bis-(1,2,2-trichloro-ethyl)-ether | 1195570-85-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: bis-(1,2,2-trichloro-ethyl)-ether
• 英文别名: α.β.β.α'.β'.β'-Hexachlor-diaethylaether；Bis-(1,2,2-trichlor-aethyl)-aether；1,1,2-Trichloro-2-(1,2,2-trichloroethoxy)ethane
• CAS: 1195570-85-4
• 化学式: C₄H₄Cl₆O
• 分子量: 280.793
• InChiKey: KUBIVYCXFZDWQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 五氯化磷 作用下， 生成 bis-(1,2,2-trichloro-ethyl)-ether
  参考文献：
  名称：

  Paterno; Pisali, Gazzetta Chimica Italiana, 1871, vol. 1, p. 463

  摘要：

  DOI：

文献信息

• [EN] ELECTROCHEMICALLY-CLEAVABLE LINKERS<br/>[FR] LIEURS CLIVABLES PAR VOIE ÉLECTROCHIMIQUE
  申请人：MICROSOFT TECHNOLOGY LICENSING LLC

  公开号：WO2021158412A1

  公开（公告）日：2021-08-12

  This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

  这份披露提供了具有低于使用的溶剂的氧化还原电位的可电化学裂解连接物。在某些应用中，溶剂可能是水或水溶液缓冲液。这些连接物可用于将核苷酸连接到结合基团。连接物包括可裂解基团，可能是甲氧基苯甲醇、酯、丙炔硫醚或三氯乙基醚中的一种。通过产生低于溶剂的氧化还原电位的电极电位，可以在溶剂中裂解这些连接物。在某些实施中，可以使用电极阵列来产生局部电极电位，从而选择性地裂解与激活电极结合的连接物。这些连接物的用途包括在酶催化寡核苷酸合成中将阻断基团附着到核苷酸上。
• Novel CD40 : CD154 binding interruptor compounds and use thereof to treat immunological complications
  申请人：——

  公开号：US20040067982A1

  公开（公告）日：2004-04-08

  The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.

  本发明涉及新型CD40：CD154结合中断化合物以及使用这些化合物和包含它们的药物组合物，用于治疗与受试者中不适当的CD154激活相关的疾病。具体而言，本发明提供通过筛选小分子库以识别能够特异性结合CD154并中断CD40：CD154相互作用的化合物。
• Novel CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications
  申请人：Zheng Zhongli

  公开号：US20070249682A1

  公开（公告）日：2007-10-25

  The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.

  本发明涉及新型CD40：CD154结合中断化合物的使用以及包含这些化合物的制药组合物，用于治疗与主体中不适当的CD154激活有关的疾病。具体而言，本发明提供了通过筛选小分子库以鉴定能够特异性结合CD154并中断CD40：CD154相互作用的化合物。
• LINKER STRUCTURES WITH MINIMAL SCAR FOR ENZYMATIC SYNTHESIS
  申请人：MICROSOFT TECHNOLOGY LICENSING, LLC

  公开号：US20220204544A1

  公开（公告）日：2022-06-30

  This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

  本公开提供具有比使用的溶剂的氧化还原电位更低的解离电位的电化学可裂解连接剂。在某些应用中，溶剂可以是水或水溶液缓冲液。连接剂可用于将核苷酸连接到结合基团上。连接剂包括可裂解基团，可为甲氧基苯甲醇、酯、丙炔硫醚或三氯乙基醚之一。连接剂可通过产生比溶剂的氧化还原电位低的电极电位在溶剂中裂解。在某些实施例中，可使用电极阵列来产生局部电极电位，选择性地裂解与激活电极结合的连接剂。连接剂的用途包括在酶催化寡核苷酸合成中将阻断基团附加到核苷酸上。
• Method for identifying a member of a mass-coded combinatorial library
  申请人：Neogenesis, Inc.

  公开号：EP1728776A2

  公开（公告）日：2006-12-06

  The present invention provides a method for the use of a mass-coded combinatorial library for identifying a ligand to a first biomolecule but is not a ligand to a second biomolecule, where the mass-coded combinatorial library comprises a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer from 2 to 6. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 250 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties.

  本发明提供了一种使用质量编码组合库鉴定第一种生物分子的配体但不是第二种生物分子的配体的方法，其中质量编码组合库包括一组具有通式 X(Y)n 的化合物，其中 X 是支架，每个 Y 独立地是外周分子，n 是 2 到 6 的整数。该方法包括从外周分子前体集中选择外周分子前体子集。该子集包括足够数量的外围分子前体，至少存在约 250 种不同的组合，这些组合来自该子集中的外围分子前体。选择外围分子前体子集的目的是，在由子集衍生的 n 个外围分子的所有可能组合中，至少有约 90% 的分子质量总和与 n 个外围分子的所有其他组合的分子质量总和不同。