1,2-bis(β-aminoethyl)diaziridine | 135309-25-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,2-bis(β-aminoethyl)diaziridine
• 英文别名: 1,2-bis(2-aminoethyl)diaziridine；2,2'-(Diaziridine-1,2-diyl)di(ethan-1-amine)；2-[2-(2-aminoethyl)diaziridin-1-yl]ethanamine
• CAS: 135309-25-0
• 化学式: C₅H₁₄N₄
• 分子量: 130.193
• InChiKey: HGSSTRUVBAGLGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  zinc(II) nitrate 、 1,2-bis(β-aminoethyl)diaziridine 以 异丙醇 为溶剂， 以92%的产率得到bis[1,2-bis(2-aminoethyl)diaziridine]zinc(II) dinitrate
  参考文献：
  名称：

  N-(2-氨基乙基)二氮丙啶与过渡金属盐配合物的合成与结构

  摘要：

  合成了一系列N-(2-氨基乙基)二氮丙啶与过渡金属盐(Zn2+、Cd2+、Ni2+、Co2+、Mn2+或Fe2+)的配合物。它们的结构是通过红外光谱和核磁共振光谱确定的。双[1,2-双(2-氨基乙基)二氮丙啶]镉(II)二过氯化物的结构通过X射线衍射分析证实。

  DOI：

  10.1007/bf02494928
• 作为产物：
  描述：

  1,2-bis(2-acetamidoethyl)-1,2-diazacyclopropane 在 氢氧化钾 作用下， 以37%的产率得到1,2-bis(β-aminoethyl)diaziridine
  参考文献：
  名称：

  The role of pH in the synthesis of diaziridines

  摘要：

  The greatest yield in the synthesis of diaziridines from carbonyl compounds, amines, and aminating reagents in water is achieved at a specific pH, which shifts to less alkaline values with increasing -I effect of the substituents in the carbonyl compound and with decreasing pK(BH+) value of the amine. The role of pH is related to the conditions for the generation of an immonium from the intermediate alpha-aminocarbinol. The nuclear Overhauser effect was used to determine the orientation of the substituents in several diastereomers of the didikyldiaziridines obtained.

  DOI：

  10.1007/bf00959732

文献信息

• Sinditskii, V. P.; Dutov, M. D.; Fogel'zang, A. E., Russian Journal of Inorganic Chemistry, 1991, vol. 36, p. 535 - 538
  作者：Sinditskii, V. P.、Dutov, M. D.、Fogel'zang, A. E.、Kuznetsov, V. V.

  DOI：——

  日期：——
• The role of pH in the synthesis of diaziridines
  作者：V. V. Kuznetsov、N. N. Makhova、Yu. A. Strelenko、L. I. Khmel'nitskii

  DOI：10.1007/bf00959732

  日期：1991.12

  The greatest yield in the synthesis of diaziridines from carbonyl compounds, amines, and aminating reagents in water is achieved at a specific pH, which shifts to less alkaline values with increasing -I effect of the substituents in the carbonyl compound and with decreasing pK(BH+) value of the amine. The role of pH is related to the conditions for the generation of an immonium from the intermediate alpha-aminocarbinol. The nuclear Overhauser effect was used to determine the orientation of the substituents in several diastereomers of the didikyldiaziridines obtained.
• Synthesis and structures of complexes ofN-(2-aminoethyl)diaziridines with transition metal salts
  作者：A. V. Shevtsov、V. Yu. Petukhova、S. A. Kutepov、V. V. Kuznetsov、N. N. Makhova、N. E. Kuz'mina、G. G. Aleksandrov

  DOI：10.1007/bf02494928

  日期：2000.11

  A series of complexes ofN-(2-aminoethyl)diaziridines with transition metal salts (Zn2+, Cd2+, Ni2+, Co2+, Mn2+, or Fe2+) were synthesized. Their structures were established by IR and NMR spectroscopy. The structure of bis[1,2-bis(2-aminoethyl)diaziridine]cadmium(II) diperehlorate was confirmed by X-ray diffraction analysis.

  合成了一系列N-(2-氨基乙基)二氮丙啶与过渡金属盐(Zn2+、Cd2+、Ni2+、Co2+、Mn2+或Fe2+)的配合物。它们的结构是通过红外光谱和核磁共振光谱确定的。双[1,2-双(2-氨基乙基)二氮丙啶]镉(II)二过氯化物的结构通过X射线衍射分析证实。