4-[4-(4-oxo-butyl)-piperidine-1-sulfonyl]-tetrahydro-pyran-4-carboxylic acid tert-butyl ester | 622389-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[4-(4-oxo-butyl)-piperidine-1-sulfonyl]-tetrahydro-pyran-4-carboxylic acid tert-butyl ester
• 英文别名: Tert-butyl 4-[4-(4-oxobutyl)piperidin-1-yl]sulfonyloxane-4-carboxylate
• CAS: 622389-98-4
• 化学式: C₁₉H₃₃NO₆S
• 分子量: 403.54
• InChiKey: GCWHZDSPTFHGDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-[4-(4-oxo-butyl)-piperidine-1-sulfonyl]-tetrahydro-pyran-4-carboxylic acid tert-butyl ester 、 (3,3,4,4,4-pentafluorobutyl)triphenylphosphonium iodide 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以59.9%的产率得到4-[4-(7,7,8,8,8-pentafluoro-oct-4-enyl)-piperidine-1-sulfonyl]-tetrahydro-pyran-4-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

  摘要：

  这项发明通常涉及蛋白酶抑制剂（也称为“蛋白酶”），更具体地涉及对哌啶基和哌嗪基磺酰甲基羟肟酸的抑制作用，其中包括抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）活性和/或聚集素酶活性。这些羟肟酸通常在结构上对应于以下公式： （其中A 1 ，A 2 ，Y，E 1 ，E 2 ，E 3 和R x 如本说明书中所定义），并进一步包括这些化合物的盐。这项发明还涉及这些羟肟酸的组合物，合成这些羟肟酸的中间体，制备这些羟肟酸的方法，以及治疗与MMP活性和/或聚集素酶活性相关的病症（特别是病理性病症）的方法。

  公开号：

  US20050009838A1
• 作为产物：
  描述：

  4-[4-(4-hydroxy-butyl)-piperidine-1-sulfonyl]-tetrahydro-pyran-4-carboxylic acid tert-butyl ester 在 草酰氯 、 二甲基亚砜 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.33h， 以81.1%的产率得到4-[4-(4-oxo-butyl)-piperidine-1-sulfonyl]-tetrahydro-pyran-4-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

  摘要：

  这项发明通常涉及蛋白酶抑制剂（也称为“蛋白酶”），更具体地涉及对哌啶基和哌嗪基磺酰甲基羟肟酸的抑制作用，其中包括抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）活性和/或聚集素酶活性。这些羟肟酸通常在结构上对应于以下公式： （其中A 1 ，A 2 ，Y，E 1 ，E 2 ，E 3 和R x 如本说明书中所定义），并进一步包括这些化合物的盐。这项发明还涉及这些羟肟酸的组合物，合成这些羟肟酸的中间体，制备这些羟肟酸的方法，以及治疗与MMP活性和/或聚集素酶活性相关的病症（特别是病理性病症）的方法。

  公开号：

  US20050009838A1

文献信息

• Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
  申请人：McDonald J. Joseph

  公开号：US20050209278A1

  公开（公告）日：2005-09-22

  This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A 1 , A 2 , Y, E 1 , E 2 , E 3 , and R x are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

  这项发明通常涉及蛋白酶抑制剂（也称为“蛋白酶”），更具体地涉及哌啶基和哌嗪基磺酰甲基羟肟酸，该类化合物在结构上抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）活性和/或聚集素酶活性。这类羟肟酸通常对应以下结构式： （其中A1、A2、Y、E1、E2、E3和Rx如本说明书中所定义），还包括这类化合物的盐。这项发明还涉及这类羟肟酸的组合物、合成这类羟肟酸的中间体、制备这类羟肟酸的方法，以及治疗与MMP活性和/或聚集素酶活性相关的疾病（特别是病理性疾病）的方法。
• Flame-retardant polyester fiber and artificial hair comprising the same
  申请人：Masuda Toshiyuki

  公开号：US20050245647A1

  公开（公告）日：2005-11-03

  A flame resistant polyester fiber, while maintaining physical properties, such as heat resistance, tensile strength and elongation, etc. of usual polyester fibers, having excellent flame resistance and excellent setting property, and furthermore having controlled gloss of fiber is provided. A composition obtained by melt kneading of a polyester (A) comprising polyalkylene terephthalates, and one or more kinds of copolymerized polyesters having polyalkylene terephthalate as a principal component; a polymer alloy (B) consisting of polyalkylene terephthalates and polyarylates; phosphorus based flame resistant agents (C); and phosphite based compounds (D), and organic fine particles (E) and/or inorganic fine particles (F) are mixed thereto to obtain a composition. The obtained composition is melt spun to obtain a flame resistant polyester fiber in which the above-mentioned problems are solved, and to obtain artificial hair using the fiber.

  本发明提供了一种阻燃聚酯纤维，它在保持普通聚酯纤维的耐热性、拉伸强度和伸长率等物理性能的同时，还具有优异的阻燃性和优良的定型性能，而且还能控制纤维的光泽度。将由聚对苯二甲酸对苯二甲酯和一种或多种以聚对苯二甲酸对苯二甲酯为主要成分的共聚聚酯组成的聚酯（A）、由聚对苯二甲酸对苯二甲酯和聚芳酸酯组成的聚合物合金（B）、磷基阻燃剂（C）和亚磷酸基化合物（D）以及有机微粒（E）和/或无机微粒（F）熔融捏合，得到一种组合物。将得到的组合物进行熔融纺丝，即可得到阻燃聚酯纤维，解决了上述问题，并可使用该纤维获得人造毛发。
• PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACID AND THEIR USE AS PROTEASE INHIBITORS
  申请人：Pharmacia Corporation

  公开号：EP1501827A2

  公开（公告）日：2005-02-02
• US7119203B2
  申请人：——

  公开号：US7119203B2

  公开（公告）日：2006-10-10
• [EN] PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS<br/>[FR] ACIDES PIPERIDINYLSULFONYLMETHYLHYDROXAMIQUES ET PIPERAZINYLSULFONYLMETHYLHYDROXAMIQUES ET LEUR UTILISATION COMME INHIBITEURS DE PROTEASE
  申请人：PHARMACIA CORP

  公开号：WO2003091247A2

  公开（公告）日：2003-11-06

  This invention is directed generally to proteinase (also known as 'protease') inhibitors, and more particularly, to piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids that inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I), (Wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.