(E)-1-cyclohexyl-N-methylmethanimine | 19885-73-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-1-cyclohexyl-N-methylmethanimine
• 英文别名: E-1-cyclohexyl-N-methylmethanimine；syn-Cyclohexancarbaldehyd-N-methyl-imin
• CAS: 19885-73-5
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: VGUGMPKRNPKTDI-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  9.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  N,N-二乙基-2-甲基苯甲酰胺 、 (E)-1-cyclohexyl-N-methylmethanimine 在 lithium diisopropyl amide 作用下， 生成 3-Cyclohexyl-2-methyl-3,4-dihydro-2H-isoquinolin-1-one
  参考文献：
  名称：

  Synthesis of 3-substituted and 3,4-disubstituted 3,4-dihydro-1(2H)-isoquinolones by condensation of lithiated N,N-diethyl-o-toluamide with imines

  摘要：

  DOI：

  10.1021/jo00233a013
• 作为产物：
  描述：

  甲胺 、 环己烷基甲醛 在 氢氧化钾 作用下， 生成 (E)-1-cyclohexyl-N-methylmethanimine
  参考文献：
  名称：

  核磁共振结构研究—十八：N-烷基亚胺的构象和构型异构

  摘要：

  通过对它们的60-Mc NMR光谱进行分析，将构象和构型分配给了几种N-Me亚胺和N-烷基乙二胺。所有醛亚胺仅以syn构型存在。N-Me Aldimines的邻位和远距离（跨4和5和键）自旋-自旋耦合常数的解释得出以下结论：I和II是这些化合物的最小能量构象。I⇌II的ΔH°值介于通常为负数的醛和为正数的肟及其O-甲基醚之间。N-烷基乙缩醛亚胺的长距离自旋-自旋偶合常数的解释（跨越4和5个键）得出以下结论：III比IV稳定得多。

  DOI：

  10.1016/s0040-4020(01)92599-2

文献信息

• [EN] SUBSTITUTED PYRIMIDINES<br/>[FR] PYRIMIDINES SUBSTITUÉES
  申请人：MERCK SHARP & DOHME

  公开号：WO2013043624A1

  公开（公告）日：2013-03-28

  The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

  本发明涉及作为HIF脯氨酰羟化酶抑制剂用于治疗贫血和类似病症的取代嘧啶。
• Preparation of homoallylic amines <i>via</i> a three-component coupling process
  作者：Xiaoxu Ou、Ricardo Labes、Claudio Battilocchio、Steven V. Ley

  DOI：10.1039/c8ob01831f

  日期：——

  A three-component synthesis of homoallylic amines is described. The allylboronic species were generated in situ by homologation of vinyl boroxines with trimethylsilyldiazomethane, then followed by trapping of the allylboron intermediate with imines. Twenty-seven compounds were successfully prepared in moderate to high yields. Imines bearing various functional groups were tolerated, including aliphatic

  描述了均烯丙基胺的三组分合成。通过用三甲基甲硅烷基重氮甲烷同价的乙烯基硼氧烷同系物原位产生烯丙基硼物种，然后用亚胺捕获烯丙基硼中间体。以中等至高收率成功制备了27种化合物。容许带有各种官能团的亚胺，包括脂族，芳族和杂芳族取代基。还报道了一些均胺的进一步加工以形成阿西地汀。
• Three-component carboarylation of unactivated imines with arynes and carbon nucleophiles
  作者：Jing-Kun Xu、Sheng-Jun Li、Hai-Yang Wang、Wen-Cong Xu、Shi-Kai Tian

  DOI：10.1039/c6cc09311f

  日期：——

  With 2-(trimethylsilyl)aryl triflates as aryne precursors, an unprecedented three-component carboarylation reaction of unactivated imines with arynes and carbon nucleophiles has been developed to access a variety of functionalized tertiary amines...

  以2-（三甲基甲硅烷基）芳基三氟甲磺酸酯为芳烃前体，已开发出前所未有的未活化亚胺与芳烃和碳亲核试剂的三组分碳芳基化反应，以获取各种官能化叔胺。
• METHOD FOR PRODUCING AROMATIC COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20150322101A1

  公开（公告）日：2015-11-12

  A method is provided for producing an aromatic compound, including a step of mixing a compound represented by formula (A) and a compound represented by formula (B): in the presence of at least one phosphine compound selected from the group consisting of a phosphine represented by formula (C) and a phosphonium salt represented by formula (F): a base, a palladium compound, and an aprotic organic solvent.

  提供一种生产芳香化合物的方法，包括以下步骤：在至少一种磷化物化合物的存在下，将由化学式(A)表示的化合物与由化学式(B)表示的化合物混合；所述磷化物化合物选择自由化学式(C)表示的磷化物和由化学式(F)表示的磷酸盐；还包括碱、钯化合物和无水有机溶剂。
• Polymer compound and polymer light emitting device
  申请人：Yamamoto Takakazu

  公开号：US20120200808A1

  公开（公告）日：2012-08-09

  To provide a polymer compound which is useful as a light emitting material or charge transport material having a boron atom. A polymer compound comprising a structure represented by a formula (1) as described below: wherein R 1 , R 2 , and R 3 each independently represents a hydrogen atom or a substituent.

  提供一种聚合物化合物，可用作具有硼原子的发光材料或电荷传输材料。包括以下公式（1）所表示的结构的聚合物化合物：其中R1、R2和R3分别独立表示氢原子或取代基。