was found for the first time.

  DOI：

  10.1070/mc2005v015n02abeh001940
• 作为产物：
  描述：

  羟乙醛 在 盐酸羟胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 hydroxyacetaldehyde oxime
  参考文献：
  名称：

  Oxidation of 1,2-bis(hydroxylamines)

  摘要：

  DOI：

  10.1021/jo00197a032

文献信息

• The Chemistry of<i>N,N</i>-Bis(siloxy)enamines, Part 9.A General Method for the Preparation of α-Hydroxy Oximes from Aliphatic Nitro Compounds
  作者：Alexey V. Lesiv、Sema L. Ioffe、Andrey A. Tabolin、Yulija A. Khomutova、Pavel A. Belyakov、Yuriy A. Strelenko

  DOI：10.1055/s-2005-865309

  日期：——

  A new convenient procedure for the preparation of a variety of α-hydroxy oximes from available aliphatic nitro compounds via intermediate N,N-bis(siloxy)enamines is presented. The mechanism of the key step, the rearrangement of N,N-bis(siloxy)en­amines, is discussed.

  本文介绍了一种新的便捷方法，可通过中间体N,N-双(硅氧基)烯胺，从现有的脂肪族硝基化合物制备多种β-羟基肟。本文还讨论了关键步骤——N,N-双(硅氧基)烯胺的重排——的机理。
• Kahr,K.; Berther,C., Chemische Berichte, 1960, vol. 93, p. 132 - 136
  作者：Kahr,K.、Berther,C.

  DOI：——

  日期：——
• Boggs, Roger A.; Hasan, Fariza B.; Mahoney, J. Barry, Journal of the Chemical Society. Perkin transactions II, 1992, # 8, p. 1271 - 1277
  作者：Boggs, Roger A.、Hasan, Fariza B.、Mahoney, J. Barry、Mehta, Avi C.、Palumbo, Catherine M. K.、et al.

  DOI：——

  日期：——
• New synthesis and fungicidal activity of the phosphine analogues of serine and threonine
  作者：Yurii N. Zhukov、Nelli A. Vavilova、Tat’yana I. Osipova、Elena N. Khurs、Vitaly G. Dzhavakhiya、Radii M. Khomutov

  DOI：10.1070/mc2005v015n02abeh001940

  日期：2005.1

  The phosphine analogues of serine and threonine were prepared by the reaction of hydroxyaldehyde oximes with H3PO2, and the acid ester of sulfuric acid and the phosphine analogue of serine was synthesised; the high fungicidal activity of these substances was found for the first time.
• Oxidation of 1,2-bis(hydroxylamines)
  作者：Dabney White Dixon、Randy H. Weiss

  DOI：10.1021/jo00197a032

  日期：1984.11