2-chloro-1-(4-hydroxy-phenyl)-ethanol | 4973-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-chloro-1-(4-hydroxy-phenyl)-ethanol
• 英文别名: 4-Oxy-1-(β-chlor-α-oxy-aethyl)-benzol；2-Chlor-1-(4-hydroxy-phenyl)-aethanol；Chlormethyl-(4-oxy-phenyl)-carbinol；2-Chlor-1-(4-hydroxy-phenyl)-ethanol-1；1-(4-Hydroxyphenyl)-2-chloroethanol；4-(2-chloro-1-hydroxyethyl)phenol
• CAS: 4973-17-5
• 化学式: C₈H₉ClO₂
• 分子量: 172.611
• InChiKey: LIRPGLPOHOMCQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯-4'-羟基苯乙酮 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 2-chloro-1-(4-hydroxy-phenyl)-ethanol
  参考文献：
  名称：

  Tandem Concurrent Processes: One-Pot Single-Catalyst Biohydrogen Transfer for the Simultaneous Preparation of Enantiopure Secondary Alcohols

  摘要：

  A novel one-pot tandem biohydrogen transfer process to concurrently obtain two enantiopure sec-alcohols is presented; thus, using a suitable single enzyme and a catalytic amount of cofactor, several interesting building blocks could be easily achieved in an enantiocomplementary fashion, minimizing dramatically the quantity of reagents usually employed in the "coupled-substrate" approach.

  DOI：

  10.1021/jo802350f

文献信息

• Process for producing optically active halohydrin compound
  申请人：——

  公开号：US20040082820A1

  公开（公告）日：2004-04-29

  A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &agr;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

  一种制备光学活性卤代醇化合物的方法，其特征在于在存在具有取代或未取代环戊二烯基基团和光学活性二胺化合物的9族过渡金属化合物的情况下进行α-卤代酮化合物的不对称氢转移还原。最好在碱存在下进行不对称氢转移还原。
• DE364039
  申请人：——

  公开号：——

  公开（公告）日：——
• Hinsberg, Chemisches Zentralblatt, 1923, vol. 94, # II, p. 912
  作者：Hinsberg

  DOI：——

  日期：——
• Tandem Concurrent Processes: One-Pot Single-Catalyst Biohydrogen Transfer for the Simultaneous Preparation of Enantiopure Secondary Alcohols
  作者：Fabricio R. Bisogno、Iván Lavandera、Wolfgang Kroutil、Vicente Gotor

  DOI：10.1021/jo802350f

  日期：2009.2.20

  A novel one-pot tandem biohydrogen transfer process to concurrently obtain two enantiopure sec-alcohols is presented; thus, using a suitable single enzyme and a catalytic amount of cofactor, several interesting building blocks could be easily achieved in an enantiocomplementary fashion, minimizing dramatically the quantity of reagents usually employed in the "coupled-substrate" approach.