3-(1-(2-methylbenzyl)piperidin-4-yl)-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(1-(2-methylbenzyl)piperidin-4-yl)-1H-indole
• 英文别名: 3-[1-[(2-methylphenyl)methyl]piperidin-4-yl]-1H-indole
• 化学式: C₂₁H₂₄N₂
• 分子量: 304.435
• InChiKey: GIHAWICNPOSBKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-(1-苄基-1,2,3,6-四氢吡啶-4-基)-1H-吲哚 在 palladium 10% on activated carbon 、 氢气 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 乙酸乙酯 、 1,2-二氯乙烷 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 4.0h， 生成 3-(1-(2-methylbenzyl)piperidin-4-yl)-1H-indole
  参考文献：
  名称：

  Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

  摘要：

  A series of 3-piperidin-4-yl-1H-indoles with building block diversity was synthesized based on a hit derived from an HTS whole-cell screen against Plasmodium falciparum. Thirty-eight compounds were obtained following a three-step synthetic approach and evaluated for anti-parasitic activity. The SAR shows that 3-piperidin-4-yl-1H-indole is intolerant to most N-piperidinyl modifications. Nevertheless, we were able to identify a new compound (10d) with lead-like properties (MW = 305; cLogP = 2.42), showing antimalarial activity against drug-resistant and sensitive strains (EC50 values similar to 3 mu M), selectivity for malaria parasite and no cross-resistance with chloroquine, thus representing a potential new chemotype for further optimization towards novel and affordable antimalarial drugs. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.07.047

文献信息

• Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype
  作者：Sofia A. Santos、Amanda K. Lukens、Lis Coelho、Fátima Nogueira、Dyann F. Wirth、Ralph Mazitschek、Rui Moreira、Alexandra Paulo

  DOI：10.1016/j.ejmech.2015.07.047

  日期：2015.9

  A series of 3-piperidin-4-yl-1H-indoles with building block diversity was synthesized based on a hit derived from an HTS whole-cell screen against Plasmodium falciparum. Thirty-eight compounds were obtained following a three-step synthetic approach and evaluated for anti-parasitic activity. The SAR shows that 3-piperidin-4-yl-1H-indole is intolerant to most N-piperidinyl modifications. Nevertheless, we were able to identify a new compound (10d) with lead-like properties (MW = 305; cLogP = 2.42), showing antimalarial activity against drug-resistant and sensitive strains (EC50 values similar to 3 mu M), selectivity for malaria parasite and no cross-resistance with chloroquine, thus representing a potential new chemotype for further optimization towards novel and affordable antimalarial drugs. (C) 2015 Elsevier Masson SAS. All rights reserved.