1,4-bis-(2-chloro-propionyl)-piperazine | 6328-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-bis-(2-chloro-propionyl)-piperazine
• 英文别名: N,N'-Di-(2-chlor-propionyl)-piperazin；1,4-Bis-(2-Chlorpropionyl)piperazin；N,N-Bis(2-chloropropionyl)piperazine；2-chloro-1-[4-(2-chloropropanoyl)piperazin-1-yl]propan-1-one
• CAS: 6328-56-9
• 化学式: C₁₀H₁₆Cl₂N₂O₂
• mdl: MFCD19374314
• 分子量: 267.155
• InChiKey: XMFIZKIUOBYBRT-UHFFFAOYSA-N

物化性质

• 沸点：
  428.3±45.0 °C(Predicted)
• 密度：
  1.286±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4,5,6-四氢-2-嘧啶硫醇 、 1,4-bis-(2-chloro-propionyl)-piperazine 以 乙醇 为溶剂， 生成 2-methyl-2H,5H,-6,7-dihydrothiazolo<3,2-a>pyrimidin-3(2H)-one
  参考文献：
  名称：

  环状硫脲与氯酰基哌嗪的反应

  摘要：

  DOI：

  10.1007/bf00508682
• 作为产物：
  描述：

  哌嗪 、 2-氯丙酰氯 生成 1,4-bis-(2-chloro-propionyl)-piperazine
  参考文献：
  名称：

  环状硫脲与氯酰基哌嗪的反应

  摘要：

  DOI：

  10.1007/bf00508682

文献信息

• BISARYL COMPOUND AND MEDICAMENT FOR CANCER TREATMENT COMPRISING THE SAME
  申请人：——

  公开号：US20030018070A1

  公开（公告）日：2003-01-23

  A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 represents a nonmetal bridging group; Ar 1 and Ar 2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.

  一种治疗癌症的药物，包括以下通用公式（I）所代表的化合物或其生理上可接受的盐：Ar1—S—R1—S—Ar2其中R1代表非金属桥接基团；Ar1和Ar2独立地代表从芳基组中选择的一种组，该芳基组在其环上具有一个至三个羟基，可选地被一价基团取代，并且该芳基组在其环上可能有一个至三个除羟基外的取代基；以及在其环上具有一个至三个羟基的杂环芳基组，可选地被一价基团取代，并且该杂环芳基组在其环上可能有一个至三个除羟基外的取代基。
• Bisaryl compound and medicament for cancer treatment comprising the same
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：US20030199560A1

  公开（公告）日：2003-10-23

  A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 represents a nonmetal bridging group; Ar 1 and Ar 2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.

  一种用于治疗癌症的药物，包含下述一般式（I）所表示的化合物或其生理上可接受的盐：Ar1—S—R1—S—Ar2其中，R1表示非金属桥接基团；Ar1和Ar2独立表示从以下组成的群体中选择的一种群体：在其环上具有一到三个羟基的芳基基团，该芳基基团可以选择性地被单价基团取代，并且该芳基基团的环上可能有一到三个除羟基外的取代基；以及在其环上具有一到三个羟基的杂环基团，该杂环基团可以选择性地被单价基团取代，并且该杂环基团的环上可能有一到三个除羟基外的取代基。
• BISARYL COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0990439A1

  公开（公告）日：2000-04-05

  A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof:         Ar1-S-R1-S-Ar2 wherein R1 represents a nonmetal bridging group; Ar1 and Ar2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.

  一种治疗癌症的药物，由以下通式 (I) 所代表的化合物或其生理上可接受的盐组成： Ar1-S-R1-S-Ar2 其中 R1 代表非金属桥基；Ar1 和 Ar2 独立地代表选自以下组别的一个基团：芳基，其环上有一至三个羟基，任选被一价基团取代，且所述芳基环上可有一至三个羟基以外的取代基；杂芳基，其环上有一至三个羟基，任选被一价基团取代，且所述杂芳基环上可有一至三个羟基以外的取代基。
• Verwendung von N,N'-Bis-(halogenacyl)-diaza-cycloalkanen zum Schutz von Kulturpflanzen vor Schädigungen durch Herbizide
  申请人：BAYER AG

  公开号：EP0023305B1

  公开（公告）日：1983-03-02
• US4392882A
  申请人：——

  公开号：US4392882A

  公开（公告）日：1983-07-12