1,1-二氯-2-甲基丙烷 | 598-76-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 1,1-二氯-2-甲基丙烷
• 英文名称: 1,1-dichloro-2-methyl-propane
• 英文别名: 1,1-Dichlor-2-methyl-propan；Isobutylidendichlorid；α.α-Dichlor-isobutan；Isobutylidenchlorid；1.1-Dichlor-2-methylpropane；1,1-Dichlor-2-methylpropan；1,1-Dichloroisobutane；1,1-dichloro-2-methylpropane
• CAS: 598-76-5
• 化学式: C₄H₈Cl₂
• 分子量: 127.014
• InChiKey: JVHKSSIDGAUKGK-UHFFFAOYSA-N

物化性质

• 熔点：
  -70.34°C (estimate)
• 沸点：
  105°C
• 密度：
  1.1000
• 保留指数：
  727;727

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,1-二氯-2-甲基丙烷 在 mercury(II) fluoride 作用下， 生成 1-chloro-1-fluoro-2-methyl-propane
  参考文献：
  名称：

  Henne; Plueddeman, Journal of the American Chemical Society, 1943, vol. 65, p. 1272

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁烷 生成 1,1-二氯-2-甲基丙烷
  参考文献：
  名称：

  Chlorination process and product thereof

  摘要：

  公开号：

  US02004072A1

文献信息

• Novel pyridine derivative and pyrimidine derivative
  申请人：Matsushima Tomohiro

  公开号：US20050277652A1

  公开（公告）日：2005-12-15

  A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R 1 represents C 1-6 alkyl or the like; R 2 and R 3 represent hydrogen; R 4 , R 5 , R 6 , and R 7 may be the same or different and each represents hydrogen, halogen, C 1-6 alkyl or the like; R 8 represents hydrogen or the like; R 9 represents C 1-6 alkyl or the like; V 1 represents oxygen or the like; V 2 represents oxygen or sulfur; W represents —NH— or the like; X represents —CH═, nitrogen or the like; and Y represents oxygen or the like.]

  以下化合物的分子式，其盐或前述水合物具有出色的肝细胞生长因子受体（HGFR）抑制活性，并表现出抗肿瘤活性、抑制血管生成活性和抑制癌转移活性。 [R 1 代表C 1-6 烷基或类似物；R 2 和R 3 代表氢；R 4 ，R 5 ，R 6 和R 7 可以相同也可以不同，每个代表氢、卤素、C 1-6 烷基或类似物；R 8 代表氢或类似物；R 9 代表C 1-6 烷基或类似物；V 1 代表氧或类似物；V 2 代表氧或硫；W代表—NH—或类似物；X代表—CH═、氮或类似物；Y代表氧或类似物。]
• RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES
  申请人：Takabe Fumiaki

  公开号：US20110287937A1

  公开（公告）日：2011-11-24

  Provided are 2-pyridone derivatives which have excellent herbicidal activity and exhibit high safety to useful crops and so on; salts thereof; and herbicides containing same. In more detail, 2-pyridone derivatives represented by general formula [I] or agrochemically acceptable salts thereof, and herbicides containing these compounds are provided. In general formula [I], X 1 is an oxygen atom or a sulfur atom; X 2 , X 3 , and X 4 are to each CH or N(O) m ; m is an integer of 0 or 1; R 1 is a hydrogen atom, a C 1-12 alkyl group, or the like; R 2 is a halogen atom, a cyano group, or the like; n is an integer of 0 to 4; R 3 is a hydroxyl group, a halogen atom, or the like; A 1 is C(R 11 R 12 ); A 2 is C(R 13 R 14 ) or C═O; A 3 is C(R 15 R 16 ); and R 11 , R 12 , R 13 , R 14 , R 15 , and R 16 are each independently a hydrogen atom or a C 1-6 alkyl group.

  提供了具有优异除草活性并对有用作物等表现出高安全性的2-吡啶酮衍生物；其盐；以及含有这些化合物的除草剂。更详细地说，提供了通式[I]所表示的2-吡啶酮衍生物或其农药可接受的盐，以及含有这些化合物的除草剂。在通式[I]中，X1是氧原子或硫原子；X2、X3和X4分别为CH或N(O)m；m是0或1的整数；R1是氢原子，C1-12烷基或类似物；R2是卤素原子，氰基或类似物；n是0到4的整数；R3是羟基，卤素原子或类似物；A1是C(R11R12)；A2是C(R13R14)或C═O；A3是C(R15R16)；R11、R12、R13、R14、R15和R16分别独立地是氢原子或C1-6烷基基团。
• [EN] FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE<br/>[FR] COMPOSITION FONGICIDE CONTENANT UN DÉRIVÉ D'AMIDE D'ACIDE
  申请人：ISHIHARA SANGYO KAISHA

  公开号：WO2006016708A1

  公开（公告）日：2006-02-16

  Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing an acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzyl which may be substituted, naphthyl which may be substituted, heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or the like; B is heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or naphthyl which may be substituted; each of R1 and R2 which are independent of each other, is alkyl, or the like; R3 is hydrogen, or the like; each of W1 and W2 which are independent of each other, is oxygen or sulfur.

  传统的许多杀真菌组合物存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，控制植物病害的效果往往不足，因此需要一种能够克服这些问题的杀真菌组合物。本发明提供了一种含有式(I)的酸酰胺衍生物或其盐的杀真菌组合物作为活性成分：其中A是苯基，可能被取代，苄基，可能被取代，萘基，可能被取代，杂环环，可能被取代，融合的杂环环，可能被取代，或类似物；B是可能被取代的杂环环，融合的可能被取代的杂环环，或可能被取代的萘基；R1和R2各自独立的，是烷基，或类似物；R3是氢，或类似物；W1和W2各自独立的，是氧或硫。
• [EN] 4-HYDROXY-3-(HETEROARYL)PYRIDINE-2-ONE APJ AGONISTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS<br/>[FR] AGONISTES D'APJ 4-HYDROXY-3-(HÉTÉROARYL)PYRIDINE-2-ONE À UTILISER DANS LE TRAITEMENT DE TROUBLES CARDIO-VASCULAIRES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016196771A1

  公开（公告）日：2016-12-08

  The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

  本发明提供了公式（I）中所有变量如规范所定义的化合物，以及包含任何此类新化合物的组合物。这些化合物是APJ激动剂，可用作药物。
• [EN] AMMONOLYSIS PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR DPP IV INHIBITORS<br/>[FR] PROCEDE D'AMMONOLYSE DESTINE A LA PREPARATION D'INTERMEDIAIRES POUR DES INHIBITEURS IV DPP
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2006020664A2

  公开（公告）日：2006-02-23

  A process is provided for preparing the intermediate A in accordance with the following reaction sequence. The intermediate A is used in preparing DPP IV inhibitors which are useful in treating diabetes.

  提供了一种制备中间体A的方法，符合以下反应序列。中间体A用于制备DPP IV抑制剂，这些抑制剂对治疗糖尿病有用。