1,1-bis(β-chloroethyl)hydrazine hydrochloride | 13495-35-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-bis(β-chloroethyl)hydrazine hydrochloride
• 英文别名: N,N-Bis(2-chloroethyl)hydrazinhydrochlorid；N,N-Di(2-chlorethyl)hydrazin-hydrochlorid；N,N-Di(2-Chlorethyl)hydrazinhydrochlorid；N,N-bis-(2-chloro-ethyl)-hydrazine; hydrochloride；N,N-Bis-(2-chlor-aethyl)-hydrazin; Hydrochlorid；N,N-Bis-(2-chloraethyl)-hydrazin-hydrochlorid；Hydrazine, 1,1-bis(2-chloroethyl)-, hydrochloride；1,1-bis(2-chloroethyl)hydrazine;hydrochloride
• CAS: 13495-35-7
• 化学式: C₄H₁₀Cl₂N₂*ClH
• 分子量: 193.504
• InChiKey: CGXNDDNPLNNCNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.06
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-酮丁酸 、 1,1-bis(β-chloroethyl)hydrazine hydrochloride 生成 2--buttersaeure
  参考文献：
  名称：

  Schulze,W.; Letsch,G., Journal fur praktische Chemie (Leipzig 1954), 1963, vol. 21, p. 272 - 276

  摘要：

  DOI：

文献信息

• Studies on Carcinostatic Substances. XLI. Preparation of Azide Derivatives of 1, 1-Bis (2-chloroethyl) hydrazine
  作者：Yoshio Sakurai、Michiko Aoshima

  DOI：10.1248/cpb.10.979

  日期：——

  Derivetives of 1, 1-bis (2-chloroethyl) hydrazine, especially of amino acid hydrazine type, were prepared for the purpose of testing their latent antitumor activity.

  1,1-双(2-氯乙基)肼的衍生物，尤其是氨基酸肼类型的衍生物，被制备出来以测试它们的潜在抗肿瘤活性。
• Reaction of 1,1-disubstituted hydrazines with bromine in the presence of aryl- and heteroarylnitroso compounds in acid media: A general method for the synthesis of 1-aryl(heteroaryl)-3,3-disubstituted triazene 1-oxides
  作者：S. G. Zlotin、O. V. Prokshits、N. F. Karpenko、Yu. A. Strelenko、O. A. Luk'yanov

  DOI：10.1007/bf00864338

  日期：1992.8

  We have worked out a method for the synthesis of 1,3,3-trisubstituted triazene 1-oxides based upon reaction of 1,1-disubstituted hydrazines with bromine in the presence of aryl- and heteroarylnitroso compounds in acid media. Obtained are a broad range of triazene 1-oxides, among which hitherto unknown compounds of the series of pyrazole and 3,3-dialkyltriazene 1-oxides that contain functional groups at the alkyl part of the molecule. We propose a reaction scheme which includes in situ formation of diazenium cations and reaction of them with nitroso compounds that are present in the system. By means of PMR, C-13, and N-14 NMR spectroscopy, and mass spectroscopy, it has been shown that in all the prepared compounds the oxidated nitrogen atom is at the N1 position of the triazene N-oxide group.
• Schulze,W.; Letsch,G., Journal fur praktische Chemie (Leipzig 1954), 1962, vol. 16, p. 182 - 187
  作者：Schulze,W.、Letsch,G.

  DOI：——

  日期：——
• PREUSSMANN, Arzneimittel-Forschung/Drug Research, 1962, vol. 12, p. 260 - 265
  作者：PREUSSMANN

  DOI：——

  日期：——
• Schulze,W.; Letsch,G., Journal fur praktische Chemie (Leipzig 1954), 1961, vol. 14, p. 11 - 16
  作者：Schulze,W.、Letsch,G.

  DOI：——

  日期：——